Hedgehog signaling in basal cell carcinoma
Open accessAbstract
Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with deep invasion, destruction of adjacent structures, recurrence and, on very rare occasions, regional and distant metastases. Mutations that occur in BCC in hedgehog (Hh) pathway genes primarily involve the genes encoding patched homolog (PTCH) and smoothened homolog (SMO). Several animal models have demonstrated the functional relevance of genetic alterations in the Hh pathway during tumorigenesis. Recently, targeted therapy has become available both commercially and in the context of human clinical trials. Interestingly, Hh pathway inhibitors not only suppress BCC progression but also promote acquired immune responses. Since immune responses are crucial for long-term tumor control, new clinical trials, such as those involving a combination of Hh inhibitors with immune modifiers, are needed to supplement standard methods of tumor control.
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Tumor cells may evade immune recognition by downregulating tumor antigens or MHC class I.
“Tumor cells may evade immune recognition directly by downregulating features that make them vulnerable such as tumor antigens or MHC class I (4–6).”
From Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations (2018) · cites this paper as [5]
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- Authors
- Otsuka, A., Levesque, M. P., Dummer, R., & Kabashima, K.
- Affiliations
- Kyoto University (JP)
- University Hospital Zurich (CH)
- Corresponding author
- Otsuka, Atsushi
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 78
- Issue
- 2
- Pages
- 95-100
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2048774760
- Cited by
- 72
- References
- 46
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- basal cell carcinoma, Hedgehog signaling, PTCH mutations, SMO mutations, Hedgehog pathway inhibitors, targeted therapy, tumor immunology, immune response, tumor recurrence, metastasis, skin cancer
- MeSH terms
- Patched Receptors, Patched-1 Receptor, Smoothened Receptor, Anilides, Animals, Antineoplastic Agents, Basal Cell Carcinoma, Humans, Pyridines, Receptors, Cell Surface, Skin Neoplasms, Signal Transduction, Receptors, G-Protein-Coupled, Hedgehog Proteins, Adaptive Immunity, Molecular Targeted Therapy
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