Pietzner, Maik

Mapping the proteo-genomic convergence of human diseases

Pietzner, M., Wheeler, E., Carrasco-Zanini, J., Cortes, A., Koprulu, M., Wörheide, M. A., Oerton, E., Cook, J., Stewart, I. D., Kerrison, N. D., et al. (2021) · Science

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 657

Metabolomic profiles predict individual multidisease outcomes

Buergel, T., Steinfeldt, J., Ruyoga, G., Pietzner, M., Bizzarri, D., Vojinovic, D., Upmeier zu Belzen, J., Loock, L., Kittner, P., Christmann, L., et al. (2022) · Nature Medicine

Metabolomics and Mass Spectrometry StudiesHealth, Environment, Cognitive Aging

Cited by 406

Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

Pietzner, M., Wheeler, E., Carrasco-Zanini, J., Kerrison, N. D., Oerton, E., Koprulu, M., Luan, J., Hingorani, A. D., Williams, S. A., Wareham, N. J., et al. (2021) · Nature Communications

Genetic Associations and EpidemiologyAdvanced Biosensing Techniques and Applications

Cited by 234

Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., et al. (2018) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchMetabolomics and Mass Spectrometry Studies

Cited by 197

Measuring Biological Age via Metabonomics: The Metabolic Age Score

Hertel, J., Friedrich, N., Wittfeld, K., Pietzner, M., Budde, K., Van der Auwera, S., Lohmann, T., Teumer, A., Völzke, H., Nauck, M., et al. (2016) · Journal of Proteome Research

Metabolomics and Mass Spectrometry StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 181

Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study

Ameling, S., Kacprowski, T., Chilukoti, R. K., Malsch, C., Liebscher, V., Suhre, K., Pietzner, M., Friedrich, N., Homuth, G., Hammer, E., et al. (2015) · BMC Medical Genomics

MicroRNA in disease regulationExtracellular vesicles in disease

Cited by 181

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior

Cornelis, M. C., Kacprowski, T., Menni, C., Gustafsson, S., Pivin, E., Adamski, J., Artati, A., Eap, C. B., Ehret, G., Friedrich, N., et al. (2016) · Human Molecular Genetics

Coffee research and impactsGenetic Associations and Epidemiology

Cited by 175

Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease

Hertel, J., Harms, A. C., Heinken, A., Baldini, F., Thinnes, C. C., Glaab, E., Vasco, D. A., Pietzner, M., Stewart, I. D., Wareham, N. J., et al. (2019) · Cell Reports

Gut microbiota and healthParkinson's Disease Mechanisms and Treatments

Cited by 162

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.

Sterenborg, R. B. T. M., Steinbrenner, I., Li, Y., Bujnis, M. N., Naito, T., Marouli, E., Galesloot, T. E., Babajide, O., Andreasen, L., Astrup, A., et al. (2024) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

Cited by 79

Effects of sex hormone treatment on the metabolic syndrome in transgender individuals: focus on metabolic cytokines

Auer, M. K., Ebert, T., Pietzner, M., Defreyne, J., Fuss, J., Stalla, G. K., & T’Sjoen, G. (2018) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesHormonal and reproductive studies

Cited by 75

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., Friedrich, N., van der Harst, P., Joshi, P. K., Karhunen, V., et al. (2021) · Journal of Human Genetics

Genetic Associations and EpidemiologyStress Responses and Cortisol

Cited by 74

Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases

Cai, N., Gomez-Duran, A., Yonova-Doing, E., Kundu, K., Burgess, A. I., Golder, Z. J., Calabrese, C., Bonder, M. J., Camacho, M., Lawson, R. A., et al. (2021) · Nature Medicine

Mitochondrial Function and PathologyGenetic Associations and Epidemiology

Cited by 73

Proteogenomic links to human metabolic diseases

Koprulu, M., Carrasco-Zanini, J., Wheeler, E., Lockhart, S., Kerrison, N. D., Wareham, N. J., Pietzner, M., & Langenberg, C. (2023) · Nature Metabolism

