Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease
Open accessAbstract
The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Single-center studies have linked post-HCT intestinal microbiota features to relapse, GVHD, infection, organ toxicity, and overall survival.
“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [9]
Patient 2 at colitis had mostly Gammaproteobacteria, mainly Escherichia, a pattern common in disturbed intestinal states.
“and a predominance of Gammaproteobacteria (predominantly Escherichia) in the second patient, which is commonly seen in perturbed intestinal states22.”
From Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis (2018) · cites this paper as [22]
In hematological malignancies, intestinal bacteria affect infection risk and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
“In hematological malignancies, intestinal bacteria also modulate the risk of infection and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (ASCT).”
From The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies (2018) · cites this paper as [17]
Early systemic broad-spectrum antibiotics during ASCT were associated with more GVHD and worse transplant-related mortality, likely by depleting protective Clostridiales and Blautia.
“Early administration of systemic broadspectrum antibiotics in ASCT was associated with increased GVHD, and worse transplant-related mortality, presumably by depleting protective Clostridiales and Blautia in the intestinal microbiota (17).”
From The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies (2018) · cites this paper as [17]
High Blautia abundance is associated with reduced GVHD lethality in two independent allogeneic stem cell transplant cohorts.
“A high abundance of the genus Blautia of the Clostridia class was found to be associated with reduced GVHD lethality in two independent cohorts of patients undergoing treatment with allo-HSCT”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Jenq et al., 2015
Higher abundance of the genus Blautia is associated with improved overall survival after allogeneic stem cell transplant.
“a higher abundance of bacteria within the genus Blautia associated with improved overall survival”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Jenq et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Measuring biological diversity
Magurran, A. E. (2004) · Choice Reviews Online · doi:10.5860/choice.42-1547 · Cited by 6,617 · see citing works
Measuring Biological Diversity
Reid, J. R. W. (2005) · Austral Ecology · doi:10.1111/j.1442-9993.2005.01502.x · Cited by 4,471 · see citing works
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works
Mathematical Theory of Communication
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_3338 · Cited by 2,297 · see citing works
Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies
Schloss, P. D., Gevers, D., & Westcott, S. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027310 · Cited by 2,112 · see citing works
Defining the Intensity of Conditioning Regimens: Working Definitions
Bacigalupo, A. P., Ballen, K. K., Rizzo, J. D., Giralt, S., Lazarus, H. M., Ho, V. T., Apperley, J. F., Slavin, S., Pasquini, M. C., Sandmaier, B. M., et al. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.07.004 · Cited by 1,816 · see citing works
Self-citationSolomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J. C., Baron, E. J., O’Neill, P. J., Chow, A. W., Dellinger, E. P., Eachempati, S. R., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/649554 · Cited by 1,571 · see citing works
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
Chen, W., Liu, F., Ling, Z., Tong, X., & Xiang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039743 · Cited by 1,029 · see citing works
Taur, Y., Xavier, J. B., Lipuma, L., Ubeda, C., Goldberg, J., Gobourne, A., Lee, Y. J., Dubin, K. A., Socci, N. D., Viale, A., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis580 · Cited by 1,020 · see citing works
Self-citationEpithelial antimicrobial defence of the skin and intestine
Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 959 · see citing works
