AMPK signalling in health and disease
Open accessAbstract
In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.
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AMPK plays a central role in macrophage metabolic reprogramming.
“AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, plays a central role in this process (33–36).”
From Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages (2026) · cites this paper as [36]
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
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Metformin activates AMPK through the lysosomal pathway
Zhang, C.-S., Li, M., Ma, T., Zong, Y., Cui, J., Feng, J.-W., Wu, Y.-Q., Lin, S.-Y., & Lin, S.-C. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.003 · Cited by 280 · see citing works
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The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
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Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells
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Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
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Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase
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- Authors
- Carling, D.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Carling, David
- ORCID
- Carling, David
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 45
- Pages
- 31-37
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2589445559
- Cited by
- 797
- References
- 6
- Citations by year
- 2026: 60 · 2025: 90 · 2024: 107 · 2023: 102 · 2022: 137 · 2021: 102 · 2020: 83 · 2019: 49 · 2018: 38 · 2017: 29
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- Medical Research Council
- BBSRC/CASE PhD studentship award in collaboration with AstraZeneca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- AMPK, AMPK signaling, cellular energy homeostasis, metabolic disorders, type 2 diabetes, cancer, therapeutic target
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Humans, Metabolic Diseases, Neoplasms, Signal Transduction, AMP-Activated Protein Kinases
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