Kao, Aimee W.

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 367

Clinicopathological correlations in behavioural variant frontotemporal dementia

Perry, D. C., Brown, J. A., Possin, K. L., Datta, S., Trujillo, A., Radke, A., Karydas, A., Kornak, J., Sias, A. C., Rabinovici, G. D., et al. (2017) · Brain

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

Cited by 309

MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Bettcher, B. M., Fitch, R., Wynn, M. J., Lalli, M. A., Elofson, J., Jastrzab, L., Mitic, L., Miller, Z. A., Rabinovici, G. D., Miller, B. L., et al. (2016) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 89

Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease

Lalli, M. A., Bettcher, B. M., Arcila, M. L., Garcia, G., Guzman, C., Madrigal, L., Ramirez, L., Acosta-Uribe, J., Baena, A., Wojta, K. J., et al. (2015) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 73

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Alquezar, C., Schoch, K. M., Geier, E. G., Ramos, E. M., Scrivo, A., Li, K. H., Argouarch, A. R., Mlynarski, E. E., Dombroski, B., DeTure, M., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 56

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

Mohan, S., Sampognaro, P. J., Argouarch, A. R., Maynard, J. C., Welch, M., Patwardhan, A., Courtney, E. C., Zhang, J., Mason, A., Li, K. H., et al. (2021) · Molecular Neurodegeneration

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 49

Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Alquezar, C., Felix, J. B., McCandlish, E., Buckley, B. T., Caparros-Lefebvre, D., Karch, C. M., Golbe, L. I., & Kao, A. W. (2020) · Scientific Reports

Alzheimer's disease research and treatmentsHeavy Metal Exposure and Toxicity

Cited by 49

Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro

Butler, V. J., Cortopassi, W. A., Gururaj, S., Wang, A. L., Pierce, O. M., Jacobson, M. P., & Kao, A. W. (2019) · Biochemistry

Protease and Inhibitor MechanismsAlzheimer's disease research and treatments

Cited by 42

Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., Ashrafi, K., Cuervo, A. M., Jacobson, M. P., Coppola, G., et al. (2019) · PLOS Genetics

Genetics, Aging, and Longevity in Model OrganismsAmyotrophic Lateral Sclerosis Research

Cited by 39

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Sampognaro, P. J., Arya, S., Knudsen, G. M., Gunderson, E. L., Sandoval-Perez, A., Hodul, M., Bowles, K., Craik, C. S., Jacobson, M. P., & Kao, A. W. (2023) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 35

Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia

Liu, A. J., Staffaroni, A. M., Rojas-Martinez, J. C., Olney, N. T., Alquezar-Burillo, C., Ljubenkov, P. A., La Joie, R., Fong, J. C., Taylor, J., Karydas, A., et al. (2020) · JAMA Neurology

Tuberous Sclerosis Complex ResearchDementia and Cognitive Impairment Research

Cited by 18

Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia

Olney, N. T., Alquezar, C., Ramos, E. M., Nana, A. L., Fong, J. C., Karydas, A. M., Taylor, J. B., Stephens, M. L., Argouarch, A. R., Van Berlo, V. A., et al. (2017) · Acta Neuropathologica

Tuberous Sclerosis Complex ResearchAlzheimer's disease research and treatments

Cited by 15

Tuberous sclerosis complex is associated with a novel human tauopathy

Hwang, J.-H. L., Perloff, O. S., Gaus, S. E., Benitez, C., Alquezar, C., Cosme, C. Q., Nana, A. L., Vatsavayai, S. C., Ramos, E. M., Geschwind, D. H., et al. (2023) · Acta Neuropathologica

Tuberous Sclerosis Complex ResearchAlzheimer's disease research and treatments

Cited by 15

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M.-A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., et al. (2025) · Nature Communications

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 12

The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases

Lane-Donovan, C., Paredes, M., & Kao, A. W. (2025) · Progress in Neurobiology

Lysosomal Storage Disorders ResearchAutophagy in Disease and Therapy

Cited by 3