Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,754 · see citing works

Effects of Human Growth Hormone in Men over 60 Years Old

Rudman, D. R., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230101 · Cited by 1,551 · see citing works

Normal growth and development in the absence of hepatic insulin-like growth factor I

Yakar, S., Liu, J., STANNARD, B. S., Butler, A. A., Accili, D., Sauer, B., & LeRoith, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7324 · Cited by 1,418 · see citing works

Increased mortality associated with growth hormone treatment in critically ill adults

Takala, J., Ruokonen, E., Webster, N. R., Nielsen, M. S., Zandstra, D. F., Vundelinckx, G., & Hinds, C. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909093411102 · Cited by 1,023 · see citing works

INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS

Akala, J. U. T., Uokonen, E. S. R., Igel, N., Ebster, R. W., Ielsen, M. I. S. N., Andstra, D. U. F. Z., Undelinckx, G. U. V., & Inds, H. J. H. (1999) · Cited by 889 · see citing works

Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.

Bengtsson, B. Å., Edén, S., Lönn, L., Kvist, H., Stokland, A. M., Lindstedt, G., Bosaeus, I. G., Tölli, J., Sjöström, L., & Isaksson, O. G. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432773 · Cited by 780 · see citing works

Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth

Lupu, F. I., Terwilliger, J. D., Lee, K., Segre, G. V., & Efstratiadis, A. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9975 · Cited by 769 · see citing works

Fat cell adrenergic receptors and the control of white and brown fat cell function

Lafontan, M., & Berlan, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37695-1 · Cited by 636 · see citing works

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice ¹

Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works

Targeted Disruption of the β3-Adrenergic Receptor Gene

Susulic, V. S., Frederich, R. C., Lawitts, J. A., Tozzo, E., Kahn, B. B., Harper, M., Himms‐Hagen, J., Flier, J. S., & Lowell, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29483 · Cited by 493 · see citing works

EFFECT OF GROWTH HORMONE ON PLASMA FATTY ACIDS*

Raben, M. S., & Hollenberg, C. H. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103824 · Cited by 448 · see citing works

Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle

Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442 · see citing works

Human growth hormone prevents the protein catabolic side effects of prednisone in humans.

Horber, F., & Haymond, M. W. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114694 · Cited by 405 · see citing works

Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity

Yakar, S., Liu, J., Fernandez, A. M., Wu, Y., Schally, A. V., Frystyk, J., Chernausek, S. D., Mejía, W., & Roith, D. L. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1110 · Cited by 343 · see citing works

Growth Hormone Treatment of Abdominally Obese Men Reduces Abdominal Fat Mass, Improves Glucose and Lipoprotein Metabolism, and Reduces Diastolic Blood Pressure1

Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., Björntorp, P. A., Sjöström, L., & Bengtsson, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3809 · Cited by 336 · see citing works

Effect of Growth Hormone Treatment on the Adult Height of Children with Chronic Renal Failure

Haffner, D., Schaefer, F. S., Nissel, R., Wühl, E., Tönshoff, B., & Mehls, O. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431304 · Cited by 301 · see citing works

Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes

Moses, A. C., Young, S. C., Morrow, L. A., O'Brien, M., & Clemmons, D. R. (1996) · Diabetes · doi:10.2337/diab.45.1.91 · Cited by 291 · cited 1× · see citing works

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

Rudling, M. J., Norstedt, G., Olivecrona, H., Reihnér, E., Gustafsson, J.-Α., & Angelin, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6983 · Cited by 269 · see citing works

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

Yakar, S., Setser, J., Zhao, H., STANNARD, B. S., Haluzı́k, M., Glatt, V., Bouxsein, M., Kopchick, J. J., & LeRoith, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci17763 · Cited by 249 · see citing works

Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice

Liu, J., Coschigano, K. T., Robertson, K., Lipsett, M. A., Guo, Y., Kopchick, J. J., Kumar, U., & Liu, Y. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00423.2003 · Cited by 218 · see citing works

Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction

Dupont, J., & LeRoith, D. (2001) · Hormone Research in Paediatrics · doi:10.1159/000063469 · Cited by 217 · see citing works

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

Clemmons, D. R. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20660 · Cited by 202 · see citing works

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice

Yakar, S., Setser, J., Zhao, H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200417763 · Cited by 201 · see citing works

Importance of Raised Growth Hormone Levels in Mediating the Metabolic Derangements of Diabetes

Press, M., Tamborlane, W. V., & Sherwin, R. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403293101302 · Cited by 198 · see citing works

Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance

Jørgensen, J. O. L., Thuesen, L., Müller, J., Ovesen, P., Skakkebæk, N. E., & Christiansen, J. S. (1994) · European Journal of Endocrinology · doi:10.1530/eje.0.1300224 · Cited by 179 · see citing works

Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.

