Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8
Open accessAbstract
Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflammatory bowel disease (IBD). A vital cytokine in regulating intestinal T cells is transforming growth factor-β (TGFβ), which is secreted by cells as a latent complex that requires activation to function. However, how TGFβ activation is regulated in the human intestine, and how such pathways are altered in IBD is completely unknown. Here we show that a key activator of TGFβ, integrin αvβ8, is highly expressed on human intestinal dendritic cells (DCs), specifically on the CD1c + but not the CD141 + intestinal DC subset. Expression was significantly upregulated on intestinal DC from IBD patients, indicating that inflammatory signals may upregulate expression of this key TGFβ-activating molecule. Indeed, we found that the Toll-like receptor 4 ligand lipopolysaccharide upregulates integrin αvβ8 expression and TGFβ activation by human DC. We also show that DC expression of integrin αvβ8 enhanced induction of FOXP3 in CD4 + T cells, suggesting functional importance of integrin αvβ8 expression by human DC. These results show that microbial signals enhance the TGFβ-activating ability of human DC via regulation of integrin αvβ8 expression, and that intestinal inflammation may drive this pathway in patients with IBD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Memory CD8+ T cells provide long-term immunity against key tumor epitopes.
“Additionally, memory CD8+ T cells provide long-term immunity against key tumor epitopes189.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [189]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Intestinal homeostasis and its breakdown in inflammatory bowel disease
Maloy, K., & Powrie, F. (2011) · Nature · doi:10.1038/nature10208 · Cited by 1,865 · see citing works
Self-citationInduction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242 · see citing works
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., et al. (2016) · Nature · doi:10.1038/nature17655 · Cited by 1,072 · see citing works
Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J., Dunbar, P. R., Wadley, R. B., Jeet, V., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092140 · Cited by 1,019 · see citing works
Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions
Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N., & Crowe, S. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00001 · Cited by 993 · see citing works
Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G., & Levings, M. K. (2007) · International Immunology · doi:10.1093/intimm/dxm014 · Cited by 872 · see citing works
TGF-β Activation and Function in Immunity
Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works
Self-citationBachem, A., Güttler, S., Hartung, E., Ebstein, F., Schaefer, M., Tannert, A., Salama, A., Movassaghi, K., Opitz, C., Mages, H. W., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100348 · Cited by 821 · see citing works
Gavin, M. A., Torgerson, T. R., Houston, E., DeRoos, P. C., Ho, W., Stray‐Pedersen, A., Ocheltree, E., Greenberg, P. D., Ochs, H. D., & Rudensky, A. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509484103 · Cited by 779 · see citing works
Abe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., & Rifkin, D. B. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1042 · Cited by 757 · see citing works
Edelson, B. T., Wumesh, K. C., Juang, R., Kohyama, M., Benoît, L. A., Klekotka, P. A., Moon, C., Albring, J. C., Ise, W., Michael, D. G., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091627 · Cited by 710 · see citing works
Poulin, L. F., Salio, M., Griessinger, E., Anjos‐Afonso, F., Craciun, L., Chen, J., Keller, A. M., Joffre, O. P., Zelenay, S., Nye, E. L., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092618 · Cited by 667 · see citing works
Peripheral and Intestinal Regulatory CD4+CD25high T Cells in Inflammatory Bowel Disease
Maul, J., Loddenkemper, C., Mundt, P., Berg, E. G., Giese, T., Stallmach, A., Zeitz, M., & Duchmann, R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.043 · Cited by 651 · see citing works
