Nakagawa, Takashi

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,635

SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

Nakagawa, T., Lomb, D. J., Haigis, M. C., & Guarente, L. (2009) · Cell

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 787

NAD metabolism: Implications in aging and longevity

Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Ageing Research Reviews

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 269

Implications of altered NAD metabolism in metabolic disorders

Okabe, K., Yaku, K., Tobe, K., & Nakagawa, T. (2019) · Journal of Biomedical Science

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 223

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

Sasaki, Y., Nakagawa, T., Mao, X., DiAntonio, A., & Milbrandt, J. (2016) · eLife

Nerve injury and regenerationSirtuins and Resveratrol in Medicine

Cited by 192

Mitochondrial membrane permeability transition and cell death

Tsujimoto, Y., Nakagawa, T., & Shimizu, S. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 188

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia

Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism

Sirtuins and Resveratrol in MedicineNutrition and Health in Aging

Cited by 148

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K., & Nakagawa, T. (2022) · Frontiers in Nutrition

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 105

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Yaku, K., Palikhe, S., Izumi, H., Yoshida, T., Hikosaka, K., Hayat, F., Karim, M., Iqbal, T., Nitta, Y., Sato, A., et al. (2021) · Nature Communications

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 76

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Matsui, S., Sasaki, T., Kohno, D., Yaku, K., Inutsuka, A., Yokota-Hashimoto, H., Kikuchi, O., Suga, T., Kobayashi, M., Yamanaka, A., et al. (2018) · Nature Communications

Sirtuins and Resveratrol in MedicineRegulation of Appetite and Obesity

Cited by 72

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience

Sirtuins and Resveratrol in MedicineNuclear Receptors and Signaling

Cited by 62

Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD + synthesis via enterohepatic circulation

Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., et al. (2025) · Science Advances

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 40