Assimes, Themistocles L.

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

Vujkovic, M., Ramdas, S., Lorenz, K. M., Guo, X., Darlay, R., Cordell, H. J., He, J., Gindin, Y., Chung, C., Myers, R. P., et al. (2022) · Nature Genetics

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 205

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 196

Characterizing the admixed African ancestry of African Americans

Zakharia, F., Basu, A., Absher, D., Assimes, T. L., Go, A. S., Hlatky, M. A., Iribarren, C., Knowles, J. W., Li, J., Narasimhan, B., et al. (2009) · Genome Biology

Forensic and Genetic ResearchRace, Genetics, and Society

Cited by 185

Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study

Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S. (2017) · Biological Psychiatry

Sleep and related disordersEpigenetics and DNA Methylation

Cited by 173

Genomics and phenomics of body mass index reveals a complex disease network

Huang, J., Huffman, J. E., Huang, Y., Do Valle, Í., Assimes, T. L., Raghavan, S., Voight, B. F., Liu, C., Barabási, A.-L., Huang, R. D. L., et al. (2022) · Nature Communications

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 170

A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

Huan, T., Zhang, B., Wang, Z., Joehanes, R., Zhu, J., Johnson, A. D., Ying, S., Munson, P. J., Raghavachari, N., Wang, R., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 167

Association of Left Ventricular Ejection Fraction and Symptoms With Mortality After Elective Noncardiac Surgery Among Patients With Heart Failure

Lerman, B. J., Popat, R. A., Assimes, T. L., Heidenreich, P. A., & Wren, S. M. (2019) · JAMA

Cardiac, Anesthesia and Surgical OutcomesHeart Failure Treatment and Management

Cited by 148

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., Hansson, O., Pankow, J., Goodarzi, M. O., Carcamo-Orive, I., et al. (2015) · Journal of Clinical Investigation

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 141

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., Alkayyali, S., Assimes, T. L., Quertermous, T., Abbasi, F., Paananen, J., et al. (2013) · Diabetes

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 83

The Project Baseline Health Study: a step towards a broader mission to map human health

Arges, K., Assimes, T., Bajaj, V., Balu, S., Bashir, M. R., Beskow, L., Blanco, R., Califf, R., Campbell, P., Carin, L., et al. (2020) · npj Digital Medicine

Health, Environment, Cognitive AgingArtificial Intelligence in Healthcare and Education

Cited by 82

Leveraging population admixture to characterize the heritability of complex traits

Zaitlen, N., Pasaniuc, B., Sankararaman, S., Bhatia, G., Zhang, J., Gusev, A., Young, T., Tandon, A., Pollack, S., Vilhjálmsson, B. J., et al. (2014) · Nature Genetics

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 63

Low lifetime recreational activity is a risk factor for peripheral arterial disease

Wilson, A. M., Sadrzadeh-Rafie, A. H., Myers, J., Assimes, T., Nead, K. T., Higgins, M., Gabriel, A., Olin, J., & Cooke, J. P. (2011) · Journal of Vascular Surgery

Peripheral Artery Disease ManagementPhysical Activity and Health

Cited by 45

Breastfeeding Duration and the Risk of Coronary Artery Disease

Rajaei, S., Rigdon, J., Crowe, S., Tremmel, J., Tsai, S., & Assimes, T. L. (2019) · Journal of Women's Health

Breastfeeding Practices and InfluencesCancer Risks and Factors

Cited by 43

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Program, T. V. M. V., Bone, W. P., Siewert, K. M., Jha, A., Klarin, D., Damrauer, S. M., Chang, K.-M., Tsao, P. S., Assimes, T. L., Ritchie, M. D., et al. (2021) · Alzheimer's Research & Therapy

Genetic Associations and EpidemiologyAlzheimer's disease research and treatments

Cited by 41

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry

Satterfield, B. A., Dikilitas, O., Safarova, M. S., Clarke, S. L., Tcheandjieu, C., Zhu, X., Bastarache, L., Larson, E. B., Justice, A. E., Shang, N., et al. (2021) · Circulation: Genomic and Precision Medicine

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 40

Coffee Consumption Is Associated with DNA Methylation Levels of Human Blood

Chuang, Y.-H., Quach, A., Absher, D., Assimes, T., Horvath, S., & Ritz, B. (2017) · European Journal of Human Genetics

Epigenetics and DNA MethylationCoffee research and impacts

Cited by 40

Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers

Smith-Byrne, K., Hedman, Å., Dimitriou, M., Desai, T., Sokolov, A. V., Schioth, H. B., Koprulu, M., Pietzner, M., Langenberg, C., Atkins, J., et al. (2024) · Nature Communications

Genetic Associations and EpidemiologyCancer Genomics and Diagnostics

Cited by 33

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

Small, A. M., Huffman, J. E., Klarin, D., Lynch, J. A., Assimes, T., DuVall, S., Sun, Y. V., Shere, L., Natarajan, P., Gaziano, M., et al. (2020) · PLOS ONE

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 19

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and diseases

Macdonald-Dunlop, E., Klarić, L., Folkersen, L., Timmers, P. R. H. J., Gustafsson, S., Zhao, J. H., Eriksson, N., Richmond, A., Enroth, S., Mattsson-Carlgren, N., et al. (2021) · medRxiv

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 9