Pirmohamed, Munir

Drug repurposing: progress, challenges and recommendations

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., Doig, A., Guilliams, T., Latimer, J., McNamee, C., et al. (2019) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsPharmaceutical Economics and Policy

Cited by 4,718

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Laverty, H., Benson, C., Cartwright, E., Cross, M., Garland, C., Hammond, T., Holloway, C., McMahon, N., Milligan, J., Park, B., et al. (2011) · British Journal of Pharmacology

Animal testing and alternativesCardiac electrophysiology and arrhythmias

Cited by 363

Genetic susceptibility to adverse drug reactions

Pirmohamed, M., & Park, B. K. (2001) · Trends in Pharmacological Sciences

Pharmacogenetics and Drug MetabolismDrug-Induced Adverse Reactions

Cited by 328

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

Park, B. K., Pirmohamed, M., & Kitteringham, N. R. (1998) · Chemical Research in Toxicology

Drug-Induced Adverse ReactionsPharmacogenetics and Drug Metabolism

Cited by 267

Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., Goenka, N., Thomas, E. L., Adams, V. L., Pushpakom, S. P., et al. (2012) · PLoS ONE

Diabetes Treatment and ManagementLiver Disease Diagnosis and Treatment

Cited by 226

Phenotype standardization for statin-induced myotoxicity

Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., Carr, D. F., Bloch, K. M., Fahy, J., Hanson, A., et al. (2014) · Clinical Pharmacology & Therapeutics

Lipoproteins and Cardiovascular HealthMuscle and Compartmental Disorders

Cited by 220

Antibiotic Allergy

Gruchalla, R. S., & Pirmohamed, M. (2006) · New England Journal of Medicine

Drug-Induced Adverse ReactionsPharmacovigilance and Adverse Drug Reactions

Cited by 204

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2002) · Molecular Pharmacology

Drug-Induced Adverse ReactionsImmunotoxicology and immune responses

Cited by 141

Drug-grapefruit juice interactions

Pirmohamed, M. (2013) · BMJ

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 140

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001) · British Journal of Pharmacology

Drug-Induced Adverse ReactionsContact Dermatitis and Allergies

Cited by 133

Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital

Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014) · British Journal of Clinical Pharmacology

Pharmaceutical studies and practicesPharmacovigilance and Adverse Drug Reactions

Cited by 120

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2007) · Journal of Allergy and Clinical Immunology

Drug-Induced Adverse ReactionsT-cell and B-cell Immunology

Cited by 115

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation

Gill, H. J., Tjia, J. F., Kitteringham, N. R., Pirmohamed, M., Back, D. J., & Park, B. K. (1999) · Pharmacogenetics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 48

GATM gene variants and statin myopathy risk

Carr, D. F., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014) · Nature

Pharmacogenetics and Drug MetabolismLipoproteins and Cardiovascular Health

Cited by 35

The Association Between Polymorphisms in RLIP76 and Drug Response in Epilepsy

Leschziner, G. D., Jorgensen, A. L., Andrew, T., Williamson, P. R., Marson, A. G., Coffey, A. J., Middleditch, C., Balding, D. J., Rogers, J., Bentley, D. R., et al. (2007) · Pharmacogenomics

Epilepsy research and treatmentPharmacogenetics and Drug Metabolism

Cited by 18

Open letter on access to the BIA 10-2474 clinical trial data

Brøsen, K., Funck-Brentano, C., Kroemer, H. K., Pirmohamed, M., & Schwab, M. (2017) · The Lancet

Ethics in Clinical ResearchBiomedical Ethics and Regulation

Cited by 12