Crozat, K., Guiton, R., Contreras, V., Feuillet, V., Dutertre, C., Ventre, E., Manh, T. V., Baranek, T., Storset, A. K., Marvel, J., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100223 · Cited by 628 · see citing works
IRF8 Mutations and Human Dendritic-Cell Immunodeficiency
Hambleton, S., Salem, S., Bustamante, J. C., Bigley, V., Boisson‐Dupuis, S., Azevedo, J., Fortin, A., Haniffa, M. A., Ceron‐Gutierrez, L., Bacon, C. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100066 · Cited by 604 · see citing works
Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease
Monteleone, G., Kumberová, A., Croft, N. M., McKenzie, C. A., Steer, H. W., & MacDonald, T. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12821 · Cited by 602 · see citing works
Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature · doi:10.1038/nature06110 · Cited by 503 · see citing works
Self-citationMongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Monteleone, G., Neurath, M. F., Ardizzone, S., Sabatino, A. D., Fantini, M. C., Castiglione, F., Scribano, M. L., Armuzzi, A., Caprioli, F., Sturniolo, G. C., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1407250 · Cited by 401 · see citing works
Babyatsky, M. W., Rossiter, G., & Podolsky, D. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613031 · Cited by 389 · see citing works
Transient regulatory T-cells: A state attained by all activated human T-cells
Pillai, V., Ortega, S. B., Wang, C. K., & Karandikar, N. J. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.10.014 · Cited by 339 · see citing works
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches
Reboldi, A., Arnon, T. I., Rodda, L. B., Atakilit, A., Sheppard, D., & Cyster, J. G. (2016) · Science · doi:10.1126/science.aaf4822 · Cited by 339 · see citing works
Self-citationWatchmaker, P. B., Lahl, K., Lee, M., Baumjohann, D., Morton, J. M., Kim, S. J., Zeng, R., Dent, A. L., Ansel, K. M., Diamond, B., et al. (2013) · Nature Immunology · doi:10.1038/ni.2768 · Cited by 267 · see citing works
Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins
Lacy‐Hulbert, A., Smith, A. M., Tissire, H., Barry, M., Crowley, D. G., Bronson, R. T., Roes, J., Savill, J., & Hynes, R. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707421104 · Cited by 225 · see citing works
Aluwihare, P., Mu, Z., Zhao, Z., Yu, D., Weinreb, P. H., Horan, G. S. B., Violette, S. M., & Munger, J. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.035246 · Cited by 224 · see citing works
Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
Saruta, M., Yu, Q., Fleshner, P. R., Mantel, P., Schmidt‐Weber, C. B., Banham, A. H., & Papadakis, K. A. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.003 · Cited by 203 · see citing works
Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression
Fantini, M. C., Rizzo, A., Fina, D., Caruso, R., Sarra, M., Stolfi, C., Becker, C., MacDonald, T. T., Pallone, F., Neurath, M. F., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.12.053 · Cited by 179 · see citing works
Worthington, J. J., Czajkowska, B. I., Melton, A. C., & Travis, M. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.057 · Cited by 172 · see citing works
Self-citationDietary influences on intestinal immunity
Veldhoen, M., & Brucklacher-Waldert, V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3299 · Cited by 164 · see citing works
Intestinal dendritic cells in the regulation of mucosal immunity
Bekiaris, V., Persson, E. K., & Agace, W. W. (2014) · Immunological Reviews · doi:10.1111/imr.12194 · Cited by 158 · see citing works
Luda, K. M., Joeris, T., Persson, E. K., Rivollier, A., Demiri, M., Sitnik, K., Pool, L., Holm, J. B., Melo-González, F., Richter, L., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.008 · Cited by 151 · see citing works
Self-citationYoshida, Y., Yoshimi, R., Yoshii, H., Kim, D., Dey, A., Xiong, H., Munasinghe, J., Yazawa, I., O'Donovan, M. J., Maximova, O. A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.022 · Cited by 145 · see citing works
Païdassi, H., Acharya, M., Zhang, A., Mukhopadhyay, S., Kwon, M., Chow, C., Stuart, L. M., Savill, J., & Lacy‐Hulbert, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.076 · Cited by 125 · see citing works
