Sheppard, Dean

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Stockis, J., Liénart, S., Colau, D., Collignon, A., Nishimura, S. L., Sheppard, D., Coulie, P. G., & Lucas, S. (2017) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyTGF-β signaling in diseases

Cited by 111

Absence of Integrin αvβ3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation

Su, G., Atakilit, A., Li, J. T., Wu, N., Bhattacharya, M., Zhu, J., Shieh, J. E., Li, E., Chen, R., Sun, S., et al. (2012) · American Journal of Respiratory and Critical Care Medicine

Cell Adhesion Molecules ResearchSepsis Diagnosis and Treatment

Cited by 92

Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.

Boylan, A. M., Sanan, D. A., Sheppard, D., & Broaddus, V. C. (1995) · Journal of Clinical Investigation

Occupational and environmental lung diseasesCell Adhesion Molecules Research

Cited by 86

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

Dodagatta-Marri, E., Ma, H.-Y., Liang, B., Li, J., Meyer, D. S., Sun, K.-H., Ren, X., Zivak, B., Rosenblum, M. D., Headley, M. B., et al. (2020) · Cell Reports

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 70

Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction

Arnold, T. D., Lizama, C. O., Cautivo, K. M., Santander, N., Lin, L., Qiu, H., Huang, E. J., Liu, C., Mukouyama, Y.-S., Reichardt, L. F., et al. (2019) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 67

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Fenton, T. M., Kelly, A., Shuttleworth, E. E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S. L., Sheppard, D., Levison, S., et al. (2017) · Mucosal Immunology

TGF-β signaling in diseasesInflammatory Bowel Disease

Cited by 64

Effective Treatment of Mouse Sepsis With an Inhibitory Antibody Targeting Integrin αvβ5*

Su, G., Atakilit, A., Li, J. T., Wu, N., Luong, J., Chen, R., Bhattacharya, M., & Sheppard, D. (2013) · Critical Care Medicine

Sepsis Diagnosis and TreatmentCell Adhesion Molecules Research

Cited by 36