The α-cell in diabetes mellitus

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011 · see citing works

A genome-wide association study identifies novel risk loci for type 2 diabetes

Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993 · see citing works

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

Baron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.08.011 · Cited by 1,508 · see citing works

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415 · see citing works

A Single-Cell Transcriptome Atlas of the Human Pancreas

Muraro, M. J., Dharmadhikari, G., Grün, D., Gröen, N., Dielen, T., Jansen, E., van Gurp, L., Engelse, M. A., Carlotti, F., de Koning, E. J. P., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.09.002 · Cited by 1,288 · see citing works

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136 · see citing works

The genetic architecture of type 2 diabetes

Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., Ma, C., Fontanillas, P., Moutsianas, L., McCarthy, D. J., et al. (2016) · Nature · doi:10.1038/nature18642 · Cited by 1,051 · see citing works

The interaction of hepatic lipid and glucose metabolism in liver diseases

Bechmann, L. P., Hannivoort, R. A., Gerken, G., Hotamışlıgil, G. S., Trauner, M., & Canbay, A. E. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.025 · Cited by 992 · see citing works

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works

Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes.

Cryer, P. (2002) · Diabetologia · doi:10.1007/s00125-002-0822-9 · Cited by 794 · see citing works

Pancreatic β‐cell mass in European subjects with type 2 diabetes

Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756 · see citing works

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients

Sakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., & Yagihashi, S. (2002) · Diabetologia · doi:10.1007/s125-002-8248-z · Cited by 699 · see citing works

Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect

Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688 · see citing works

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

Xin, Y., Kim, J., Okamoto, H., Ni, M., Wei, Y., Adler, C., Murphy, A. J., Yancopoulos, G. D., Lin, C., & Gromada, J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.018 · Cited by 677 · see citing works

Abnormal Alpha-Cell Function in Diabetes: Response to Carbohydrate and Protein Ingestion

Müller, W. A., Faloona, G. R., Aguilar-Parada, E., & Unger, R. H. (1970) · New England Journal of Medicine · doi:10.1056/nejm197007162830301 · Cited by 626 · see citing works

α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains

Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 574 · see citing works

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

Cinti, F., Bouchi, R., Kim-Muller, J. Y., Ohmura, Y., Sandoval, P. R., Masini, M., Marselli, L., Suleiman, M., Ratner, L. E., Marchetti, P., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2860 · Cited by 552 · see citing works

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

Clark, A., Wells, C. A., BULEY, I. D., Cruickshank, J. K., Vanhegan, R. I., Matthews, D. R., Cooper, G. J. S., Holman, R. R., & Turner, R. C. (1988) · PubMed · Cited by 518 · see citing works

Residual insulin production and pancreatic β-cell turnover after 50 years of diabetes: Joslin Medalist Study

Keenan, H. A., Sun, J. K., Levine, J., Doria, A., Aiello, L. P., Eisenbarth, G., Bonner-Weir, S., & King, G. L. (2010) · Diabetes · doi:10.2337/db10-0676 · Cited by 500 · see citing works

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498 · see citing works

Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

Del Guerra, S., Lupi, R., Marselli, L., Masini, M., Bugliani, M., Sbrana, S., Torri, S., Pollera, M., Boggi, U., Mosca, F., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.727 · Cited by 466 · see citing works

Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels

Rorsman, P., Berggren, P., Bokvist, K. B., Ericson, H., Möhler, H., Östenson, C., & Smith, P. A. (1989) · Nature · doi:10.1038/341233a0 · Cited by 460 · see citing works

Beta cell hubs dictate pancreatic islet responses to glucose

Johnston, N. R., Mitchell, R. K., Haythorne, E., Pessoa, M. P., Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.020 · Cited by 454 · see citing works

Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

Sekine, N., Cirulli, V., Regazzi, R., Brown, L. J., Giné, E., Tamarit‐Rodriguez, J., Girotti, M., Marie, S., MacDonald, M. J., & Wollheim, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37629-9 · Cited by 446 · see citing works

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

Morán, I., Akerman, İ., van de Bunt, M., Xie, R., Benazra, M., Nammo, T., Arnes, L., Nakić, N., García-Hurtado, J., Rodríguez‐Seguí, S. A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.010 · Cited by 442 · see citing works

Abnormal Glucose Counterregulation in Insulin-dependent Diabetes Mellitus: Interaction of Anti-Insulin Antibodies and Impaired Glucagon and Epinephrine Secretion

