Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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The Free Radical Theory of Aging

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PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

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Vitamin B ₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

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Mitochondrial dysfunction in Parkinson's disease

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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma

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SARM1 activation triggers axon degeneration locally via NAD ⁺ destruction

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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

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NAD ⁺ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

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Individual variability in human blood metabolites identifies age-related differences

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Peripheral neuropathy

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Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

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A local mechanism mediates NAD-dependent protection of axon degeneration

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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

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The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinson's disease

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Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

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Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

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Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

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Slc12a8 is a nicotinamide mononucleotide transporter

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A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

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Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

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NAD metabolism: Implications in aging and longevity

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An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

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Role of metabolism in neurodegenerative disorders

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NAD ⁺ repletion improves muscle function in muscular dystrophy and counters global PARylation

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A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

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Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

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Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

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Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

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Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

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NMNAT1 mutations cause Leber congenital amaurosis

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Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

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The Plasma NAD + Metabolome Is Dysregulated in “Normal” Aging

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The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson's disease

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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

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NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

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Neurodegeneration as a consequence of failed mitochondrial maintenance

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Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

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Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

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Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

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Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

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A Genomewide Screen for Late-Onset Alzheimer Disease in a Genetically Isolated Dutch Population

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Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration

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Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration<i>In Vivo</i>

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Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy

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Wlds mice are resistant to paclitaxel (taxol) neuropathy

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Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

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Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease

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Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

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Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress

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The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

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SARM1-specific motifs in the TIR domain enable NAD + loss and regulate injury-induced SARM1 activation

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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

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Relative importance of redox buffers GSH and NAD (P)H in age‐related neurodegeneration and Alzheimer disease‐like mouse neurons

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Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

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Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

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Sarm1 Deletion, but Not Wld, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

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A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4.

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Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

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SIRT3 and mitochondrial metabolism in neurodegenerative diseases

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Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration

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Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

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CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

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Nmnat2 Attenuates Tau Phosphorylation Through Activation of PP2A

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NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype

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