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Cited by 13Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Isoform- and cell-state-specific APOE homeostasis and function

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Lindner, Karina, Gavin, Anne-Claude·2024·Neural Regeneration Research
DOI 10.4103/nrr.nrr-d-23-01470PMC PMC11090418
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Abstract

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer’s disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer’s disease.

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  • APOE plays a central role in neuronal lipid homeostasis, membrane remodeling, and neurite dynamics in an isoform dependent manner, with protective variants supporting greater structural resilience and synaptic integrity.

    “APOE plays a central role in neuronal lipid homeostasis, membrane remodeling, and neurite dynamics in an isoform dependent manner, with protective variants supporting greater structural resilience and synaptic integrity (Huang and Mahley, 2014; Lindner et al., 2024).”

    From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Lindner et al., 2024

    The Introduction describes APOE as central to brain lipid homeostasis and neuronal membrane architecture. The Lipidation and Secretion section links APOE to neurite growth and reports that APOE4 negatively affects neurite growth and neural plasticity. Although the Introduction identifies variants protective against Alzheimer’s disease, the paper does not say those variants specifically support greater structural resilience or synaptic integrity. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Lindner, K., & Gavin, A.-C.
Affiliations
University of Geneva (CH)
Corresponding author
Gavin, Anne-Claude
ORCID
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2024-01-31
Volume
19
Issue
11
Pages
2456-2466
ISSN
  • 1673-5374 (ISSN-L)
  • 1876-7958
DOI
10.4103/nrr.nrr-d-23-01470
PMC
PMC11090418
OpenAlex
W4391436869
Cited by
13
References
22
Citations by year
2026: 7 · 2025: 3 · 2024: 3
FWCI
3.70
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Neural Regeneration Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by-nc-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Université de Genève
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
apolipoprotein E, APOE isoforms, APOE polymorphism, Alzheimer's disease, lipid transport

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