Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00313-x · Cited by 1,617 · see citing works

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · see citing works

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.013 · Cited by 930 · see citing works

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750 · see citing works

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Trammell, S. A. J., Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E., & Brenner, C. (2016) · Nature Communications · doi:10.1038/ncomms12948 · Cited by 697 · see citing works

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630 · see citing works

NAD+ homeostasis in health and disease

Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627 · see citing works

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-03421-7 · Cited by 588 · see citing works

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564 · see citing works

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

Würtz, P., Soininen, P., Kangas, A. J., Rönnemaa, T., Lehtimäki, T. J., Kähönen, M. A. P., Viikari, J. S. A., Raitakari, O. T., & Ala‐Korpela, M. (2012) · Diabetes Care · doi:10.2337/dc12-0895 · Cited by 549 · see citing works

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Elhassan, Y. S., Kluckova, K., Fletcher, R. S., Schmidt, M. S., Garten, A., Doig, C. L., Cartwright, D. M., Oakey, L., Burley, C. V., Jenkinson, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.043 · Cited by 448 · see citing works

Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents

McCormack, S. E., Shaham, O., McCarthy, M. A., Deik, A., Wang, T. J., Gerszten, R. E., Clish, C. B., Mootha, V. K., Grinspoon, S. K., & Fleischman, A. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00087.x · Cited by 439 · see citing works

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science · doi:10.1126/science.abe9985 · Cited by 439 · see citing works

Biosynthesis of Diphosphopyridine Nucleotide

Preiss, J., & Handler, P. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64790-8 · Cited by 408 · see citing works

Biosynthesis of Diphosphopyridine Nucleotide

Preiss, J., & Handler, P. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64789-1 · Cited by 403 · see citing works

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201403943 · Cited by 385 · see citing works

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Gariani, K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan, N., Zhang, H., Perino, A., Lemos, V., et al. (2016) · Hepatology · doi:10.1002/hep.28245 · Cited by 368 · see citing works

Calorie restriction as an intervention in ageing

López‐Lluch, G., & Navas, P. (2015) · The Journal of Physiology · doi:10.1113/jp270543 · Cited by 290 · see citing works

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

Dollerup, O. L., Christensen, B., Svart, M., Schmidt, M. S., Sulek, K., Ringgaard, S., Stødkilde-Jørgensen, H., Møller, N., Brenner, C., Treebak, J. T., et al. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy132 · Cited by 282 · see citing works

Activation of SIRT3 by the NAD(+) precursor nicotinamide riboside protects from noise-induced hearing loss

Brown, K. D., Maqsood, S., Huang, J.-Y., Pan, Y., Harkcom, W., Li, W., Sauve, A., Verdin, E., & Jaffrey, S. R. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.003 · Cited by 277 · see citing works

Safety considerations with niacin therapy

Guyton, J. R., & Bays, H. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.018 · Cited by 269 · see citing works

NAD metabolism: Implications in aging and longevity

Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.006 · Cited by 269 · see citing works

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Airhart, S. E., Shireman, L. M., Risler, L. J., Anderson, G. D., Gowda, G. A. N., Raftery, D., Tian, R., Shen, D. D., & O’Brien, K. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186459 · Cited by 260 · see citing works

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

Shats, I., Williams, J. G., Liu, J., Makarov, M. V., Wu, X., Lih, F. B., Deterding, L. J., Lim, C., Xu, X., Randall, T. A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.001 · Cited by 242 · see citing works

The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

Bird, J. G., Zhang, Y., Tian, Y., Panova, N., Barvı́k, I., Greene, L., Liu, M., Buckley, B., Krásný, L., Lee, J. K., et al. (2016) · Nature · doi:10.1038/nature18622 · Cited by 226 · see citing works

5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding

Jiao, X., Doamekpor, S. K., Bird, J. G., Nickels, B. E., Tong, L., Hart, R. P., & Kiledjian, M. (2017) · Cell · doi:10.1016/j.cell.2017.02.019 · Cited by 225 · see citing works

Implications of altered NAD metabolism in metabolic disorders

Okabe, K., Yaku, K., Tobe, K., & Nakagawa, T. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0527-8 · Cited by 223 · see citing works

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

Zhou, B., Wang, D. D.-H., Qiu, Y., Airhart, S. E., Liu, Y., Stempien‐Otero, A., O’Brien, K. D., & Tian, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138538 · Cited by 212 · see citing works

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

Conze, D., Brenner, C., & Kruger, C. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46120-z · Cited by 210 · see citing works

LC/MS analysis of cellular RNA reveals NAD-linked RNA

Chen, Y. G., Kowtoniuk, W. E., Agarwal, I., Shen, Y., & Liu, D. R. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.235 · Cited by 205 · see citing works