Taur, Y., Jenq, R. R., Perales, M.-A., Littmann, E. R., Morjaria, S., Ling, L., No, D., Gobourne, A., Viale, A., Dahi, P. B., et al. (2014) · Blood · doi:10.1182/blood-2014-02-554725 · Cited by 885 · see citing works
Self-citationRussell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775 · see citing works
Risk factors for acute GVHD and survival after hematopoietic cell transplantation
Jagasia, M., Arora, M., Flowers, M. E. D., Chao, N. J. A., McCarthy, P. L., Cutler, C. S., Urbano-Ispizúa, Á., Pavletic, S. Z., Haagenson, M. D., Zhang, M., et al. (2011) · Blood · doi:10.1182/blood-2011-06-364265 · Cited by 706 · see citing works
Rowlings, P. A., Przepiorka, D., Klein, J. P., Gale, R. P., Passweg, J. R., Henslee‐Downey, P. J., Cahn, J.-Y. Y., Calderwood, S., Gratwohl, A. A., Socié, G., et al. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.1112925.x · Cited by 686 · see citing works
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112408 · Cited by 626 · see citing works
Self-citationHoller, E., Butzhammer, P., Schmid, K., Hundsrucker, C., Koestler, J., Peter, K., Zhu, W., Sporrer, D., Hehlgans, T., Kreutz, M., et al. (2014) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2014.01.030 · Cited by 544 · see citing works
Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 525 · see citing works
Storb, R. F., Prentice, R. L., Buckner, C. D., Clift, R. A., Appelbaum, F. R., Deeg, J., Doney, K., Hansen, J. A., Mason, M. W., Sanders, J. E., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302103080602 · Cited by 431 · see citing works
ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death
Lugt, M. T. V., Braun, T., Hanash, S., Ritz, J., Ho, V. T., Antin, J. H., Zhang, Q., Wong, C., Wang, H., Chin, A. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1213299 · Cited by 403 · see citing works
Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65208-0 · Cited by 359 · see citing works
Bekkum, D. W. V., Roodenburg, J., Heidt, P. J., & Waaij, D. V. D. (1974) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/52.2.401 · Cited by 330 · see citing works
Weisdorf, D. J., Haake, R. J., Blazar, B. R., Miller, W. J., McGlave, P. B., Ramsay, N. K. C., Kersey, J., & Filipovich, A. H. (1991) · Transplantation · doi:10.1097/00007890-199106000-00010 · Cited by 275 · see citing works
Beelen, D. W., Elmaagacli, A. H., Müller, K., Hirche, H., & Schaefer, U. W. (1999) · Blood · doi:10.1182/blood.v93.10.3267.410k22_3267_3275 · Cited by 270 · see citing works
Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD
Vigorito, A. C., Campregher, P. V., Storer, B. E., et al. (2009) · Blood · doi:10.1182/blood-2009-03-208983 · Cited by 257 · see citing works
Clifford, R., Milillo, M., Prestwood, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048558 · Cited by 255 · see citing works
Mortality and Gross Pathology of Secondary Disease in Germfree Mouse Radiation Chimeras
Jones, J. M., Wilson, R., & Bealmear, P. M. (1971) · Radiation Research · doi:10.2307/3573066 · Cited by 211 · see citing works
Hahn, T., McCarthy, P. L., Zhang, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.6545 · Cited by 203 · see citing works
Probiotic effects on experimental graft-versus-host disease: let them eat yogurt
Gerbitz, A., Schultz, M., Wilke, A., Linde, H.-J., Schölmerich, J., Andreesen, R., & Holler, E. (2004) · Blood · doi:10.1182/blood-2003-11-3769 · Cited by 186 · see citing works
Pharmacokinetics of vancomycin
Moellering, R. C. (1984) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/14.suppl_d.43 · Cited by 178 · see citing works
Martin, P. J., McDonald, G. B., Sanders, J. E., et al. (2004) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2003.12.304 · Cited by 154 · see citing works
A Scheme for Defining Cause of Death and Its Application in the T Cell Depletion Trial
Copelan, E. A., Casper, J. T., Carter, S. L., van Burik, J. H., Hurd, D. D., Mendizabal, A. M., Wagner, J. E., Yanovich, S., & Kernan, N. A. (2007) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2007.08.047 · Cited by 154 · see citing works
Ahmad, T., Fiuzat, M., Neely, B., Neely, M. L., Pencina, M. J., Kraus, W. E., Zannad, F. M., Whellan, D. J., Donahue, M., Piña, I. L., et al. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.12.004 · Cited by 139 · see citing works
