Gavin, Anne-Claude

Drug target identification using side-effect similarity

Campillos, M., Kuhn, M., Gavin, A.-C., Jensen, L. J., & Bork, P. (2008) · Science

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 1,248

Proteome organization in a genome-reduced bacterium

Kühner, S., van Noort, V., Betts, M. J., Leo-Macias, A., Batisse, C., Rode, M., Yamada, T., Maier, T., Bader, S., Beltran-Alvarez, P., et al. (2009) · Science

Bacterial Genetics and BiotechnologyMicrobial infections and disease research

Cited by 471

Transcriptome complexity in a genome-reduced bacterium

Güell, M., van Noort, V., Yus, E., Chen, W.-H., Leigh-Bell, J., Michalodimitrakis, K., Yamada, T., Arumugam, M., Doerks, T., Kühner, S., et al. (2009) · Science

Bacterial Genetics and BiotechnologyMicrobial infections and disease research

Cited by 418

Structure-Based Assembly of Protein Complexes in Yeast

Aloy, P., Böttcher, B., Ceulemans, H., Leutwein, C., Mellwig, C., Fischer, S., Gavin, A.-C., Bork, P., Superti-Furga, G., Serrano, L., et al. (2004) · Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 383

Impact of genome reduction on bacterial metabolism and its regulation

Yus, E., Maier, T., Michalodimitrakis, K., van Noort, V., Yamada, T., Chen, W.-H., Wodke, J. A. H., Güell, M., Martínez, S., Bourgeois, R., et al. (2009) · Science

Bacterial Genetics and BiotechnologyMicrobial Metabolic Engineering and Bioproduction

Cited by 327

Quantification of mRNA and protein and integration with protein turnover in a bacterium

Maier, T., Schmidt, A., Güell, M., Kühner, S., Gavin, A., Aebersold, R., & Serrano, L. (2011) · Molecular Systems Biology

Bacterial Genetics and BiotechnologyGene Regulatory Network Analysis

Cited by 297

Modules, networks and systems medicine for understanding disease and aiding diagnosis

Gustafsson, M., Nestor, C. E., Zhang, H., Barabási, A.-L., Baranzini, S., Brunak, S., Chung, K. F., Federoff, H. J., Gavin, A.-C., Meehan, R. R., et al. (2014) · Genome Medicine

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 194

A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1

Gavin, A.-C., & Nebreda, A. R. (1999) · Current Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 158

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 105

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Hennrich, M. L., Romanov, N., Horn, P., Jaeger, S., Eckstein, V., Steeples, V., Ye, F., Ding, X., Poisa-Beiro, L., Lai, M. C., et al. (2018) · Nature Communications

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 101

Isoform- and cell-state-specific lipidation of ApoE in astrocytes

Lindner, K., Beckenbauer, K., van Ek, L. C., Titeca, K., de Leeuw, S. M., Awwad, K., Hanke, F., Korepanova, A. V., Rybin, V., van der Kam, E. L., et al. (2022) · Cell Reports

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 84

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

Liu, Y., Bunney, T. D., Khosa, S., Macé, K., Beckenbauer, K., Askwith, T., Maslen, S., Stubbs, C., de Oliveira, T. M., Sader, K., et al. (2020) · EBioMedicine

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 42

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells

Poisa-Beiro, L., Thoma, J., Landry, J., Sauer, S., Yamamoto, A., Eckstein, V., Romanov, N., Raffel, S., Hoffmann, G. F., Bork, P., et al. (2020) · Scientific Reports

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 23

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

de Leeuw, S. M., Kirschner, A. W. T., Lindner, K., Rust, R., Budny, V., Wolski, W. E., Gavin, A.-C., Nitsch, R. M., & Tackenberg, C. (2022) · Stem Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 14

Isoform- and cell-state-specific APOE homeostasis and function

Lindner, K., & Gavin, A.-C. (2024) · Neural Regeneration Research

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 13

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

Roy, S., Roy, S., Mahata, B., Pramanik, J., Hennrich, M. L., Gavin, A.-C., & Teichmann, S. A. (2023) · Frontiers in Immunology

Click Chemistry and ApplicationsProtein Interaction Studies and Fluorescence Analysis

Cited by 5

CLICK- chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

Roy, S., Roy, S., Mahata, B., Pramanik, J., Hennrich, M. L., Gavin, A.-C., & Teichmann, S. A. (2023) · Frontiers in Immunology

Click Chemistry and ApplicationsProtein Interaction Studies and Fluorescence Analysis

Cited by 5