Bolli, G., Feo, P. D., Compagnucci, P., Cartechini, M. G., Angeletti, G., Santeusanio, F., Brunetti, P., & Gerich, J. E. (1983) · Diabetes · doi:10.2337/diab.32.2.134 · Cited by 433 · see citing works

The New Biology and Pharmacology of Glucagon

Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419 · see citing works

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

Gao, T., McKenna, B. D., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N. M., Zhang, T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.002 · Cited by 414 · see citing works

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Bramswig, N. C., Everett, L. J., Schug, J., Dorrell, C., Liu, C., Luo, Y., Streeter, P. R., Naji, A., Grompe, M., & Kaestner, K. H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66514 · Cited by 402 · see citing works

Cellular composition of the human diabetic pancreas

Rahier, J., Goebbels, R. M., & Henquin, J. C. (1983) · Diabetologia · doi:10.1007/bf00251826 · Cited by 395 · see citing works

Islet β-cell secretion determines glucagon release from neighbouring α-cells

Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P. L., & Wollheim, C. B. (2003) · Nature Cell Biology · doi:10.1038/ncb951 · Cited by 380 · see citing works

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants

Nicolson, T. J., Bellomo, E. A., Wijesekara, N., Loder, M. K., Baldwin, J. M., Gyulkhandanyan, A. V., Koshkin, V., Tarasov, A. I., Carzaniga, R., Kronenberger, K., et al. (2009) · Diabetes · doi:10.2337/db09-0551 · Cited by 372 · see citing works

ORIGIN AND DISTRIBUTION OF THE HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR OF THE PANCREAS

Sutherland, E. W., & de Duve, C. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57183-0 · Cited by 355 · see citing works

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

DiGruccio, M. R., Mawla, A. M., Donaldson, C. J., Noguchi, G. M., Vaughan, J., Cowing-Zitron, C., van der Meulen, T., & Huising, M. O. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.007 · Cited by 353 · see citing works

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.

Rutter, G., Pullen, T., Hodson, D., & Martinez-Sánchez, A. (2015) · Biochemical Journal · doi:10.1042/bj20141384 · Cited by 344 · see citing works

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

Blodgett, D. M., Nowosielska, A., Afik, S., Pechhold, S., Cura, A. J., Kennedy, N. J., Kim, S., Kucukural, A., Davis, R. J., Kent, S. C., et al. (2015) · Diabetes · doi:10.2337/db15-0039 · Cited by 330 · see citing works

Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis

Ben-Othman, N., Vieira, A., Courtney, M., Record, F., Gjernes, E., Avolio, F., Hadzic, B., Druelle, N., Napolitano, T., Navarro-Sanz, S., et al. (2017) · Cell · doi:10.1016/j.cell.2016.11.002 · Cited by 322 · see citing works

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

Kawamori, D., Kurpad, A. J., Hu, J., Liew, C. W., Shih, J. L., Ford, E. L., Herrera, P. L., Polonsky, K. S., McGuinness, O. P., & Kulkarni, R. N. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.007 · Cited by 316 · see citing works

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Rodriguez‐Diaz, R., Dando, R., Jacques-Silva, M. C., Fachado, A., Molina, J., Abdulreda, M. H., Ricordi, C., Roper, S. D., Berggren, P., & Caicedo, A. (2011) · Nature Medicine · doi:10.1038/nm.2371 · Cited by 305 · see citing works

Insulin within islets is a physiologic glucagon release inhibitor

Maruyama, H., Hisatomi, A., Orci, L., Grodsky, G. M., & Unger, R. H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111658 · Cited by 303 · see citing works

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302 · see citing works

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

Ackermann, A. M., Wang, Z. P., Schug, J., Naji, A., & Kaestner, K. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.01.002 · Cited by 299 · see citing works

The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells

Oram, R. A., Jones, A. G., Besser, R. E. J., Knight, B. A., Shields, B. M., Brown, R. J., Hattersley, A. T., & McDonald, T. J. (2014) · Diabetologia · doi:10.1007/s00125-013-3067-x · Cited by 298 · see citing works

Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic Humans

Stefan, Y., Orci, L., MALAISSE-LAGAE, F., Perrelet, A., Patel, Y., & Unger, R. H. (1982) · Diabetes · doi:10.2337/diab.31.8.694 · Cited by 272 · see citing works

Glucagon: molecular physiology, clinical and therapeutic implications

Lefèbvre, P. J., & Unger, R. H. (1972) · Medical Entomology and Zoology · Cited by 268 · see citing works

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

Ravier, M. A., & Rutter, G. A. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1789 · Cited by 264 · see citing works

