Linking air pollution to atopic dermatitis
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Numerous genetic-based factors and environmental stimuli interact in the same individual, leading to triggering or worsening of AD.
“Numerous genetic-based factors and environmental stimuli interact in the same individual, leading to the triggering or worsening of AD.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [6]
PAHs activate AHR by binding to AHR in cytoplasm, then induce translocation of AHR to cell nuclei to regulate cellular gene expression.
“At the molecular level, PAHs have been shown to activate aryl hydrocarbon receptors (AHRs) while binding to the AHR in cytoplasm, then induce translocation of AHR to the cell nuclei to regulate cellular gene expression (11, 12).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [11]
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“5, induce nuclear translocation of AHR in stimulated cells and modulate gene expression (11, 12).”
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Lee, J. S., Ahn, H. K., Cho, S. I., Mun, J., Kim, K. H., & Lee, D. H. (2026) · PLoS ONE · doi:10.1371/journal.pone.0352199
- Authors
- Kabashima, K., Otsuka, A., & Nomura, T.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Kabashima, Kenji
- Venue
- Nature Immunology
- Published
- 2016-12-16
- Volume
- 18
- Issue
- 1
- Pages
- 5-6
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2565313357
- Cited by
- 47
- References
- 12
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 6
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15H05790)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- atopic dermatitis, air pollution, aryl hydrocarbon receptor, skin innervation, itch-scratch cycle, air pollution exposure
- MeSH terms
- Air Pollution, Dermatitis, Atopic, Humans
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