Hussain, M. A., Schmitz, O., Mengel, A., Keller, A., Christiansen, J. S., Zapf, J., & Froesch, E. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116828 · Cited by 170 · see citing works

Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle

Louard, R. J., Fryburg, D. A., Gelfand, R. A., & Barrett, E. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116124 · Cited by 169 · see citing works

Insulin-Like Growth Factor-I Stimulates Both Cell Growth and Lipogenesis during Differentiation of Human Mesenchymal Stem Cells into Adipocytes

Scavo, L. M., Karas, M., Murray, M., & LeRoith, D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031682 · Cited by 157 · see citing works

Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

Cola, G. D., Cool, M. H., & Accili, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119438 · Cited by 156 · see citing works

Growth Hormone Treatment Reduces Abdominal Visceral Fat in Postmenopausal Women with Abdominal Obesity: A 12-Month Placebo-Controlled Trial

Franco, C., Brandberg, J., Lönn, L., Andersson, B., Bengtsson, B., & Johannsson, G. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1657 · Cited by 151 · see citing works

Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.

Zenobi, P. D., Graf, S., Ursprung, H., & Froesch, E. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115796 · Cited by 135 · see citing works

Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man

Turkalj, I., Keller, U. B., Ninnis, R., Vosmeer, S., & Stauffacher, W. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.5.1430077 · Cited by 133 · see citing works

Are the metabolic effects of GH and IGF-I separable?

Mauras, N., & Haymond, M. W. (2005) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.12.003 · Cited by 131 · see citing works

The Combination of Insulin-Like Growth Factor I and Insulin-Like Growth Factor-Binding Protein-3 Reduces Insulin Requirements in Insulin-Dependent Type 1 Diabetes: Evidence forin VivoBiological Activity1

Clemmons, D. R., Moses, A. C., McKay, M. J., Sommer, A., Rosen, D. M., & Ruckle, J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6559 · Cited by 128 · see citing works

GROWTH HORMONE AND THE METABOLISM OF CARBOHYDRATE AND LIPID IN ADIPOSE TISSUE*

GOODMAN, H. M. (1968) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1968.tb20367.x · Cited by 124 · see citing works

Insulin-Like Growth Factor I and Growth Hormone (GH) Treatment in GH-Deficient Humans: Differential Effects on Protein, Glucose, Lipid, and Calcium Metabolism1

Mauras, N., O'Brien, K. O., Welch, S., Rini, A., Helgeson, K., Vieira, N. E., & Yergey, A. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6541 · Cited by 117 · see citing works

Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice

Dominici, F. P., Diaz, G. A., Bartke, A., Kopchick, J., & Turyn, D. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660579 · Cited by 116 · see citing works

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex

Haluzı́k, M., Yakar, S., Gavrilova, O., Setser, J., Boisclair, Y. R., & LeRoith, D. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2483 · Cited by 116 · see citing works

IGFs and IGFBPs: role in health and disease

Monzavi, R., & Cohen, P. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0212 · Cited by 115 · see citing works

Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

Zick, Y. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320812 · Cited by 115 · see citing works

Wasting in the acquired immune deficiency syndrome is associated with multiple defects in the serum insulin‐like growth factor system

Frost, R. A., Fuhrer, J., Steigbigel, R. T., Mariuz, P., Lang, C. H., & Gelato, M. C. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.705526.x · Cited by 99 · see citing works

Action of Growth Hormone in Adipose Tissue

Richelsen, B. (1997) · Hormone Research · doi:10.1159/000191338 · Cited by 94 · see citing works

Growth hormone receptor antagonist improves insulin resistance in acromegaly

Rose, D. R., & Clemmons, D. R. (2002) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(02)00083-7 · Cited by 90 · see citing works

Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance

Morrow, L., O'Brien, M. B., Moller, D. E., Flier, J. S., & Moses, A. C. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027228 · Cited by 88 · see citing works

Low-Dose Growth Hormone Treatment with Diet Restriction Accelerates Body Fat Loss, Exerts Anabolic Effect and Improves Growth Hormone Secretory Dysfunction in Obese Adults

Kim, K. R., Nam, S. Y., Song, Y. D., Lim, S. K., Lee, H. C., & Huh, K. B. (1999) · Hormone Research in Paediatrics · doi:10.1159/000023319 · Cited by 86 · see citing works

Insulin-like growth factor binding proteins as glucoregulators

Baxter, R. C. (1995) · Metabolism · doi:10.1016/0026-0495(95)90215-5 · Cited by 79 · see citing works

Growth hormone has anabolic effects in glucocorticosteroid-dependent children with inflammatory bowel disease: A pilot study

Mauras, N., George, D. E., Evans, J., Milov, D. E., Abrams, S. A., Rini, A., Welch, S., & Haymond, M. W. (2002) · Metabolism · doi:10.1053/meta.2002.28972 · Cited by 78 · see citing works