Melton, A. C., Bailey-Bucktrout, S. L., Travis, M. A., Fife, B. T., Bluestone, J. A., & Sheppard, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43786 · Cited by 123 · see citing works
Self-citationGuardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells
Gross, M., Salame, T., & Jung, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00254 · Cited by 109 · see citing works
Fiocchi, C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13863 · Cited by 91 · see citing works
Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease
Minagawa, S., Lou, J., Seed, R. I., Cormier, A., Wu, S., Cheng, Y., Murray, L., Tsui, P., Connor, J., Herbst, R., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008074 · Cited by 90 · see citing works
Self-citationSanders, T. J., McCarthy, N. E., Giles, E. M., Davidson, K. L. M., Haltalli, M. L. R., Hazell, S., Lindsay, J. O., & Stagg, A. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.057 · Cited by 85 · see citing works
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells
McMurchy, A. N., Gillies, J., Gizzi, M. C., Riba, M., Garcia-Manteiga, J. M., Cittaro, D., Lazarevic, D., Di Nunzio, S., Piras, I. S., Bulfone, A., et al. (2013) · Blood · doi:10.1182/blood-2012-05-431023 · Cited by 77 · see citing works
Worthington, J. J., Klementowicz, J. E., Rahman, S., Czajkowska, B. I., Smedley, C., Waldmann, H., Sparwasser, T. D., Grencis, R. K., & Travis, M. A. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003675 · Cited by 39 · see citing works
Self-citationMarkovics, J. A., Araya, J., Cambier, S., Jablons, D. M., Hill, A. C., Wolters, P. J., & Nishimura, S. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.113977 · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
Dendritic Cell Regulation of T Helper Cells
Yin, X., Chen, S., & Eisenbarth, S. C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-025146 · Cited by 447 · see citing works
Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease
Murphy-Ullrich, J. E., & Suto, M. J. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.12.009 · Cited by 337 · see citing works
Ihara, S., Hirata, Y., & Koike, K. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1350-1 · Cited by 300 · see citing works
Integrins as Therapeutic Targets: Successes and Cancers
Raab-Westphal, S., Marshall, J. F., & Goodman, S. L. (2017) · Cancers · doi:10.3390/cancers9090110 · Cited by 242 · see citing works
Bernardo, D., Marín, A. C., Fernández‐Tomé, S., Montalban‐Arques, A., Carrasco, A., Tristán, E., Moreno, L. O., Mora‐Gutiérrez, I., Díaz-Guerra, A., Caminero-Fernández, R., et al. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0030-7 · Cited by 154 · see citing works
Regulation of Innate and Adaptive Immunity by TGFβ
Kelly, A., Houston, S. A., Sherwood, E., Casulli, J., & Travis, M. A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.01.001 · Cited by 142 · see citing works
Self-citationAbraham, C., Abreu, M. T., & Turner, J. R. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.12.288 · Cited by 127 · see citing works
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation
Kelly, A., Gunaltay, S., McEntee, C. P., Shuttleworth, E. E., Smedley, C., Houston, S. A., Fenton, T. M., Levison, S., Mann, E. R., & Travis, M. A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171491 · Cited by 124 · see citing works
Self-citationControlling Immunity and Inflammation through Integrin-Dependent Regulation of TGF-β
Nolte, M. A., & Margadant, C. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.10.002 · Cited by 121 · see citing works
Takasaka, N., Seed, R. I., Cormier, A., Bondesson, A. J., Lou, J., Elattma, A., Ito, S., Yanagisawa, H., Hashimoto, M., Ma, R., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122591 · Cited by 119 · see citing works
Self-citationBlocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8
Stockis, J., Liénart, S., Colau, D., Collignon, A., Nishimura, S. L., Sheppard, D., Coulie, P. G., & Lucas, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710680114 · Cited by 111 · see citing works