Influence of protective isolation on outcome of allogeneic bone marrow transplantation for leukemia
Passweg, J. R., Rowlings, P. A., Atkinson, K., Barrett, A., Rp, G., Gratwohl, A. A., Jacobsen, N. O., Klein, J., Ljungman, P. T., Russell, J., et al. (1998) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701238 · Cited by 137 · see citing works
Vossen, J. M. J. J., Heidt, P. J., van den Berg, H., Gerritsen, E. J. A., Hermans, J., & Dooren, L. J. (1990) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01969527 · Cited by 123 · see citing works
Séguy, D., Berthon, C., Micol, J., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000229419.73428.ff · Cited by 108 · see citing works
Blautia faecis sp. nov., isolated from human faeces
Park, S.-K., Kim, M., & Bae, J. (2012) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.036541-0 · Cited by 102 · see citing works
MacMillan, M. L., DeFor, T. E., & Weisdorf, D. J. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09114.x · Cited by 97 · see citing works
Time‐Dependent Predictive Accuracy in the Presence of Competing Risks
Saha‐Chaudhuri, P., & Heagerty, P. J. (2010) · Biometrics · doi:10.1111/j.1541-0420.2009.01375.x · Cited by 94 · see citing works
Malard, F., Szydlo, R., Brissot, É., et al. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.08.010 · Cited by 80 · see citing works
Jakubowski, A. A., Small, T. N., Kernan, N. A., et al. (2011) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2011.01.005 · Cited by 79 · see citing works
Russell, J., Chaudhry, A., Booth, K., Brown, C., Woodman, R. C., Valentine, K., Stewart, D., Ruether, J. D., Ruether, B. A., Jones, A. R., et al. (2000) · Transplantation and Cellular Therapy · doi:10.1016/s1083-8791(00)70073-5 · Cited by 69 · see citing works
Ponce, D. M., Gonzales, A., Lubin, M. N., et al. (2013) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2013.02.008 · Cited by 68 · see citing works
Self-citationTheurich, S., Fischmann, H., Shimabukuro‐Vornhagen, A., Chemnitz, J. M., Holtick, U., Scheid, C., Skoetz, N., & von Bergwelt‐Baildon, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009159.pub2 · Cited by 56 · see citing works
Petersen, F. B., Buckner, C. D., Clift, R. A., Nelson, N., Counts, G. W., Meyers, J. D., & Thomas, E. D. (1987) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548709032423 · Cited by 56 · see citing works
Goldberg, J. D., Linker, A., Kuk, D., et al. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2012.09.003 · Cited by 44 · see citing works
Self-citationJaffe, D., Jakubowski, A. A., Sepkowitz, K. A., Sebti, R., Kiehn, T. E., Pamer, E. G., & Papanicolaou, G. A. (2004) · Clinical Infectious Diseases · doi:10.1086/425612 · Cited by 34 · see citing works
Self-citationBarrell, C., Dietzen, D., Jin, Z., et al. (2012) · Oncology nursing forum · doi:10.1188/12.onf.e451-e458 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392 · see citing works
The microbiome, cancer, and cancer therapy
Helmink, B. A., Khan, M. A. W., Hermann, A., Gopalakrishnan, V., & Wargo, J. A. (2019) · Nature Medicine · doi:10.1038/s41591-019-0377-7 · Cited by 1,200 · see citing works
Microbiota: a key orchestrator of cancer therapy
Roy, S., & Trinchieri, G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.13 · Cited by 883 · see citing works
The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies
Zitvogel, L., Ma, Y., Raoult, D., Kroemer, G., & Gajewski, T. F. (2018) · Science · doi:10.1126/science.aar6918 · Cited by 777 · see citing works
Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation
Peled, J. U., Gomes, A. L. C., Devlin, S. M., Littmann, E. R., Taur, Y., Sung, A. D., Weber, D., Hashimoto, D., Slingerland, A. E., Slingerland, J. B., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1900623 · Cited by 765 · see citing works
Self-citationFecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
Wang, Y., Wiesnoski, D. H., Helmink, B. A., Gopalakrishnan, V., Choi, K., DuPont, H. L., Jiang, Z.-D., Abu-Sbeih, H., Sanchez, C. A., Chang, C.-C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0238-9 · Cited by 740 · see citing works
