Stephanopoulos, Gregory

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1,791

Engineering cell shape and function

Singhvi, R., Kumar, A., Lopez, G. P., Stephanopoulos, G. N., Wang, D. I. C., Whitesides, G. M., & Ingber, D. E. (1994) · Science

Cellular Mechanics and InteractionsNanofabrication and Lithography Techniques

Cited by 1,453

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,120

Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production

Alper, H., Moxley, J., Nevoigt, E., Fink, G. R., & Stephanopoulos, G. (2006) · Science

Microbial Metabolic Engineering and BioproductionFungal and yeast genetics research

Cited by 823

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J.-K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., et al. (2012) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 816

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 799

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Csibi, A., Fendt, S.-M., Li, C., Poulogiannis, G., Choo, A. Y., Chapski, D. J., Jeong, S. M., Dempsey, J. M., Parkhitko, A., Morrison, T., et al. (2013) · Cell

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 586

Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth

Gaglio, D., Metallo, C. M., Gameiro, P. A., Hiller, K., Danna, L. S., Balestrieri, C., Alberghina, L., Stephanopoulos, G., & Chiaradonna, F. (2011) · Molecular Systems Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 492

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., et al. (2008) · Cell Metabolism

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 469

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Fendt, S.-M., Bell, E. L., Keibler, M. A., Olenchock, B. A., Mayers, J. R., Wasylenko, T. M., Vokes, N. I., Guarente, L., Heiden, M. G. V., & Stephanopoulos, G. (2013) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 364

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., et al. (2017) · Nature Medicine

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 331

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

Gameiro, P. A., Yang, J., Metelo, A. M., Pérez-Carro, R., Baker, R., Wang, Z., Arreola, A., Rathmell, W. K., Olumi, A., López-Larrubia, P., et al. (2013) · Cell Metabolism

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 325

Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line

Yoo, H., Antoniewicz, M. R., Stephanopoulos, G., & Kelleher, J. K. (2008) · Journal of Biological Chemistry

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 301

Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae

Zhou, H., Cheng, J.-S., Wang, B. L., Fink, G. R., & Stephanopoulos, G. (2012) · Metabolic Engineering

Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversion

Cited by 287

Microbial Competition

Fredrickson, A. G., & Stephanopoulos, G. (1981) · Science

Microbial Community Ecology and PhysiologyEvolution and Genetic Dynamics

Cited by 281

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

Metallo, C. M., Walther, J. L., & Stephanopoulos, G. (2009) · Journal of Biotechnology

Microbial Metabolic Engineering and BioproductionCancer, Hypoxia, and Metabolism

Cited by 280

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Hung, Y. P., Teragawa, C., Kosaisawe, N., Gillies, T. E., Pargett, M., Minguet, M., Distor, K., Rocha-Gregg, B. L., Coloff, J. L., Keibler, M. A., et al. (2017) · eLife

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 74

Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model

Islam, M. A., Zengler, K., Edwards, E. A., Mahadevan, R., & Stephanopoulos, G. (2015) · Integrative Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 41

Monoterpenoid biosynthesis by engineered microbes

Liu, Y., Ma, X., Liang, H., Stephanopoulos, G., & Zhou, K. (2021) · Journal of Industrial Microbiology and Biotechnology

Microbial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis

Cited by 34