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 57

Mapping the serum proteome to neurological diseases using whole genome sequencing

Png, G., Barysenka, A., Repetto, L., Navarro, P., Shen, X., Pietzner, M., Wheeler, E., Wareham, N. J., Langenberg, C., Tsafantakis, E., et al. (2021) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 55

Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study

Carrasco-Zanini, J., Pietzner, M., Koprulu, M., Wheeler, E., Kerrison, N. D., Wareham, N. J., & Langenberg, C. (2024) · The Lancet Digital Health

Genetic Associations and EpidemiologyHealth, Environment, Cognitive Aging

Cited by 46

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization

Zheng, J., Wheeler, E., Pietzner, M., Andlauer, T. F. M., Yau, M. S., Hartley, A. E., Brumpton, B. M., Rasheed, H., Kemp, J. P., Frysz, M., et al. (2023) · Arthritis & Rheumatology

Bone health and osteoporosis researchGenetic Associations and Epidemiology

Cited by 44

Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model

Pietzner, M., Engelmann, B., Kacprowski, T., Golchert, J., Dirk, A.-L., Hammer, E., Iwen, K. A., Nauck, M., Wallaschofski, H., Führer, D., et al. (2017) · BMC Medicine

Thyroid Disorders and TreatmentsMetabolomics and Mass Spectrometry Studies

Cited by 40

Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers

Smith-Byrne, K., Hedman, Å., Dimitriou, M., Desai, T., Sokolov, A. V., Schioth, H. B., Koprulu, M., Pietzner, M., Langenberg, C., Atkins, J., et al. (2024) · Nature Communications

Genetic Associations and EpidemiologyCancer Genomics and Diagnostics

Cited by 33

Translating pharmacological findings from hypothyroid rodents to euthyroid humans: is there a functional role of endogenous 3,5-T2?

Pietzner, M., Lehmphul, I., Friedrich, N., Schurmann, C., Ittermann, T., Dörr, M., Nauck, M., Laqua, R., Völker, U., Brabant, G., et al. (2015) · Thyroid

Thyroid Disorders and TreatmentsFatty Acid Research and Health

Cited by 31

3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

Köhrle, J., Lehmphul, I., Pietzner, M., Renko, K., Rijntjes, E., Richards, K., Anselmo, J., Danielsen, M., & Jonklaas, J. (2020) · Frontiers in Endocrinology

Thyroid Disorders and TreatmentsHormonal and reproductive studies

Cited by 23

Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

Friedrich, N., Pietzner, M., Cannet, C., Thuesen, B. H., Hansen, T., Wallaschofski, H., Grarup, N., Skaaby, T., Budde, K., Pedersen, O., et al. (2017) · PLOS ONE

Thyroid Disorders and TreatmentsMetabolomics and Mass Spectrometry Studies

Cited by 23

Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases

Li, Y., Cheng, Y., Consolato, F., Schiano, G., Chong, M. R., Pietzner, M., Nguyen, N. Q. H., Scherer, N., Biggs, M. L., Kleber, M. E., et al. (2022) · JCI Insight

Genetic Associations and EpidemiologyRenal Diseases and Glomerulopathies

Cited by 22

A Thyroid Hormone-Independent Molecular Fingerprint of 3,5-Diiodothyronine Suggests a Strong Relationship with Coffee Metabolism in Humans

Pietzner, M., Köhrle, J., Lehmphul, I., Budde, K., Kastenmüller, G., Brabant, G., Völzke, H., Artati, A., Adamski, J., Völker, U., et al. (2019) · Thyroid®

Thyroid Disorders and TreatmentsMetabolomics and Mass Spectrometry Studies

Cited by 13

Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms

Pietzner, M., Williamson, A., Hunt, K. A., Koprulu, M., Kohleick, L., Demircan, K., Genes & Health Research Team, Finer, S., Zanini, J. C., van Heel, D. A., et al. (2025) · medRxiv

Genetic Associations and EpidemiologyAdvanced Proteomics Techniques and Applications

Cited by 4