Self-citationShono, Y., Docampo, M. D., Peled, J. U., Perobelli, S. M., Velardi, E., Tsai, J. J., Slingerland, A. E., Smith, O. M., Young, L. F., Gupta, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2311 · Cited by 592 · see citing works
Self-citationLactose drives <i>Enterococcus</i> expansion to promote graft-versus-host disease
Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., et al. (2019) · Science · doi:10.1126/science.aax3760 · Cited by 384 · see citing works
Self-citationModulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376 · see citing works
Kakihana, K., Fujioka, Y., Suda, W., Najima, Y., Kuwata, G., Sasajima, S., Mimura, I., Morita, H., Sugiyama, D., Nishikawa, H., et al. (2016) · Blood · doi:10.1182/blood-2016-05-717652 · Cited by 367 · see citing works
The Oral Microbiome and Cancer
Irfan, M., Delgado, R. Z. R., & Frias-Lopez, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591088 · Cited by 341 · see citing works
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
Smith, M., Dai, A., Ghilardi, G., Amelsberg, K. V., Devlin, S. M., Pajarillo, R., Slingerland, J. B., Beghi, S., Herrera, P. S., Giardina, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01702-9 · Cited by 349 · see citing works
Self-citationIntestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation
Peled, J. U., Devlin, S. M., Staffas, A., Lumish, M., Khanin, R., Littmann, E. R., Ling, L., Kosuri, S., Maloy, M., Slingerland, J. B., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.3348 · Cited by 325 · see citing works
Self-citationSpecific Gut Microbiome Signature Predicts the Early-Stage Lung Cancer
Zheng, Y., Fang, Z., Xue, Y., Zhang, J., Zhu, J., Gao, R., Yao, S., Ye, Y., Wang, S., Lin, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1737487 · Cited by 301 · see citing works
Weber, D., Jenq, R. R., Peled, J. U., Taur, Y., Hiergeist, A., Koestler, J., Dettmer, K., Weber, M., Wolff, D., Hahn, J., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2017.02.006 · Cited by 245 · see citing works
Self-citationElkrief, A., Derosa, L., Kroemer, G., Zitvogel, L., & Routy, B. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz206 · Cited by 246 · see citing works
Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243 · see citing works
Golob, J. L., Pergam, S. A., Srinivasan, S., Fiedler, T. L., Liu, C., Garcia, K., Mielcarek, M., Ko, D., Aker, S., Marquis, S., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix699 · Cited by 201 · see citing works
Weber, D., Oefner, P. J., Hiergeist, A., Koestler, J., Gessner, A., Weber, M., Hahn, J., Wolff, D., Stämmler, F., Spang, R., et al. (2015) · Blood · doi:10.1182/blood-2015-04-638858 · Cited by 195 · see citing works
Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?
Derosa, L., Routy, B., Desilets, A., Daillère, R., Terrisse, S., Kroemer, G., & Zitvogel, L. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0236 · Cited by 170 · see citing works
Zeng, X., Li, X., Li, X., Wei, C., Shi, C., Hu, K., Kong, D., Luo, Q., Xu, Y., Shan, W., et al. (2023) · Blood · doi:10.1182/blood.2022017514 · Cited by 157 · see citing works
Galloway-Peña, J. R., Shi, Y., Peterson, C. B., Sahasrabhojane, P., Gopalakrishnan, V., Brumlow, C. E., Daver, N. G., Alfayez, M., Boddu, P. C., Khan, M. A. W., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciz777 · Cited by 140 · see citing works
Self-citationNewsome, R. C., Gharaibeh, R. Z., Pierce, C. M., da Silva, W. V., Paul, S., Hogue, S. R., Yu, Q., Antonia, S., Conejo-Garcia, J. R., Robinson, L. A., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01037-7 · Cited by 104 · see citing works
Weber, D., Hiergeist, A., Weber, M., Dettmer, K., Wolff, D., Hahn, J., Herr, W., Gessner, A., & Holler, E. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy711 · Cited by 92 · see citing works
Liu, P., Jia, X., Chen, Y., Yu, Y., Zhang, K., Lin, Y., Wang, B., & Peng, G. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13451 · Cited by 87 · see citing works
Routy, B., Letendre, C., Enot, D., Chénard-Poirier, M., Mehraj, V., Séguin, N. C., Guenda, K., Gagnon, K., Woerther, P.-L., Ghez, D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1258506 · Cited by 75 · see citing works