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

Marchetti, P., Lupi, R., Bugliani, M., Kirkpatrick, C. L., Sebastiani, G., Grieco, F. A., Guerra, S. D., D’Aleo, V., Piro, S., Marselli, L., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2716-9 · Cited by 259 · see citing works

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

Courtney, M. L., Gjernes, E., Druelle, N., Ravaud, C., Vieira, A., Ben-Othman, N., Pfeifer, A., Avolio, F., Leuckx, G., Lacas‐Gervais, S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003934 · Cited by 258 · see citing works

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

Kahn, S. E., Zraika, S., Utzschneider, K. M., & Hull, R. L. (2009) · Diabetologia · doi:10.1007/s00125-009-1321-z · Cited by 255 · see citing works

Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes.

Orci, L., Baetens, D., Rufener, C., AMHERDT, M., Ravazzola, M., Studer, P., MALAISSE-LAGAE, F., & Unger, R. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1338 · Cited by 254 · see citing works

Single‐cell transcriptomes reveal characteristic features of human pancreatic islet cell types

Li, J., Klughammer, J., Farlik, M., Penz, T., Spittler, A., Barbieux, C., Berishvili, E., Bock, C., & Kubicek, S. (2015) · EMBO Reports · doi:10.15252/embr.201540946 · Cited by 254 · see citing works

Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells

Salomon, D., & Meda, P. (1986) · Experimental Cell Research · doi:10.1016/0014-4827(86)90354-x · Cited by 252 · see citing works

The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice

Chambers, A. P., Sorrell, J. E., Haller, A. M., Roelofs, K. J., Hutch, C. R., Kim, K., Gutiérrez‐Aguilar, R., Li, B., Drucker, D. J., D’Alessio, D. A., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.008 · Cited by 242 · see citing works

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4033-1 · Cited by 223 · see citing works

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.002 · Cited by 222 · see citing works

Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

Færch, K., Vistisen, D., Pacini, G., Torekov, S. S., Johansen, N. B., Witte, D. R., Jonsson, A., Pedersen, O., Hansen, T., Lauritzen, T., et al. (2016) · Diabetes · doi:10.2337/db16-0240 · Cited by 217 · see citing works

Heterogeneity in Pancreatic β-cell Population

PIPELEERS, D. G. (1992) · Diabetes · doi:10.2337/diab.41.7.777 · Cited by 214 · see citing works

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx

Chakravarthy, H., Gu, X., Enge, M., Dai, X.-Q., Wang, Y., Damond, N., Downie, C. G., Liu, K., Wang, J., Xing, Y., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.009 · Cited by 212 · see citing works

Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.

Taborsky, G. J., Åhrén, B., & Havel, P. J. (1998) · Diabetes · doi:10.2337/diabetes.47.7.995 · Cited by 210 · see citing works

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W.-H., Bugliani, M., Marchetti, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68459 · Cited by 210 · see citing works

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet β-Cells

Xavier, G. D. S., Loder, M. K., McDonald, A., Tarasov, A. I., Carzaniga, R., Kronenberger, K., Barg, S., & Rutter, G. A. (2009) · Diabetes · doi:10.2337/db08-1187 · Cited by 207 · see citing works

Liver-Specific Disruption of the Murine Glucagon Receptor Produces α-Cell Hyperplasia

Longuet, C., Robledo, A. M., Dean, E. D., Dai, C., Ali, S., McGuinness, I., de Chavez, V., Vuguin, P. M., Charron, M. J., Powers, A. C., et al. (2012) · Diabetes · doi:10.2337/db11-1605 · Cited by 207 · see citing works

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

Avrahami, D., Li, C., Zhang, J., Schug, J., Avrahami, R., Rao, S., Stadler, M. B., Burger, L., Schübeler, D., Glaser, B., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.025 · Cited by 207 · see citing works

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation

Dean, E. D., Li, M., Prasad, N., Wisniewski, S., Deylen, A. V., Spaeth, J. M., Maddison, L. A., Botros, A., Sedgeman, L. R., Bozadjieva-Kramer, N., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.011 · Cited by 207 · see citing works

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

Xiao, X., Guo, P., Shiota, C., Zhang, T., Coudriet, G. M., Fischbach, S., Prasadan, K. L., Fusco, J. C., Ramachandran, S., Witkowski, P., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2017.11.020 · Cited by 197 · see citing works

Homologous and heterologous asynchronicity between identified α‐, β‐ and δ‐cells within intact islets of Langerhans in the mouse

