Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis
Open accessAbstract
Significance: Here we show that ANGPTL8 plays a major role in the trafficking of triglycerides to peripheral tissues in response to food intake in mice. Circulating triglycerides are predominantly delivered to skeletal muscle and heart during fasting and are partitioned to adipose tissue upon refeeding. The postprandial increase in triglyceride delivery to adipose tissue is abolished in mice lacking ANGPTL8; consequently, the mice fail to replenish triglyceride stores in adipose tissue. Despite major alterations in triglyceride metabolism, no defects in glucose metabolism were detected in Angptl8 −/− mice. The finding that plasma triglyceride levels are lower in Angptl8 +/− mice suggests that even partial inhibition of ANGPTL8 may provide therapeutic benefit for treatment of dyslipidemia.
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Angptl8 knockout mice do not show impairments in glucose homeostasis or β-cell expansion.
“Subsequent studies, however, did not reveal impairments in glucose homeostasis179 or β-cell expansion in Angptl8 knockout mice.180”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [179]
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- Authors
- Wang, Y., Quagliarini, F., Gusarova, V., Gromada, J., Valenzuela, D. M., Cohen, J. C., & Hobbs, H. H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Departments of bMolecular Genetics and
- Regeneron (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-09-16
- Volume
- 110
- Issue
- 40
- Pages
- 16109-16114
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3791734
- OpenAlex
- W2141428393
- Cited by
- 317
- References
- 37
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 15 · 2023: 22 · 2022: 14 · 2021: 31 · 2020: 28 · 2019: 23 · 2018: 27 · 2017: 33 · 2016: 45 · 2015: 36 · 2014: 24 · 2013: 2
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001105, UL1TR000451)
- National Heart, Lung, and Blood Institute (P01HL020948, RL1HL092550)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- ANGPTL8, betatrophin, angiopoietin-like proteins, triglyceride metabolism, glucose homeostasis, lipoprotein lipase, very low density lipoprotein secretion, fasting and refeeding, hypertriglyceridemia, insulin secretion
- MeSH terms
- Angiopoietin-like Proteins, Angiopoietin-Like Protein 8, Adipose Tissue, Animals, Biological Transport, Calorimetry, Indirect, Glucose, Homeostasis, Male, Mice, Inbred C57BL, Triglycerides, Immunoblotting, Cholesterol, VLDL, Sequence Analysis, DNA, Mice, Knockout, Peptide Hormones, Dyslipidemias, Mice, Real-Time Polymerase Chain Reaction
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