Self-citationILC1 drive intestinal epithelial and matrix remodelling
Jowett, G. M., Norman, M. D. A., Yu, T. T. L., Arévalo, P. R., Hoogland, D., Lust, S. T., Read, E., Hamrud, E., Walters, N. J., Niazi, U. H. K., et al. (2020) · Nature Materials · doi:10.1038/s41563-020-0783-8 · Cited by 111 · see citing works
The role of TGF-beta signaling in dendritic cell tolerance
Esebanmen, G. E., & Langridge, W. H. R. (2017) · Immunologic Research · doi:10.1007/s12026-017-8944-9 · Cited by 95 · see citing works
Kang, J., Lee, J. H., Cha, H., An, J., Kwon, J., Lee, S., Kim, S., Baykan, M. Y., Kim, S. Y., An, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48310-4 · Cited by 86 · see citing works
Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses
Durand, M., Walter, T., Pirnay, T., Naessens, T., Gueguen, P., Goudot, C., Lameiras, S., Chang, Q., Talaei, N., Ornatsky, O., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181994 · Cited by 84 · see citing works
Role of food proteins and bioactive peptides in inflammatory bowel disease
Fernández‐Tomé, S., Hernández‐Ledesma, B., Chaparro, M., Indiano‐Romacho, P., Bernardo, D., & Gisbert, J. P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.017 · Cited by 82 · see citing works
Tamayo, E., Álvarez, P., & Merino, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123928 · Cited by 80 · see citing works
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells
Bourque, J., & Hawiger, D. (2018) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2018026790 · Cited by 78 · see citing works
Human dendritic cell subsets: An updated view of their ontogeny and functional specialization
Segura, É. (2022) · European Journal of Immunology · doi:10.1002/eji.202149632 · Cited by 77 · see citing works
Antigen-Presenting Cells in Food Tolerance and Allergy
Liu, E. G., Yin, X., Swaminathan, A., & Eisenbarth, S. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616020 · Cited by 76 · see citing works
Rao, A., Strauss, O., Kokkinou, E., Bruchard, M., Tripathi, K. P., Schlums, H., Carrasco, A., Mazzurana, L., Kónya, V., Villablanca, E. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15695-x · Cited by 74 · see citing works
Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease
Caër, C., & Wick, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00410 · Cited by 73 · see citing works
αvβ8 integrin adhesion and signaling pathways in development, physiology and disease
McCarty, J. H. (2020) · Journal of Cell Science · doi:10.1242/jcs.239434 · Cited by 66 · see citing works
Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD
Liu, H., Dasgupta, S., Fu, Y., Bailey, B., Roy, C., Lightcap, E. S., & Faustin, B. (2019) · BMC Immunology · doi:10.1186/s12865-019-0322-z · Cited by 64 · see citing works
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation
McEntee, C. P., Finlay, C. M., & Lavelle, E. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01266 · Cited by 62 · see citing works
Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
Stuelten, C. H., & Zhang, Y. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.764727 · Cited by 57 · see citing works
The renaissance of oral tolerance: merging tradition and new insights
Cerovic, V., Pabst, O., & Mowat, A. M. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01077-7 · Cited by 50 · see citing works
Functions of Dendritic Cells and Its Association with Intestinal Diseases
Yang, Z., Wang, B., Wang, T., Wang, F., Guo, Y., Hua, R., Shang, H., Lü, X., & Xu, J. (2021) · Cells · doi:10.3390/cells10030583 · Cited by 47 · see citing works
Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Bernardo, D., Chaparro, M., & Gisbert, J. P. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700931 · Cited by 46 · see citing works
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide
Reichart, F., Maltsev, O. V., Kapp, T. G., Räder, A. F. B., Weinmüller, M., Marelli, U. K., Notni, J., Wurzer, A. J., Beck, R., Wester, H., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01588 · Cited by 43 · see citing works
Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice
Cohen, T. S., Takahashi, V., Bonnell, J. C., Tovchigrechko, A., Chaerkady, R., Yu, W., Jones-Nelson, O., Lee, Y., Raja, R. G., Hess, S. Y., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126938 · Cited by 41 · see citing works
Self-citationMcEntee, C. P., Gunaltay, S., & Travis, M. A. (2020) · Immunology · doi:10.1111/imm.13162 · Cited by 39 · see citing works
Self-citationRegulation of mononuclear phagocyte function by the microbiota at mucosal sites
Scott, N. A., & Mann, E. R. (2019) · Immunology · doi:10.1111/imm.13155 · Cited by 35 · see citing works
Ihara, S., Hirata, Y., Hikiba, Y., Yamashita, A., Tsuboi, M., Hata, M., Konishi, M., Suzuki, N., Sakitani, K., Kinoshita, H., et al. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy088 · Cited by 34 · see citing works
Thielen, N. G. M., van Caam, A., van Beuningen, H. M., Vitters, E. L., van den Bosch, M. H. J., Koenders, M. I., van de Loo, F. A. J., Davidson, E. N. B., & van der Kraan, P. M. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.08.004 · Cited by 24 · see citing works
van Caam, A., Aarts, J., van Ee, T., Vitters, E. L., Koenders, M. I., van de Loo, F., van Lent, P., van den Hoogen, F. H. J., Thurlings, R. M., Vonk, M. C., et al. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-2130-5 · Cited by 22 · see citing works
Pásztói, M., Pezoldt, J., Beckstette, M., Lipps, C., Wirth, D., Rohde, M., Pálóczi, K., Buzás, E. I., & Huehn, J. (2017) · European Journal of Immunology · doi:10.1002/eji.201746960 · Cited by 20 · see citing works
Dendritic cells in food allergy, treatment, and tolerance
Liu, E. G., Yin, X., Siniscalco, E. R., & Eisenbarth, S. C. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.06.017 · Cited by 19 · see citing works
Narros‐Fernández, P., Basavarajappa, S. C., & Walsh, P. T. (2023) · FEBS Journal · doi:10.1111/febs.16888 · Cited by 19 · see citing works
STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells
Li, Y., Liu, W., Guan, X., Truscott, J., Creemers, J. W. M., Chen, H.-L., Pesu, M., Abiad, R. G. E., Karaçay, B., Urban, J. F., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700808 · Cited by 17 · see citing works
West, C., Tobo, C., Au, J., Johnson, D., Mottaleb, M. A., Robinson, J., Shringarpure, S., Griggs, D. W., & Garg, K. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2023 · Cited by 16 · see citing works
van der Kraan, P. M. (2022) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2022.100238 · Cited by 14 · see citing works
Eisinger, K., Girke, P., Buechler, C., & Krautbauer, S. (2023) · Mammalian Genome · doi:10.1007/s00335-023-10022-3 · Cited by 14 · see citing works
Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration
Greenhalgh, S. N., Matchett, K. P., Taylor, R. S., Huang, K., Li, J. T., Saeteurn, K., Donnelly, M. C., Simpson, E. E. M., Pollack, J. L., Atakilit, A., et al. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.10.007 · Cited by 13 · see citing works
Self-citationSchuetz, A., Corley, M. J., Sacdalan, C., Phuang‐Ngern, Y., Nakpor, T., Wansom, T., Ehrenberg, P. K., Sriplienchan, S., Thomas, R., Ratnaratorn, N., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.169272 · Cited by 12 · see citing works
Zhou, Y., Takano, T., Wang, Y., Li, X., Wang, R., Wakatsuki, Y., Nakajima‐Adachi, H., Tanokura, M., Miyakawa, T., & Hachimura, S. (2020) · iScience · doi:10.1016/j.isci.2020.101883 · Cited by 12 · see citing works
Conventional type I migratory CD103+ dendritic cells are required for corneal allograft survival
Blanco, T., Singh, R. B., Nakagawa, H., Taketani, Y., Dohlman, T. H., Chen, Y., Chauhan, S. K., Yin, J., & Dana, R. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2022.12.002 · Cited by 9 · see citing works
Elfiky, A. M. I., Hageman, I., Becker, M. A. J., Verhoeff, J., Yim, A. Y. F. L., Joustra, V., Mulders, L., Fung, I. T. H., Rioja, I., Prinjha, R. K., et al. (2022) · Cells · doi:10.3390/cells11182846 · Cited by 7 · see citing works
Zhang, T., Peng, H., Li, Y., Zhou, X., Pu, W., Zhang, Y., Du, Z., Wei, F., Li, S., & Zhou, Q. (2022) · Phytotherapy Research · doi:10.1002/ptr.7595 · Cited by 7 · see citing works