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, S. A. J., Perlman, S., Cohen, M. S., Fehr, A. R., & Brenner, C. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015138 · Cited by 192 · see citing works

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., et al. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej19-0313 · Cited by 191 · see citing works

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0016-9 · Cited by 181 · see citing works

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie, C. M., Roumans, K. H., Moonen, M. P., Connell, N. J., Havekes, B., Mevenkamp, J., Lindeboom, L., de Wit, V. H., van de Weijer, T., Aarts, S. A., et al. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa072 · Cited by 160 · see citing works

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin‐resistant men

Dollerup, O. L., Chubanava, S., Agerholm, M., Søndergård, S. D., Altıntaş, A., Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde‐Jørgensen, H., Lavery, G. G., et al. (2020) · The Journal of Physiology · doi:10.1113/jp278752 · Cited by 145 · see citing works

Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study

Dolopikou, C. F., Kourtzidis, I. A., Margaritelis, N. V., Vrabas, I. S., Koidou, E., Kyparos, A., Theodorou, A. A., Paschalis, V., & Nikolaidis, M. G. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01919-4 · Cited by 104 · see citing works

Serum amino acid profiles and risk of type 2 diabetes among Japanese adults in the Hitachi Health Study

Chen, S., Akter, S., Kuwahara, K., Matsushita, Y., Nakagawa, T., Konishi, M., Honda, T., Yamamoto, S., Hayashi, T., Noda, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43431-z · Cited by 102 · see citing works

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

Liao, B., Zhao, Y., Wang, D., Zhang, X., Xuan-ming, H., & Hu, M. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00442-4 · Cited by 96 · see citing works

Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19

Altay, O., Arif, M., Li, X., Yang, H., Aydın, M., Alkurt, G., Kim, W., Akyol, D., Zhang, C., Dinler‐Doganay, G., et al. (2021) · Advanced Science · doi:10.1002/advs.202101222 · Cited by 88 · see citing works

Liver fat reduction with niacin is influenced by DGAT-2 polymorphisms in hypertriglyceridemic patients

Hu, M., Chu, C. W., Yamashita, S., Yeung, D. K. W., Shi, L., Wang, D., Masuda, D., Yang, Y., & Tomlinson, B. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p023614 · Cited by 82 · see citing works

Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity

Dollerup, O. L., Trammell, S. A. J., Hartmann, B., Holst, J. J., Christensen, B., Møller, N., Gillum, M. P., Treebak, J. T., & Jessen, N. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01081 · Cited by 77 · see citing works

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Yaku, K., Palikhe, S., Izumi, H., Yoshida, T., Hikosaka, K., Hayat, F., Karim, M., Iqbal, T., Nitta, Y., Sato, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27080-3 · Cited by 76 · see citing works

Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells

Bender, D. A., & Olufunwa, R. (1988) · British Journal Of Nutrition · doi:10.1079/bjn19880035 · Cited by 64 · see citing works

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1637504 · Cited by 62 · see citing works

NAD+ in COVID-19 and viral infections

Zheng, M., Schultz, M. B., & Sinclair, D. A. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.02.001 · Cited by 62 · see citing works

Estimating Energy Expenditure from Heart Rate in Older Adults: A Case for Calibration

Schrack, J. A., Zipunnikov, V. M., Goldsmith, J., Bandeen‐Roche, K., Crainiceanu, C. M., & Ferrucci, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093520 · Cited by 51 · see citing works

Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem‐mass spectrometry

Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Biomedical Chromatography · doi:10.1002/bmc.4205 · Cited by 49 · see citing works

Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

Šimić, P., Parada, X. F. V., Parikh, S. M., Dellinger, R. W., Guarente, L., & Rhee, E. P. (2020) · BMC Nephrology · doi:10.1186/s12882-020-02006-1 · Cited by 41 · see citing works

REGULATORY MECHANISMS OF CELLULAR RESPIRATION

Barrón, E. S. G., Muntz, J. A., & Gasvoda, B. (1948) · The Journal of General Physiology · doi:10.1085/jgp.32.2.163 · Cited by 39 · see citing works

Viral infection as an NAD+ battlefield

Brenner, C. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00507-3 · Cited by 36 · see citing works

Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans

Nascimento, E. B. M., Moonen, M. P. B., Remie, C. M. E., Gariani, K., Jörgensen, J. A., Schaart, G., Hoeks, J., Auwerx, J. H., Lichtenbelt, W. D. V. M., & Schrauwen, P. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa960 · Cited by 27 · see citing works

Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain Samples by LC/MS/MS Combined with Derivatization Using Nα-(5-Fluoro-2,4-dinitrophenyl)-l-leucinamide (l-FDLA)

Yamamoto, T., Yaku, K., & Nakagawa, T. (2021) · Metabolites · doi:10.3390/metabo11010057 · Cited by 18 · see citing works

Branched-chain amino acids predict incident diabetes in the Brazilian Longitudinal Study of Adult Health – ELSA-Brasil

de Almeida-Pititto, B., Dualib, P. M., Jordão, M. C., Fonseca, M. I. H., Jones, S. R., Blaha, M. J., Toth, P. P., Santos, R. D., Benseñor, I. M., Ferreira, S. R. G., et al. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108747 · Cited by 15 · see citing works

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial

Yi, L., Maier, A. B., Tao, R., Lin, Z., Vaidya, A., Pendse, S., Thasma, S., Andhalkar, N., Avhad, G., & Kumbhar, V. (2022) · GeroScience · doi:10.1007/s11357-022-00705-1 · Cited by 173 · see citing works

NAD metabolism: Role in senescence regulation and aging

Chini, C. C. S., Cordeiro, H. S., Tran, N. L. K., & Chini, E. N. (2023) · Aging Cell · doi:10.1111/acel.13920 · Cited by 138 · see citing works

Regulation of and challenges in targeting NAD+ metabolism

Migaud, M. E., Ziegler, M., & Baur, J. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00752-w · Cited by 134 · see citing works

The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update

Song, Q., Zhou, X., Xu, K., Liu, S., Zhu, X., & Yang, J. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.008 · Cited by 122 · see citing works

Cellular senescence, DNA damage, and neuroinflammation in the aging brain

Zhang, W., Sun, H., Wang, X., Dumont, A. S., & Liu, Q. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.04.003 · Cited by 112 · see citing works

NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health

Alegre, G. F. S., & Pastore, G. M. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00475-y · Cited by 101 · see citing works

The therapeutic perspective of NAD+ precursors in age-related diseases

Iqbal, T., & Nakagawa, T. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149590 · Cited by 65 · see citing works

Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions

Freeberg, K. A., Udovich, C. C., Martens, C. R., Seals, D. R., & Craighead, D. H. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad106 · Cited by 68 · see citing works

Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial

Katayoshi, T., Uehata, S., Nakashima, N., Nakajo, T., Kitajima, N., Kageyama, M., & Tsuji, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-29787-3 · Cited by 54 · see citing works

Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns

Bhasin, S., Seals, D. R., Migaud, M. E., Musi, N., & Baur, J. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad019 · Cited by 47 · see citing works

Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD ⁺ synthesis via enterohepatic circulation

Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr1538 · Cited by 40 · see citing works

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Biţă, A., Scorei, I. R., Ciocîlteu, M. V., Nicolaescu, O. E., Pîrvu, A. S., Bejenaru, L. E., Rău, G., Bejenaru, C., Radu, A., Neamţu, J., et al. (2023) · Molecules · doi:10.3390/molecules28166078 · Cited by 41 · see citing works

Sirtuins in kidney diseases: potential mechanism and therapeutic targets

Jin, Q., Ma, F., Liu, T., Yang, L., Mao, H., Wang, Y., Liang, P., Li, P., & Zhan, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01442-4 · Cited by 39 · see citing works

Nicotinamide Mononucleotide Restores NAD+ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells

Ahmed, M., Riaz, U., Lv, H., Amjad, M., Ahmed, S., Ali, S., Ghani, M. U., Hua, G., & Yang, L. (2024) · Antioxidants · doi:10.3390/antiox14010039 · Cited by 38 · see citing works

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging

Rahman, S. U., Qadeer, A., & Wu, Z. (2024) · Aging and disease · doi:10.14336/ad.2023.0519-1 · Cited by 34 · see citing works

Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study

Morifuji, M., Higashi, S., Ebihara, S., & Nagata, M. (2024) · GeroScience · doi:10.1007/s11357-024-01204-1 · Cited by 32 · see citing works

NAD + Precursors in Human Health and Disease: Current Status and Future Prospects

Yaku, K., & Nakagawa, T. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0354 · Cited by 31 · see citing works

A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder

Szot, J. O., Cuny, H., Martin, E. M. M. A., Sheng, D. Z., Iyer, K. R., Portelli, S., Nguyen, V., Gereis, J. M., Alankarage, D., Chitayat, D. A., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci174824 · Cited by 34 · see citing works

NAD+ precursor supplementation in human ageing: clinical evidence and challenges

Vinten, K. T., Trętowicz, M. M., Coskun, E., van Weeghel, M., Cantó, C., Perez, R. Z., Janssens, G. E., & Houtkooper, R. H. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01387-7 · Cited by 32 · see citing works

