Gromada, Jesper

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation

Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,125

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 922

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

Dewey, F. E., Gusarova, V., Dunbar, R. L., O’Dushlaine, C., Schurmann, C., Gottesman, O., McCarthy, S., Van Hout, C. V., Bruse, S., Dansky, H. M., et al. (2017) · New England Journal of Medicine

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 885

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., et al. (2018) · New England Journal of Medicine

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 827

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans

Holst, J. J., & Gromada, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 611

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 497

Endoplasmic reticulum stress and pancreatic β-cell death

Fonseca, S. G., Gromada, J., & Urano, F. (2011) · Trends in Endocrinology & Metabolism

Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetes

Cited by 384

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

Smagris, E., BasuRay, S., Li, J., Huang, Y., Lai, K. V., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Hepatology

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 379

ANGPTL3 inhibition in homozygous familial hypercholesterolemia

Gaudet, D., Gipe, D. A., Pordy, R., Ahmad, Z., Cuchel, M., Shah, P. K., Chyu, K.-Y., Sasiela, W. J., Chan, K.-C., Brisson, D., et al. (2017) · New England Journal of Medicine

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 323

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Wang, Y., Quagliarini, F., Gusarova, V., Gromada, J., Valenzuela, D. M., Cohen, J. C., & Hobbs, H. H. (2013) · Proceedings of the National Academy of Sciences

Lipid metabolism and disordersLipid metabolism and biosynthesis

Cited by 317

SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells

Eliasson, L., Ma, X., Renström, E., Barg, S., Berggren, P.-O., Galvanovskis, J., Gromada, J., Jing, X., Lundquist, I., Salehi, A., et al. (2003) · The Journal of General Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 257

Regulation of glucagon release in mouse α‐cells by KATP channels and inactivation of TTX‐sensitive Na+ channels

Göpel, S. O., Kanno, T., Barg, S., Weng, X. ‐., Gromada, J., & Rorsman, P. (2000) · The Journal of Physiology

Pancreatic function and diabetesIon channel regulation and function

Cited by 229

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

Gusarova, V., Alexa, C. A., Wang, Y., Rafique, A., Kim, J. H., Buckler, D., Mintah, I. J., Shihanian, L. M., Cohen, J. C., Hobbs, H. H., et al. (2015) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 210

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., et al. (2020) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 208

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

Gusarova, V., Alexa, C. A., Na, E., Stevis, P. E., Xin, Y., Bonner-Weir, S., Cohen, J. C., Hobbs, H. H., Murphy, A. J., Yancopoulos, G. D., et al. (2014) · Cell

Pancreatic function and diabetesLipid metabolism and disorders

Cited by 202

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Xin, Y., Dominguez Gutierrez, G., Okamoto, H., Kim, J., Lee, A.-H., Adler, C., Ni, M., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Diabetes

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 191

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

Wang, Y., Gusarova, V., Banfi, S., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Journal of Lipid Research

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 189

Activin A more prominently regulates muscle mass in primates than does GDF8

Latres, E., Mastaitis, J., Fury, W., Miloscio, L., Trejos, J., Pangilinan, J., Okamoto, H., Cavino, K., Na, E., Papatheodorou, A., et al. (2017) · Nature Communications

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 185

A TP-Sensitive K+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1−/− Mouse α-Cells

Gromada, J., Ma, X., Høy, M., Bokvist, K., Salehi, A., Berggren, P.-O., & Rorsman, P. (2004) · Diabetes

Pancreatic function and diabetesIon channel regulation and function

Cited by 164

Glucose Stimulates Glucagon Release in Single Rat α-Cells by Mechanisms that Mirror the Stimulus-Secretion Coupling in β-Cells

Olsen, H. L., Theander, S., Bokvist, K., Buschard, K., Wollheim, C. B., & Gromada, J. (2005) · Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 156

The α-cell in diabetes mellitus

Gromada, J., Chabosseau, P., & Rutter, G. A. (2018) · Nature Reviews Endocrinology

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 143

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Latres, E., Pangilinan, J., Miloscio, L., Bauerlein, R., Na, E., Potocky, T. B., Huang, Y., Eckersdorff, M., Rafique, A., Mastaitis, J., et al. (2015) · Skeletal Muscle

Muscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

Cited by 143

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

Bokvist, K., Olsen, H. L., Høy, M., Gotfredsen, C. F., Holmes, W. F., Buschard, K., Rorsman, P., & Gromada, J. (1999) · Pflügers Archiv

Ion channel regulation and functionPancreatic function and diabetes

Cited by 132

Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic β-cells

Braun, M., Wendt, A., Birnir, B., Broman, J., Eliasson, L., Galvanovskis, J., Gromada, J., Mulder, H., & Rorsman, P. (2004) · The Journal of General Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 130