The Decisive Role of Free Fatty Acids for Protein Conservation during Fasting in Humans with and without Growth Hormone

Nørrelund, H., Nair, K. S., Nielsen, S., Frystyk, J., Ivarsen, P., Jørgensen, J. O. L., Christiansen, J. S., & Møller, N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030267 · Cited by 70 · see citing works

Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance

Ranke, M. B. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.03.011 · Cited by 62 · see citing works

Inhibition of the Rise in FFA by Acipimox Partially Prevents GH-Induced Insulin Resistance in GH-Deficient Adults

Segerlantz, M., Bramnert, M., Manhem, P., Laurila, E., & Groop, L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8096 · Cited by 61 · see citing works

Pancreatic Islet-Specific Expression of an Insulin-Like Growth Factor-I Transgene Compensates Islet Cell Growth in Growth Hormone Receptor Gene-Deficient Mice

Guo, Y., Lu, Y., Houle, D., Robertson, K., Tang, Z., Kopchick, J. J., Liu, Y. L., & Liu, J. (2005) · Endocrinology · doi:10.1210/en.2004-1203 · Cited by 60 · see citing works

Physical and Functional Interaction of Growth Hormone and Insulin-Like Growth Factor-I Signaling Elements

Huang, Y., Kim, S.-O., Yang, N., Jiang, J., & Frank, S. J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0418 · Cited by 59 · see citing works

Effects of low-dose recombinant human insulin-like growth factor-I on insulin sensitivity, growth hormone and glucagon levels in young adults with insulin-dependent diabetes mellitus

Acerini, C. L., Harris, D. A., Matyka, K. A., Watts, A., Umpleby, A. M., Russell-Jones, D. L., & Dunger, D. B. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90074-9 · Cited by 53 · see citing works

Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting

Mulligan, K. M., & Schambelan, M. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00247-4 · Cited by 52 · see citing works

Low-Dose Recombinant Human Growth Hormone as Adjuvant Therapy to Lifestyle Modifications in the Management of Obesity

Albert, S. G., & Mooradian, A. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031264 · Cited by 48 · see citing works

GH but not IGF-I or insulin increases lipoprotein lipase activity in muscle tissues of hypophysectomised rats

Oscarsson, J., Ottosson, M., Vikman, K., Frick, F., Enerbäck, S., Lithell, H., & Edén, S. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600247 · Cited by 47 · see citing works

Relationship between lipolysis and cyclic AMP generation mediated by atypical β‐adrenoceptors in rat adipocytes

Hollenga, C., Brouwer, F., & Zaagsma, J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12215.x · Cited by 43 · see citing works

The Effects of Short-Term Administration of Two Low Doses Versus the Standard GH Replacement Dose on Insulin Sensitivity and Fasting Glucose Levels in Young Healthy Adults

Yuen, K. C. J., Ong, K. K., Husbands, S., Chatelain, P., Fryklund, L., Gluckman, P. D., Ranke, M. B., Cook, D. M., Rosenfeld, R. G., Wass, J. A. H., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8460 · Cited by 34 · see citing works

Combined recombinant human growth hormone and recombinant human insulin-like growth factor I: lack of synergy on whole body protein anabolism in normally fed subjects.

Mauras, N. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.9.7673406 · Cited by 31 · see citing works

The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice

Heffernan, M., Summers, R. J., Thorburn, A. W., Ogru, E., Gianello, R., Jiang, W., & Ng, F. M. (2001) · Endocrinology · doi:10.1210/endo.142.12.8522 · Cited by 31 · see citing works

Changes in IGF-I receptor and IGF-I mRNA during differentiation of 3T3-L1 preadipocytes

Zizola, C. F., Balañá, M. E., Sandoval, M., & Calvo, J. C. (2002) · Biochimie · doi:10.1016/s0300-9084(02)00009-3 · Cited by 28 · see citing works

Regional Fat Distribution by Dual-Energy X-Ray Absorptiometry: Comparison with Anthropometry and Application in a Clinical Trial of Growth Hormone and Exercise

Taaffe, D. R., Lewis, B., & Marcus, R. (1994) · Clinical Science · doi:10.1042/cs0870581 · Cited by 26 · see citing works

Changes in Free Rather Than Total Insulin-Like Growth Factor-I Enhance Insulin Sensitivity and Suppress Endogenous Peak Growth Hormone (GH) Release following Short-Term Low-Dose GH Administration in Young Healthy Adults

Yuen, K. C. J., Frystyk, J., Umpleby, A. M., Fryklund, L., & Dunger, D. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0300 · Cited by 26 · see citing works

Insulin Therapy Increases Low Plasma Growth Hormone Binding Protein in Children with New‐onset Type 1 Diabetes