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

Imai, S. (2025) · npj Aging · doi:10.1038/s41514-025-00192-6 · Cited by 28 · see citing works

NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies

Loreto, A., Antoniou, C., Merlini, E., Gilley, J., & Coleman, M. P. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.01.004 · Cited by 30 · see citing works

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works

Nicotinamide mononucleotide induces autophagy and ferroptosis via AMPK/mTOR pathway in hepatocellular carcinoma

Sun, Z., Liu, L., Liang, H., & Zhang, L. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23673 · Cited by 27 · see citing works

Advancements in NMN biotherapy and research updates in the field of digestive system diseases

Liao, G., Xie, Y., Peng, H., Li, T., Zou, X., Yue, F., Guo, J., & Rong, L. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05614-9 · Cited by 27 · see citing works

Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications

Benjamin, C., & Crews, R. (2024) · Metabolites · doi:10.3390/metabo14060341 · Cited by 23 · see citing works

NAD metabolism and heart failure: Mechanisms and therapeutic potentials

Walker, M. A., & Tian, R. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.07.008 · Cited by 24 · see citing works

Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration

Kuerec, A. H., Wang, W., Yi, L., Tao, R., Lin, Z., Vaidya, A., Pendse, S., Thasma, S., Andhalkar, N., Avhad, G., et al. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111917 · Cited by 24 · see citing works

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Yamaguchi, S., Irie, J., Mitsuishi, M., Uchino, Y., Nakaya, H., Takemura, R., Inagaki, E., Kosugi, S., Okano, H., Yasui, M., et al. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej23-0431 · Cited by 24 · see citing works

The use of a systems approach to increase NAD+ in human participants

Henderson, J. D., Quigley, S. N. Z., Chachra, S. S., Conlon, N. J., & Ford, D. (2024) · npj Aging · doi:10.1038/s41514-023-00134-0 · Cited by 21 · see citing works

NAD + -A Hub of Energy Metabolism in Heart Failure

Wu, Y., Pei, Z., & Qu, P. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.89370 · Cited by 20 · see citing works

Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects

Yamane, T., Imai, M., Bamba, T., & Uchiyama, S. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.04.031 · Cited by 20 · see citing works

NAD+: An old but promising therapeutic agent for skeletal muscle ageing

Xu, Y., & Xiao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102106 · Cited by 19 · see citing works

The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis

Prokopidis, K., Moriarty, F., Bahat, G., McLean, J., Church, D. D., & Patel, H. P. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13799 · Cited by 18 · see citing works

Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter

Zhang, R., Chen, S., Wang, Z., Ye, L., Yue, J., Li, M., Jiang, X., Peng, H., Guo, Z., Chen, L., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12259 · Cited by 17 · see citing works

Fingerstick blood assay maps real‐world NAD + disparity across gender and age

Wang, P., Chen, M., Hou, Y., Luan, J., Liu, R., Chen, L., Hu, M., & Yu, Q. (2023) · Aging Cell · doi:10.1111/acel.13965 · Cited by 15 · see citing works

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerPreprint

Kane, A. E., Chellappa, K., Schultz, M. B., Arnold, M. W., Li, J., Amorim, J., Diener, C., Zhu, D., Mitchell, S. J., Griffin, P. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.21.599604 · Cited by 16 · see citing works

NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence

Gallagher, C., & Emmanuel, O. O. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103057 · Cited by 17 · see citing works

Stabilization and quantitative measurement of nicotinamide adenine dinucleotide in human whole blood using dried blood spot sampling

Matsuyama, R., Omata, T., Kageyama, M., Nakajima, R., Kanou, M., & Yamana, K. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04469-7 · Cited by 14 · see citing works

Interactions between Intestinal Homeostasis and NAD+ Biology in Regulating Incretin Production and Postprandial Glucose Metabolism

Nagahisa, T., Kosugi, S., & Yamaguchi, S. (2023) · Nutrients · doi:10.3390/nu15061494 · Cited by 14 · see citing works

Absolute quantification of nicotinamide mononucleotide in biological samples by double isotope-mediated liquid chromatography-tandem mass spectrometry (dimeLC-MS/MS)

Unno, J., Mills, K. F., Ogura, T., Nishimura, M., & Imai, S. (2024) · npj Aging · doi:10.1038/s41514-023-00133-1 · Cited by 13 · see citing works

Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges

Wang, E., Wang, Y., Zhang, Z., Jiang, Y., & Zhao, C. (2025) · Biogerontology · doi:10.1007/s10522-025-10270-7 · Cited by 11 · see citing works

