Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study
Open accessAbstract
BACKGROUND: Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortality. METHODS: We examined the association of epigenetic age and immune cell aging with sleep in the Women's Health Initiative study (N = 2078; mean 64.5 ± 7.1 years of age) with assessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble getting back to sleep, and early awakenings), sleep duration (short sleep 5 hours or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and late differentiated T cells (CD8+CD28-CD45RA-). RESULTS: Insomnia symptoms were related to advanced epigenetic age (β ± SE = 1.02 ± 0.37, p = .005) after adjustments for covariates. Insomnia symptoms were also associated with more late differentiated T cells (β ± SE = 0.59 ± 0.21, p = .006), but not with naive T cells. Self-reported short and long sleep duration were unrelated to epigenetic age. Short sleep, but not long sleep, was associated with fewer naive T cells (p < .005) and neither was related to late differentiated T cells. CONCLUSIONS: Symptoms of insomnia were associated with increased epigenetic age of blood tissue and were associated with higher counts of late differentiated CD8+ T cells. Short sleep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline in naive T cells. In this large population-based study of women in the United States, insomnia symptoms are implicated in accelerated aging.
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Some studies reported an association of cytokines and other inflammatory proteins with short sleep duration, generally defined as <5 or 6 h compared with a reference range of 7-8 h.
“some studies reported an association of these markers with short sleep duration, generally defined as <5 or 6 h of sleep compared with a reference range of 7–8 h of sleep”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [92]
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- Authors
- Carroll, J. E., Irwin, M. R., Levine, M., Seeman, T. E., Absher, D., Assimes, T., & Horvath, S.
- Affiliations
- University of California, Los Angeles (US)
- HudsonAlpha Institute for Biotechnology (US)
- Stanford University (US)
- Corresponding author
- Carroll, Judith E.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 81
- Issue
- 2
- Pages
- 136-144
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5536960
- OpenAlex
- W2479582436
- Cited by
- 173
- References
- 76
- Citations by year
- 2026: 21 · 2025: 19 · 2024: 27 · 2023: 21 · 2022: 17 · 2021: 15 · 2020: 12 · 2019: 23 · 2018: 13 · 2017: 5
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biological Psychiatry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- University of California, Los Angeles
- U.S. Department of Health and Human Services (HHSN268201100046C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C, HHSN271201100004C)
- Norman Cousins Center for Psychoneuroimmunology
- National Institute on Drug Abuse (R01 DA032922)
- National Institute on Aging (5R01AG042511–02, K01 AG044462, R01 AG026364, R01 AG034588)
- National Heart, Lung, and Blood Institute (60442456 BAA23, P30 AG017265, R01 HL095799-01, R24AG037898)
- National Cancer Institute (R01 CA160245)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- insomnia symptoms, epigenetic aging, immunosenescence, DNA methylation clocks, accelerated biological aging, naive T cells, CD8+ T cells, sleep duration, short sleep duration, long sleep, women's health
- MeSH terms
- Immunosenescence, Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Female, Humans, Sleep Initiation and Maintenance Disorders, Middle Aged, T-Lymphocytes, United States, Women's Health, DNA Methylation, Epigenesis, Genetic
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