Rubinsztein, David C.

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

Rubinsztein, D. C., Bento, C. F., & Deretic, V. (2015) · Journal of Experimental Medicine

Autophagy in Disease and TherapyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 202

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP), Jones, L., Lambert, J., Wang, L., Choi, S., Harold, D., Vedernikov, A., Escott‐Price, V., Stone, T., Richards, A., et al. (2015) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 199

Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity

Clark, L., Roiser, J. P., Cools, R., Rubinsztein, D. C., Sahakian, B. J., & Robbins, T. W. (2005) · Psychopharmacology

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 175

Apolipoprotein E Genetic Variation and Alzheimer’s Disease

Rubinsztein, D. C., & Easton, D. F. (1999) · Dementia and Geriatric Cognitive Disorders

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 151

Autophagy and misfolded proteins in neurodegeneration

Metcalf, D. J., García-Arencibia, M., Hochfeld, W. E., & Rubinsztein, D. C. (2012) · Experimental Neurology

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 138

Protein misfolding disorders and macroautophagy

Menzies, F. M., Moreau, K., & Rubinsztein, D. C. (2011) · Current Opinion in Cell Biology

Autophagy in Disease and TherapyHeat shock proteins research

Cited by 129

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Festa, B. P., Siddiqi, F. H., Jimenez-Sanchez, M., Won, H., Rob, M., Djajadikerta, A., Stamatakou, E., & Rubinsztein, D. C. (2023) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAutophagy in Disease and Therapy

Cited by 129

Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.

Roiser, J. P., Blackwell, A. D., Cools, R., Clark, L., Rubinsztein, D. C., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Cited by 98

Autophagy in Neuronal Development and Plasticity

Fleming, A., & Rubinsztein, D. C. (2020) · Trends in Neurosciences

Autophagy in Disease and TherapyNeurogenesis and neuroplasticity mechanisms

Cited by 93

Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

Mallucci, G. R., Klenerman, D., & Rubinsztein, D. C. (2020) · Annual Review of Cell and Developmental Biology

Heat shock proteins researchAlzheimer's disease research and treatments

Cited by 62

Erratum: Serotonin Transporter Polymorphism Mediates Vulnerability to Loss of Incentive Motivation Following Acute Tryptophan Depletion

Roiser, J. P., Blackwell, A. D., Cools, R., Clark, L., Rubinsztein, D. C., Robbins, T. W., & Sahakian, B. J. (2006) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Cited by 47

Protective roles for induction of autophagy in multiple proteinopathies

Menzies, F. M., Ravikumar, B., & Rubinsztein, D. C. (2006) · Autophagy

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 45

Spinocerebellar ataxias caused by polyglutamine expansions: A review of therapeutic strategies

Underwood, B. R., & Rubinsztein, D. C. (2008) · The Cerebellum

Genetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis Research

Cited by 44

The pleiotropic roles of autophagy in Alzheimer’s disease: From pathophysiology to therapy

Festa, B. P., Barbosa, A. D., Rob, M., & Rubinsztein, D. C. (2021) · Current Opinion in Pharmacology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 41

A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo

Cassidy, L. D., Young, A. R., Pérez-Mancera, P. A., Nimmervoll, B., Jaulim, A., Chen, H.-C., McIntyre, D. J. O., Brais, R., Ricketts, T., Pacey, S., et al. (2018) · Autophagy

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 40

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people

Cluett, C., Brayne, C., Clarke, R., Evans, G., Matthews, F., Rubinsztein, D. C., Huppert, F., Llewellyn, D. J., Rice, N., Henley, W., et al. (2010) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 12

USP7 protects TFEB from proteasome-mediated degradation

Keshri, S., Vicinanza, M., Takla, M., & Rubinsztein, D. C. (2024) · Cell Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 8

PSMC5 insufficiency and P320R mutation impair proteasome function

Yu, Z.-Q., Carmichael, J., Collins, G. A., D'Agostino, M. D., Lessard, M., Firth, H. V., Harijan, P., Fry, A. E., Dean, J., Zhang, J., et al. (2024) · Human Molecular Genetics

Ubiquitin and proteasome pathwaysGenetics and Neurodevelopmental Disorders

Cited by 4