Nadal, Á., Quesada, I., & Soria, B. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0085z.x · Cited by 196 · see citing works

Pancreatic alpha cell mass in European subjects with type 2 diabetes

Henquin, J., & Rahier, J. (2011) · Diabetologia · doi:10.1007/s00125-011-2118-4 · Cited by 195 · see citing works

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogrammingPreprint

Papizan, J. B., Singer, R. A., Tschen, S.-I., Dhawan, S., Friel, J. M., Hipkens, S. B., Magnuson, M. A., Bhushan, A., & Sussel, L. (2011) · Genes & Development · doi:10.1101/gad.173039.111 · Cited by 193 · see citing works

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Xin, Y., Dominguez Gutierrez, G., Okamoto, H., Kim, J., Lee, A.-H., Adler, C., Ni, M., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Diabetes · doi:10.2337/db18-0365 · Cited by 191 · see citing works

Differences in Glucose Transporter Gene Expression between Rat Pancreatic α- and β-Cells Are Correlated to Differences in Glucose Transport but Not in Glucose Utilization

Heimberg, H., De Vos, A., Pipeleers, D., Thorens, B., & Schuit, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8971 · Cited by 188 · see citing works

Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver–α-Cell Axis

Holst, J. J., Wewer Albrechtsen, N. J., Pedersen, J., & Knop, F. K. (2017) · Diabetes · doi:10.2337/db16-0994 · Cited by 187 · see citing works

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

Solloway, M. J., Madjidi, A., Gu, C., Eastham-Anderson, J., Clarke, H. J., Kljavin, N. M., Zavala‐Solorio, J., Kates, L., Friedman, B. A., Brauer, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.034 · Cited by 186 · see citing works

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, J., Okamoto, H., Huang, Z., Guillermo Anguiano, L., Chen, S., Liu, Q., Cavino, K., Xin, Y., Na, E., Hamid, R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.006 · Cited by 183 · see citing works

Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

Zhao, C., Wilson, M. C., Schuit, F. C., Halestrap, A. P., & Rutter, G. A. (2001) · Diabetes · doi:10.2337/diabetes.50.2.361 · Cited by 171 · see citing works

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

Pisania, A., Weir, G. C., O’Neil, J. J., Omer, A., Tchipashvili, V., Lei, J., Colton, C. K., & Bonner‐Weir, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.124 · Cited by 169 · see citing works

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells

Xin, Y., Kim, J., Ni, M., Wei, Y. Z., Okamoto, H., Lee, J., Adler, C., Cavino, K., Murphy, A. J., Yancopoulos, G. D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602306113 · Cited by 168 · see citing works

DNA methylation directs functional maturation of pancreatic β cells

Dhawan, S., Tschen, S.-I., Zeng, C., Guo, T., Hebrok, M., Matveyenko, A. V., & Bhushan, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79956 · Cited by 164 · see citing works

The cytological characters of the areas of langerhans

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Regeneration of β cells from cell phenotype conversion among the pancreatic endocrine cells

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Pancreatic Hormones

MEYTS, P. D., & Lefèbvre, P. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00017-1 · Cited by 3 · see citing works

GPR41 and GPR43 modulate rodent pancreatic α-cell function and growth

Sánchez-Roncero, A., Fernández‐Marcelo, T., Perez-Serna, A. A., Martín, M. Á., Alberquilla, O., Sánchez‐Domínguez, R., Segovia, J. C., Escrivá, F., Gálvez, B. G., Álvarez, C., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123913 · Cited by 2 · see citing works

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells

Huang, Y., Rupnik, M. S., & Rutter, G. A. (2026) · Communications Biology · doi:10.1038/s42003-026-10163-6 · Cited by 2 · see citing works

Alpha cell function in type 1 diabetes

Hughes, D. S., & Narendran, P. (2014) · The British Journal of Diabetes · doi:10.15277/bjdvd.2014.014 · Cited by 23 · see citing works

Dual role for glucagon-producing α-cells in diabetes: contribution to disease progression and to restoration of insulin production

Damond, N. (2015) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:79448

Evolving function and potential of pancreatic alpha cells

Stanojevic, V., & Habener, J. F. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.10.002 · Cited by 48 · see citing works

Current ideas about the a-cells population and their role in the pathogenesis of diabetes mellitus

Plushkina, A. S., & Калигин, М. С. (2015) · Genes and Cells · doi:10.23868/gc120472 · Cited by 1 · see citing works

The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes

Gilon, P. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.004 · Cited by 90 · see citing works