Yakar, Shoshana

Circulating levels of IGF-1 directly regulate bone growth and density

Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J.-L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., et al. (2002) · Journal of Clinical Investigation

Growth Hormone and Insulin-like Growth FactorsBone Metabolism and Diseases

Cited by 739

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 631

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Fernández, A. M., Kim, J. K., Yakar, S., Dupont, J., Hernandez-Sanchez, C., Castle, A. L., Filmore, J., Shulman, G. I., & Le Roith, D. (2001) · Genes & Development

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

Cited by 369

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1

LeRoith, D., & Yakar, S. (2007) · Nature Clinical Practice Endocrinology & Metabolism

Growth Hormone and Insulin-like Growth FactorsFibroblast Growth Factor Research

Cited by 344

The intricate role of growth hormone in metabolism

Vijayakumar, A., Yakar, S., & LeRoith, D. (2011) · Frontiers in Endocrinology

Growth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

Cited by 179

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model

Alikhani, N., Ferguson, R. D., Novosyadlyy, R., Gallagher, E. J., Scheinman, E. J., Yakar, S., & LeRoith, D. (2013) · Oncogene

Cancer, Lipids, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 146

The role of insulin receptor signaling in zebrafish embryogenesis

Toyoshima, Y., Monson, C., Duan, C., Wu, Y., Gao, C., Yakar, S., Sadler, K. C., & LeRoith, D. (2008) · Endocrinology

Developmental Biology and Gene RegulationGrowth Hormone and Insulin-like Growth Factors

Cited by 72

Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan

Duran‐Ortiz, S., List, E. O., Ikeno, Y., Young, J., Basu, R., Bell, S., McHugh, T., Funk, K., Mathes, S., Qian, Y., et al. (2021) · Aging Cell

Growth Hormone and Insulin-like Growth FactorsGenetics, Aging, and Longevity in Model Organisms

Cited by 58

Recombinant Human Insulin-Like Growth Factor-I Treatment Inhibits Gluconeogenesis in a Transgenic Mouse Model of Type 2 Diabetes Mellitus

Pennisi, P., Gavrilova, O., Setser-Portas, J., Jou, W., Santopietro, S., Clemmons, D., Yakar, S., & LeRoith, D. (2006) · Endocrinology

Growth Hormone and Insulin-like Growth FactorsDiabetes Treatment and Management

Cited by 51