In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation of nicotinamide mononucleotide, and its effects on the gut microbiota

Tang, Z., Bao, P., Ling, X., Qiu, Z., Zhang, B., & Hao, T. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113779 · Cited by 11 · see citing works

Advancing antihypertensive drug development

Pu, F., Liu, Y., Ahmed, F. Z., Wang, X., Green, D., & Zhang, H. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70063 · Cited by 14 · see citing works

Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization

Xing, S., Kang, X., Wang, R., Wang, C., Wang, Y., Bao, X., & Zhao, J. (2025) · ACS Synthetic Biology · doi:10.1021/acssynbio.5c00038 · Cited by 9 · see citing works

Dietary Nucleotides Enhance Neurogenesis, Cognitive Capacity, Muscle Function, and Body Composition in Older Adults: A Randomized, Triple-Blind, Controlled Clinical Trial

Gené‐Morales, J., Juesas, Á., Saez-Berlanga, Á., Martin, E. G., Garrigues-Pelufo, L., Sandoval-Camargo, B. S., Martin-Rivera, F., Chulvi‐Medrano, I., Jiménez‐Martínez, P., Alix‐Fages, C., et al. (2025) · Nutrients · doi:10.3390/nu17091431 · Cited by 11 · see citing works

Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials

Chen, F., Zhou, D., Kong, A. P.-S., Yim, N. T., Dai, S., Chen, Y., & Hui, L. L. (2024) · Current Diabetes Reports · doi:10.1007/s11892-024-01557-z · Cited by 8 · see citing works

Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway

Liang, N., Liu, S., Wang, Y., Ying, L., Zhang, K., Li, H., Xiao, L., Hu, Y., & Luo, G. (2025) · Pharmaceuticals · doi:10.3390/ph18040553 · Cited by 8 · see citing works

Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide

Ming, W., Hu, S., Liu, Y., Li, Q.-A.-W., Zhu, Y., & Gu, S.-X. (2023) · Current Organic Chemistry · doi:10.2174/1385272827666230201103848 · Cited by 8 · see citing works

Nicotinamide mononucleotide, a potential future treatment in ocular diseases

Lee, D., Tomita, Y., Shinojima, A., Ban, N., Yamaguchi, S., Nishioka, K., Negishi, K., Yoshino, J., & Kurihara, T. (2023) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-023-06118-w · Cited by 8 · see citing works

Spatial regulation of NMN supplementation on brain lipid metabolism upon subacute and sub-chronic PM exposure in C57BL/6 mice

Jiang, Y., Li, F., Ye, L., Zhang, R., Chen, S., Peng, H., Zhang, H., Li, D., Chen, L., Zeng, X., et al. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00597-3 · Cited by 7 · see citing works

The Role of NAD+ and NAD+-Boosting Therapies in Inflammatory Response by IL-13

Pugel, A. D., Schoenfeld, A. M., Alsaifi, S. Z., Holmes, J. R., & Morrison, B. E. (2024) · Pharmaceuticals · doi:10.3390/ph17020226 · Cited by 7 · see citing works

Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials

Zhang, J., Poon, E. T., & Wong, S. H. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2387324 · Cited by 6 · see citing works

Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases

Manickam, R., Santhana, S., Xuan, W., Bisht, K. S., & Tipparaju, S. M. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2024-0400 · Cited by 6 · see citing works

Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials

Wen, J., Syed, B., Kim, S., Shehabat, M., Ansari, U., Razick, D., Akhtar, M., & Pai, D. (2024) · Cureus · doi:10.7759/cureus.65961 · Cited by 6 · see citing works

Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammationPreprint

Saleh, T. A., Whitson, J. D., Keiser, P., Prasad, P., Jenkins, B. C., Sodeinde, T., Mann, C. N., Rabinovitch, P. S., McReynolds, M. R., & Sweetwyne, M. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.09.588624 · Cited by 6 · see citing works

Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) – possible combination use

Ulpathakumbura, S., Lu, S., Gunarathne, R., Yang, J. Z., Liu, J., Jin, X., Zhou, Q., & Lu, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102992 · Cited by 4 · see citing works

Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development

Cuklanz, K., Stein, A., Chouinard, V., Öngür, D., & Du, F. (2026) · Science Advances · doi:10.1126/sciadv.aea9014 · Cited by 5 · see citing works

An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT

Sun, Y., Han, J., Tran, K., Pham, T., Zhou, Q., & Lu, J. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104191 · Cited by 4 · see citing works

Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases

Krekora, J., Matuszewska-Brycht, O., Wranicz, J. K., Krejca, M., Kaczmarek, K. A., Merks, P., & Dróżdż, J. (2026) · Biomolecules · doi:10.3390/biom16060793 · Cited by 4 · see citing works

Nanoformulations-based functionalized boron nitride nanosheets delivering nicotinamide mononucleotide with enhanced in vitro anti-aging properties

AbouAitah, K., Turk, A., Bu, Y., Sabbagh, F., Lee, M. K., & Kim, B. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106846 · Cited by 4 · see citing works

Coming of age: could obesity-related metabolic complications be treated by targeting senescent cells?