Arslanian, S. A., Menon, R. K., Gierl, A. P., Heil, B. V., & Foley, T. P. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00175.x · Cited by 25 · see citing works

Use of Growth Hormone and Other Anabolic Agents in AIDS Wasting

Mulligan, K. M., Tai, V., & Schambelan, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300606 · Cited by 23 · see citing works

Use of Growth Hormone and Insulin-Like Growth Factor I in Catabolism That Is Induced by Negative Energy Balance

Clemmons, D. R. (2008) · Hormone Research · doi:10.1159/000183769 · Cited by 19 · see citing works

Recombinant Human Growth Hormone, But Not Insulin-Like Growth Factor-I, Enhances Central Fat Loss in Postmenopausal Women Undergoing a Diet and Exercise Program

Taaffe, D. R., Thompson, J. L., Butterfield, G. E., Hoffman, A. R., & Marcus, R. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-14930 · Cited by 17 · see citing works

Recombinant, Nonglycosylated Human Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) Is Degraded Preferentially after Administration to Type II Diabetics, Resulting in Increased Endogenous Glycosylated IGFBP-3

Clemmons, D. R., Sleevi, M., & Busby, W. H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1389 · Cited by 14 · see citing works

Insulin-Like Growth Factor Binding Protein-1: Identification, Purification, and Regulation in Fetal and Adult Life

Unterman, T. G. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2988-0_21 · Cited by 12 · see citing works

The use of growth hormone in severely ill patients.

Dw, W. (1999) · PubMed · Cited by 9 · see citing works

Physiological effects and potential applications of GH and IGF-I.

Da, F., & Ej, B. (1999) · PubMed · Cited by 3 · see citing works

Metabolic Effects of rhIGF-1 in Normal Human Subjects

Rennert, N. J., Boulware, S. D., Kerr, D. E., Caprio, S., Tamborlane, W. V., & Sherwin, R. S. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-2988-0_30 · Cited by 2 · see citing works

Diabetes and cancer

Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009 · see citing works

Acromegaly pathogenesis and treatment

Melmed, S. K. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39375 · Cited by 690 · see citing works

Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton, G. M., Koza, R. A., Chouljenko, V. N., Kousoulas, K. G., Rogers, P. M., Kesterson, R. A., Thearle, M. S., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.011 · Cited by 511 · see citing works

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.05.006 · Cited by 409 · see citing works

Consensus Statement on the Standardization and Evaluation of Growth Hormone and Insulin-like Growth Factor Assays

Clemmons, D. R. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.150631 · Cited by 352 · see citing works

Insulin-like growth factor-1 deficiency and metabolic syndrome

Aguirre, G. A., Ita, J. R. D., de la Garza, R. G., & Castilla‐Cortázar, I. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-015-0762-z · Cited by 297 · see citing works

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

Kappeler, L., Filho, C. D. D. M., Dupont, J., Leneuve, P., Cervera, P., Périn, L., Loudes, C., Blaise, A., Klein, R., Epelbaum, J., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060254 · Cited by 289 · see citing works

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

Gunawardana, S. C., & Piston, D. W. (2012) · Diabetes · doi:10.2337/db11-0510 · Cited by 290 · see citing works

Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance

Kumar, K. G., Zhang, J., Gao, S., Rossi, J., McGuinness, O. P., Halem, H. H., Culler, M. D., Mynatt, R. L., & Butler, A. A. (2012) · Obesity · doi:10.1038/oby.2012.31 · Cited by 262 · see citing works

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism

Fan, Y., Menon, R. K., Cohen, P., Hwang, D., Clemens, T. L., DiGirolamo, D. J., Kopchick, J. J., Roith, D. L., Trucco, M., & Sperling, M. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014308 · Cited by 255 · see citing works

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer

Kasprzak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126434 · Cited by 248 · see citing works

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

O-Sullivan, I., Zhang, W., Wasserman, D. H., Liew, C. W., Liu, J., Paik, J., DePinho, R. A., Stolz, D. B., Kahn, C. R., Schwartz, M. W., et al. (2015) · Nature Communications · doi:10.1038/ncomms8079 · Cited by 228 · see citing works

Phenotypes of prediabetes and stratification of cardiometabolic risk

Stefan, N., Fritsche, A., Schick, F., & Häring, H.-U. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)00082-6 · Cited by 208 · see citing works

IGF-1R as an anti-cancer target--trials and tribulations

Chen, H. X., & Sharon, E. (2013) · 癌症：英文版 · doi:10.5732/cjc.012.10263 · Cited by 201 · see citing works

The IGF system

Annunziata, M., Granata, R., & Ghigo, E. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0227-z · Cited by 197 · see citing works

The current status of IGF-I assays – A 2009 update

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