Roles of the intestinal microbiota and microbial metabolites in acute GVHD
Lin, D., Hu, B., Li, P., Zhao, Y., Xu, Y., & Wu, D. (2021) · Experimental Hematology & Oncology · doi:10.1186/s40164-021-00240-3 · Cited by 71 · see citing works
McQuade, J. L., Ologun, G. O., Arora, R., & Wargo, J. A. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00913-y · Cited by 63 · see citing works
Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy
Davar, D., & Zarour, H. M. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1129 · Cited by 40 · see citing works
Wang, X., Shang, Y., Wei, Q., Wu, X., Dou, H., Zhang, H., Zhou, S., Sha, W., Sun, G., Ma, S., et al. (2022) · Microbial Ecology · doi:10.1007/s00248-021-01806-8 · Cited by 36 · see citing works
Hidaka, D., Hayase, E., Shiratori, S., Hasegawa, Y., Ishio, T., Tateno, T., Okada, K., Goto, H., Sugita, J., Onozawa, M., et al. (2018) · Clinical Transplantation · doi:10.1111/ctr.13361 · Cited by 39 · see citing works
Xie, X., Liao, J., Ai, Y., Gao, J., Zhao, J., Qu, F., Xu, C., Zhang, Z., Wen, W., Cui, H., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.748872 · Cited by 37 · see citing works
Bugs as drugs: The role of microbiome in cancer focusing on immunotherapeutics
Araujo, D. V., Watson, G. A., Oliva, M., Heirali, A., Coburn, B., Spreafico, A., & Siu, L. L. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102125 · Cited by 29 · see citing works
Applications of gut microbiota in patients with hematopoietic stem-cell transplantation
Yu, J., Sun, H., Cao, W., Han, L., Song, Y., Wan, D., & Jiang, Z. (2020) · Experimental Hematology & Oncology · doi:10.1186/s40164-020-00194-y · Cited by 25 · see citing works
The role of microbiota in allogeneic hematopoietic stem cell transplantation
Chang, C.-C., Hayase, E., & Jenq, R. R. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1872541 · Cited by 20 · see citing works
Self-citation
- Authors
- Jenq, R. R., Taur, Y., Devlin, S. M., Ponce, D. M., Goldberg, J. D., Ahr, K. F., Littmann, E. R., Ling, L., Gobourne, A. C., Miller, L. C., Docampo, M. D., Peled, J. U., Arpaia, N., Cross, J. R., Peets, T. K., Lumish, M. A., Shono, Y., Dudakov, J. A., Poeck, H., Hanash, A. M., Barker, J. N., Perales, M.-A., Giralt, S. A., Pamer, E. G., & van den Brink, M. R. M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Jenq, Robert R.
- ORCID
- Jenq, Robert R.
- Taur, Ying
- Devlin, Sean M.
- Ponce, Doris M.
- Ahr, Katya F.
- Littmann, Eric R.
- Ling, Lilan
- Miller, Liza C.
- Docampo, Melissa D.
- Peled, Jonathan U.
- Arpaia, Nicholas
- Cross, Justin R.
- Lumish, Melissa A.
- Shono, Yusuke
- Dudakov, Jarrod A.
- Poeck, Hendrik
- Hanash, Alan M.
- Barker, Juliet N.
- Perales, Miguel-Angel
- Giralt, Sergio A.
- Pamer, Eric G.
- Venue
- Biology of Blood and Marrow Transplantation
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 21
- Issue
- 8
- Pages
- 1373-1383
- ISSN
- 1083-8791 (ISSN-L)
- PMC
- PMC4516127
- OpenAlex
- W1592407962
- Cited by
- 748
- References
- 57
- Citations by year
- 2026: 33 · 2025: 47 · 2024: 50 · 2023: 81 · 2022: 102 · 2021: 107 · 2020: 119 · 2019: 71 · 2018: 52 · 2017: 48 · 2016: 33 · 2015: 5
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Transplantation and Cellular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- National Institutes of Health (R01-HL069929, R01-AI080455, R01-AI101406, P01-CA023766, P30-CA008748, R01-AI042135, R01-AI095706, K23-AI095398)
- U.S National Institute of Allergy and Infectious Diseases
- The Experimental Therapeutics Center of Memorial Sloan Kettering Cancer Center
- The Lymphoma Foundation
- Alex's Lemonade Stand
- The Geoffrey Beene Cancer Research Center at Memorial Sloan Kettering Cancer Center
- Lucille Castori Center for Microbes, Inflammation, and Cancer
- Tow Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- Blautia, graft-versus-host disease, gut microbiota, bacterial diversity, commensal bacteria, overall survival, antibiotic therapy, total parenteral nutrition, anaerobic bacteria
- MeSH terms
- Bacteria, Female, Graft vs Host Disease, Humans, Intestinal Mucosa, Intestines, Male, Risk Factors, Cohort Studies, Survival Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