Kasperová, B. J., Cinkajzlová, A., Horváth, L., Svoboda, P., Haluzı́k, M., & Hubáčková, S. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1622107 · Cited by 4 · see citing works

Nicotinamide Mononucleotide in the Context of Myocardiocyte Longevity

Marzoog, B. A. (2023) · Current Aging Science · doi:10.2174/0118746098266041231212105020 · Cited by 4 · see citing works

Changes in glucose metabolism, C-reactive protein, and liver enzymes following intake of NAD + precursor supplementation: a systematic review and meta‐regression analysis

Sohouli, M. H., Tavakoli, S., Reis, M. G., Hekmatdoost, A., & Guimarães, N. S. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00812-0 · Cited by 3 · see citing works

Vitamin B3 derivatives support pancreatic cancer cell survival and chemotherapy resistance

Nakazzi, F., Zarei, M., Lopes, M., Graor, H. J., Beegan, W. C., Gu, E., Rezaei, S., Lund, P. J., & Winter, J. M. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218334 · Cited by 3 · see citing works

Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming

Ying, Y.-Y., Chen, X., Yao, S.-Y., Chen, R.-X., Ying, Y., Qiu, H., Xu, Q.-Q., Li, Z.-Y., Ye, C., Qian, Y.-L., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106200 · Cited by 3 · see citing works

Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang, M., Chen, Y., Jiang, N., Zeng, J., Zhang, J., Wu, C., Liu, Y., Nie, Z., Yang, J., & Han, S. (2026) · Nutrients · doi:10.3390/nu18060890 · Cited by 3 · see citing works

Enhancement of NK Cell Cytotoxic Activity and Immunoregulatory Effects of a Natural Product Supplement Across a Wide Age Span: A 30-Day In Vivo Human Study

Boichuk, S., Galembikova, A. R., & Vollmer, D. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072897 · Cited by 3 · see citing works

Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and OpportunitiesPreprint

Alpay, F. (2025) · ChemRxiv · doi:10.26434/chemrxiv-2025-nl80r · Cited by 4 · see citing works

Oral Supplementation of Nicotinamide Mononucleotide (NMN) Improves Hair Quality and Subjective Perception of Hair Appearance in Middle-Aged Women

Fukumoto, S., Ito, M., Kunitomo, H., Hataoka, T., Chiba, T., Nureki, O., & Fujimoto, T. (2025) · Cosmetics · doi:10.3390/cosmetics12050204 · Cited by 2 · see citing works

Unraveling nicotinamide mononucleotide (NMN): A critical review of health implications, synthesis pathways, and analytical techniques

Li, X., Liu, Y., Luo, Y., Jiang, X., Zhang, H., Zhu, F., Pang, Y., & Chen, D. (2026) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2026.109027 · Cited by 2 · see citing works

Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis

Li, Y., Bao, T., Gao, L., Tian, X., Xue, J., Jin, C., Wang, S., & Wu, X. (2026) · Aging Cell · doi:10.1111/acel.70445 · Cited by 2 · see citing works

Continuous production of nicotinamide mononucleotide by engineered Escherichia coli: effect of dilution rate and glucose feeding

Vo, G. T. T., & Kim, B. S. (2026) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-026-03313-x · Cited by 2 · see citing works

Effects of NAD + precursors on blood pressure, C‐reactive protein concentration and carotid intima‐media thickness: A meta‐analysis of randomized controlled trials

Lei, L., Zhang, X., Lin, J., Liang, Q., Sohouli, M. H., Magalhães, E. I. D. S., Fatahi, S., Yang, L., Xu, W., Wang, X., et al. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14078 · Cited by 2 · see citing works

Enhancing production of nicotinamide mononucleotide by metabolic engineering and flow cytometry screening of Escherichia coli

Yang, L., Wei, Y., Yang, S., Liu, F., Li, Y., Wang, J., & Fan, H. (2025) · Biotechnology Letters · doi:10.1007/s10529-025-03667-4 · Cited by 2 · see citing works

Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene

Isak, V., Azizi, S., Zhou, X. K., Mehta, D., Ding, W., Bulmer, Z., Aivazi, D. S., Dellinger, R. W., & Granstein, R. D. (2024) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12961 · Cited by 1 · see citing works

