Bogyo, Matthew

Activity-Based Profiling of Proteases

Sanman, L. E., & Bogyo, M. (2014) · Annual Review of Biochemistry

Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

Cited by 330

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Aillaud, C., Bosc, C., Peris, L., Bosson, A., Heemeryck, P., Van Dijk, J., Le Friec, J., Boulan, B., Vossier, F., Sanman, L. E., et al. (2017) · Science

Microtubule and mitosis dynamicsNeurogenesis and neuroplasticity mechanisms

Cited by 293

Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation

Orlowski, G. M., Colbert, J. D., Sharma, S., Bogyo, M., Robertson, S. A., & Rock, K. L. (2015) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 268

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

Ward, M. E., Chen, R., Huang, H.-Y., Ludwig, C., Telpoukhovskaia, M., Taubes, A., Boudin, H., Minami, S. S., Reichert, M., Albrecht, P., et al. (2017) · Science Translational Medicine

Lysosomal Storage Disorders ResearchAmyotrophic Lateral Sclerosis Research

Cited by 193

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

Edgington, L. E., Verdoes, M., & Bogyo, M. (2011) · Current Opinion in Chemical Biology

Protease and Inhibitor MechanismsMolecular Sensors and Ion Detection

Cited by 169

Selective activation of PFKL suppresses the phagocytic oxidative burst

Amara, N., Cooper, M. P., Voronkova, M. A., Webb, B. A., Lynch, E. M., Kollman, J. M., Ma, T., Yu, K., Lai, Z., Sangaraju, D., et al. (2021) · Cell

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 158

AND-gate contrast agents for enhanced fluorescence-guided surgery

Widen, J. C., Tholen, M., Yim, J. J., Antaris, A., Casey, K. M., Rogalla, S., Klaassen, A., Sorger, J., & Bogyo, M. (2020) · Nature Biomedical Engineering

Nanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection

Cited by 142

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

Cattaruzza, F., Lyo, V., Jones, E., Pham, D., Hawkins, J., Kirkwood, K., Valdez–Morales, E., Ibeakanma, C., Vanner, S. J., Bogyo, M., et al. (2011) · Gastroenterology

Pain Mechanisms and TreatmentsProtease and Inhibitor Mechanisms

Cited by 103

An in vivo multiplexed small-molecule screening platform

Grüner, B. M., Schulze, C. J., Yang, D., Ogasawara, D., Dix, M. M., Rogers, Z. N., Chuang, C.-H., McFarland, C. D., Chiou, S.-H., Brown, J. M., et al. (2016) · Nature Methods

Cancer Cells and MetastasisSingle-cell and spatial transcriptomics

Cited by 62

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

Keller, L., Nguyen, T., Liu, L., Lakemeyer, M., Gelsinger, D., Chanin, R., Ngo, N., Lum, K., Faucher, F., Ipock, P., et al. (2022) · Nature Chemical Biology

Bacterial Genetics and BiotechnologyGut microbiota and health

Cited by 25

Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron

Keller, L. J., Nguyen, T. H., Liu, L. J., Hurysz, B. M., Lakemeyer, M., Guerra, M., Gelsinger, D. J., Chanin, R., Ngo, N., Lum, K. M., et al. (2023) · Nature Chemical Biology

Bacterial Genetics and BiotechnologyGut microbiota and health

Cited by 24

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Telpoukhovskaia, M. A., Liu, K., Sayed, F. A., Etchegaray, J. I., Xie, M., Zhan, L., Li, Y., Zhou, Y., Le, D., Bahr, B. A., et al. (2020) · Scientific Reports

Neuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Cited by 23

Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

Bennett, J. M., Narwal, S. K., Kabeche, S., Abegg, D., Thathy, V., Hackett, F., Yeo, T., Li, V. L., Muir, R., Faucher, F., et al. (2024) · Cell Chemical Biology

Malaria Research and ControlOrganophosphorus compounds synthesis

Cited by 3

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

Bennett, J. M., Narwal, S. K., Kabeche, S., Abegg, D., Hackett, F., Yeo, T., Li, V. L., Muir, R. K., Faucher, F. F., Lovell, S., et al. (2024) · Cell chemical biology

Malaria Research and ControlOrganophosphorus compounds synthesis

Cited by 3