Matthiesen, S., Christiansen, B., Jahnke, R., Zaeck, L. M., Karger, A., Finke, S., Franzke, K., & Knittler, M. R. (2023) · Infection and Immunity · doi:10.1128/iai.00323-22 · Cited by 7 · see citing works
Human Dendritic Cell Enrichment and Their Activation of T Cells
Lubin, R., Gvili, R., Hazan, I., & Yona, S. (2023) · Current Protocols · doi:10.1002/cpz1.873 · Cited by 4 · see citing works
Yang, X., Dai, J., Yang, Q., Wei, H., Song, H., Liu, L., Huang, Y., Wang, L., Chen, P., Chen, X., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106930 · Cited by 3 · see citing works
Langerin-expressing dendritic cells in pulmonary immune-related diseases
Xuan, S., Li, Y., Wu, Y., Adcock, I. M., Zeng, X., & Yao, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.909057 · Cited by 3 · see citing works
RNF43 is a gatekeeper for colitis-associated cancerPreprint
Dietl, A., Ralser, A., Taxauer, K., Dregelies, T., Sterlacci, W., Stadler, M., Olayo-Alarcón, R., Margaryan, S., Skerhut, M., Groll, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.30.577936 · Cited by 2 · see citing works
This, S., Brichart-Vernos, D., Väänänen, V. A., Rey, C., Barateau, V., Fenouil, T., Mörbe, U., Daniel, L., Nishimura, S. L., Graff‐Dubois, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.26.707908 · Cited by 1 · see citing works
Self-citationPaïdassi, H. (2017) · Revue française d'allergologie · doi:10.1016/j.reval.2017.02.016
CORTES. Thermal & Mechanical Analysis of Tees
Gantayat, A., Powell, G. H., Textor, R. E., Bass, B. R., Bryson, J. W., & Moore, S. E. (1973) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8
Seed, R., & Nishimura, S. L. (2022) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4385
Self-citationCytokines and Inflammatory Bowel Disease
de Zoeten, E. F., & Fuss, I. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-14744-9_3
McEntee, C. P., Houston, S. A., Finlay, C. M., Rossi, S., Liu, G., Shaw, T. N., Casulli, J., Fife, M. E., Smedley, C., Griffith, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.02.527395
Self-citationDendritic Cells: Phenotype, Ontogeny and Function
Cerovic, V., & Hager, F. T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00146-0
Yang, X. H., Liu, Y., Fu, C. S., Jin, H. M., & Ye, Z. B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1868198
BindingDB Entry 50009576: Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide.
BindingDB (2021) · UC San Diego · doi:10.7270/q26t0r53
- Authors
- Fenton, T. M., Kelly, A., Shuttleworth, E. E., Smedley, C., Atakilit, A., Powrie, F., Campbell, S., Nishimura, S. L., Sheppard, D., Levison, S., Worthington, J. J., Lehtinen, M. J., & Travis, M. A.
- Affiliations
- Wellcome Centre for Cell-Matrix Research (GB)
- University of California, San Francisco (US)
- University of Oxford (GB)
- Manchester Royal Infirmary (GB)
- University of Manchester (GB)
- DuPont (Finland) (FI)
- Corresponding author
- Travis, M.A.
- ORCID
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 10
- Issue
- 3
- Pages
- 624-634
- ISSN
- 1933-0219 (ISSN-L)
- PMC
- PMC5439516
- OpenAlex
- W2541536818
- Cited by
- 64
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 8
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (088785, 097820/Z11/B, 088785/Z/09/Z, 097820, 088785/Z/09)
- Manchester Collaborative Centre for Inflammation Research
- Directorate for Biological Sciences
- Medical Research Council (MR/M00242X/1, MR/L011840/1)
- Biotechnology and Biological Sciences Research Council (BB/G001103/1)
- National Heart, Lung, and Blood Institute (R01HL113032)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- integrin αvβ8, intestinal dendritic cells, CD1c+ dendritic cells, CD141+ dendritic cells, intestinal inflammation, inflammatory bowel disease, lipopolysaccharide, TLR4, Foxp3, regulatory T cells, microbial signals
- MeSH terms
- Adult, Aged, Cells, Cultured, Dendritic Cells, Female, Glycoproteins, Humans, Intestines, Lipopolysaccharides, Male, Middle Aged, Inflammatory Bowel Diseases, CD4-Positive T-Lymphocytes, Up-Regulation, Integrins, Transforming Growth Factor beta, Antigens, CD1, Toll-Like Receptor 4, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