Effects of Supplementation with NAD + Precursors on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis

Oliveira-Cruz, A., Macedo-Silva, A., Silva-Lima, D., Sanchez-Almeida, J., Coutinho-Cruz, L., Tavares, M. P. S., & Majerowicz, D. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2382-6829 · Cited by 1 · see citing works

Exploring the Therapeutic Potential of Nicotinamide Mononucleotide: A Review of Safety and Efficacy with Emphasis on Diabetes

Gugulski, H., Kozicz, M. A., Rudawski, S., Wójcik, Ł., Zięba, M., Jastrzębska, I., Bado, M., Nowoświat, P., Cuper, P., & Bilecki, K. (2024) · Quality in Sport · doi:10.12775/qs.2024.17.53437 · Cited by 1 · see citing works

β-Nicotinamide Mononucleotide protects against endotoxemia-induced myocardial injury through Sirt5-dependent desuccinylation of succinate dehydrogenase

Tao, H., Dong, Q., Long, Y. L., Liu, L., Qin, S., & Wang, Y. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178562 · Cited by 1 · see citing works

Early-life NAD+ deficiency programs skeletal muscle aging by sustained suppression of hyaluronic acid synthesis beginning in childhood

Karim, M., Yaku, K., Kim, J., Okekawa, A., Wada, T., Uchida, H., MIZUTANI, A., Nguyen, T. C. T., Kawaguchi, Y., Nakagawa, Y., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116912 · Cited by 1 · see citing works

NAD+ and Its Precursors for Health and Longevity

Yi, L. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_5 · Cited by 1 · see citing works

Administration of Nicotinamide Mononucleotide Mitigates the HIV Nef-Induced Metabolic and Pathological Changes in the Heart

Kondrachuk, O., Nakhungu, E., Ogundipe, G., Tailor, N., Ciccone, P., Hong, K., Gadiraju, A., Kimura, Y., Zi, A., Yusuf, S., et al. (2026) · Cells · doi:10.3390/cells15050444 · Cited by 1 · see citing works

Skin Cancer Prevention and Antiaging: Role of Nicotinamide

Moro, F., Panebianco, A., Bartolocci, V., Capone, A., Guardo, A. D., Hyeraci, M., Gemma, G. P. A., Lella, G. D., Colonna, L., Ricci, F., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114918 · Cited by 1 · see citing works

Long-Term NMN Treatment Increases Lifespan and Healthspan in Mice in a Sex Dependent MannerPreprint

Kane, A. E., Chellappa, K., S, M., Arnold, M. W., Li, J., Amorim, J. A., Diener, C., Zhu, D., Mitchell, S. J., Griffin, P. T., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4857461 · Cited by 1 · see citing works

Knockdown of SDC-1 Gene Alleviates the Metabolic Pathway for the Development of MODS

Xie, J., Ma, Y., Huang, Y., Wang, Q., Xu, Y., Zhang, Q., Yang, J., & Yin, W. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00809-9

EFFICACY OF NICOTINAMIDE MONONUCLEOTIDE SUPPLEMENTATION (NMN) IN BLOOD NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) FOR ANTI-AGING IN ADULTS: A SYSTEMATIC REVIEW

Dewi, M. Y. A., Dananjaya, I. M. D., Permadi, A. A. S. S. D., & Sigmahadewi, R. N. (2024) · Journal of Advance Research in Medical & Health Science · doi:10.61841/gyj2gr52

Oral Administration of Nicotinamide Mononucleotide with Bioenhancer BioPerine® Increases the Serum Concentration of Nicotinamide Adenine Dinucleotide in Healthy Human Volunteers: A Pilot, Open-Label, Cross-Over Study

Majeed, A., Majeed, S., Shivakumar, T., Gudimallam, S., Avinash, K. P., Nagaraju, V., & Mundkur, L. (2024) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2024.1510036

Mechanistic basis of NMN and rapamycin in aging biology: Independent and intersecting pathways

Sasidhar, C., Chitra, V., & Kumar, V. N. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102401

Additional file 2 of Changes in glucose metabolism, C-reactive protein, and liver enzymes following intake of NAD + precursor supplementation: a systematic review and meta‐regression analysis

Sohouli, M. H., Tavakoli, S., Reis, M. G., Hekmatdoost, A., & Guimarães, N. S. (2024) · Figshare · doi:10.6084/m9.figshare.26094488

Additional file 3 of Changes in glucose metabolism, C-reactive protein, and liver enzymes following intake of NAD + precursor supplementation: a systematic review and meta‐regression analysis

Sohouli, M. H., Tavakoli, S., Reis, M. G., Hekmatdoost, A., & Guimarães, N. S. (2024) · Figshare · doi:10.6084/m9.figshare.26738268

Additional file 4 of Changes in glucose metabolism, C-reactive protein, and liver enzymes following intake of NAD + precursor supplementation: a systematic review and meta‐regression analysis

Sohouli, M. H., Tavakoli, S., Reis, M. G., Hekmatdoost, A., & Guimarães, N. S. (2024) · Figshare · doi:10.6084/m9.figshare.26738271

Additional file 1 of Changes in glucose metabolism, C-reactive protein, and liver enzymes following intake of NAD + precursor supplementation: a systematic review and meta‐regression analysis

Sohouli, M. H., Tavakoli, S., Reis, M. G., Hekmatdoost, A., & Guimarães, N. S. (2024) · Figshare · doi:10.6084/m9.figshare.26094402

Interplay Between Nicotinamide Mononucleotide and Microbiota: A New Avenue in Metabolic Health

Naaz, T., & Kim, B. S. (2026) · Food Reviews International · doi:10.1080/87559129.2026.2618594

Metabolic reprogramming for reverse aging

Musa, D. A., & Aremu, H. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33159-6.00007-2

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

Nutrition, N. F. A. F. A. (. E. P. O., Turck, D., Bohn, T., Cámara, M., Castenmiller, J. J. M., Henauw, S. D., Jos, A. M., Maciuk, A., Mangelsdorf, I., McNulty, B. A., et al. (2026) · EFSA Journal · doi:10.2903/j.efsa.2026.10007

Preliminary exploration of acute limit toxicity testing for nicotinamide mononucleotide in the neonatal population

Cao, H., Ge, X., Cui, M., Li, B., Ma, L., Gu, J., Xin, R., Li, G., Li, B., & Bi, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1773471

Efficacy of Vitex pseudo‐negundo in a Bovine Mastitis Model Experimentally Induced by Staphylococcus aureus in Rats

KOÇ, H., Fındık, A., Güvenç, T., Batan, N., Fandaklı, S., & Fındık, M. (2026) · Veterinary Medicine and Science · doi:10.1002/vms3.71031

Retinal neurodegeneration as accelerated ocular aging: a review of nutritional and metabolic supplements

Moshtaghion, S. M., Shayan, M., Ramakrishnan, S., Ham, A., Gharehkoshan, A. S., Morley, M. G., Zebardast, N., Diaz-Corrales, F. J. J., Rodríguez-de-la-Rúa-Franch, E., Husain, D., et al. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1912337

Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis

Yang, W., Huang, J., Tang, Z., Chen, C. Y., & Sun, Y. (2026) · Nutrients · doi:10.3390/nu18142251

Metabolic reprogramming orchestrates microglial fate in cerebral ischemia-reperfusion injury: a spatiotemporal immunometabolic perspective

Zhang, M., Li, H., & Zhang, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1831494

Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging

Sun, Y., Li, B., & Qian, Z. (2026) · Metabolites · doi:10.3390/metabo16080597

Sustained NAD⁺ augmentation by high-dose nicotinamide mononucleotide supplementation in older adults: a 24-week randomized, double-blind, placebo-controlled trial

Igarashi, M., Naruse, K., Takaoka, Y., Miura, M., Kashiwabara, K., Sawada, M., Sekine, R., Kubota, N., Suzuki, M., Yoshida, Y., et al. (2026) · npj Aging · doi:10.1038/s41514-026-00482-7

NAD+ precursor role in modulating NAD level in human beings and their therapeutic effects

(2024) · doi:10.48047/afjbs.6.15.2024.1827-1843

Intravenous Uptake of NMN is Safely Metabolize and Increases NAD+ Levels in Healthy SubjectsPreprint

Kimura, S., Ichikawa, M., Sugawara, S., Katagiri, T., Hirasawa, Y., Ishikawa, T., Matsunaga, W., & Gotoh, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1298321/v1 · Cited by 1 · see citing works

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Igarashi, M., Nakagawa-Nagahama, Y., Miura, M., Kashiwabara, K., Yaku, K., Sawada, M., Sekine, R., Fukamizu, Y., Sato, T., Sakurai, T., et al. (2022) · npj Aging · doi:10.1038/s41514-022-00084-z · Cited by 125 · see citing works

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Yamaguchi, S., Irie, J., Mitsuishi, M., Uchino, Y., Nakaya, H., Takemura, R., Inagaki, E., Kosugi, S., Okano, H., Yasui, M., et al. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej23-0431 · Cited by 24 · see citing works