The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Cox’s regression model for counting processes: A large sample study

Andersen, P. K., & Gill, R. D. (1982) · The Annals of Statistics · doi:10.1214/aos/1176345976 · Cited by 4,419 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

mTOR: from growth signal integration to cancer, diabetes and ageing

Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555 · see citing works

Regulation of TORC1 by Rag GTPases in nutrient response

Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349 · see citing works

Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

Bissler, J. J., McCormack, F. X., Young, L. R., Elwing, J., Chuck, G., Leonard, J. M., Schmithorst, V. J., Laor, T., Brody, A. S., Bean, J. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa063564 · Cited by 1,250 · see citing works

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Reitzer, L. J., Wice, B. M., & Kennell, D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30124-2 · Cited by 1,240 · see citing works

The role of microRNA genes in papillary thyroid carcinoma

He, H., Jażdżewski, K., Li, W., Liyanarachchi, S., Nagy, R. S., Volinia, S., Calin, G. A., Liu, C., Franssila, K., Suster, S. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509603102 · Cited by 1,212 · see citing works

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.057 · Cited by 1,162 · see citing works

Efficacy and safety of sirolimus in lymphangioleiomyomatosis

McCormack, F. X., Inoue, Y., Moss, J., Singer, L. G., Strange, C., Nakata, K., Barker, A. F., Chapman, J. T., Brantly, M. L., Stocks, J. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1100391 · Cited by 1,099 · see citing works

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095 · see citing works

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., & Gorbunova, V. (2011) · Science · doi:10.1126/science.1202723 · Cited by 867 · see citing works

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829 · see citing works

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

Wang, J.-B., Erickson, J. W., Fuji, R., Ramachandran, S., Gao, P., Dinavahi, R., Wilson, K. F., Ambrosio, A. L. B., Dias, S. M. G., Dang, C. V., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.009 · Cited by 821 · see citing works

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782 · see citing works

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Roux, P. P., Ballif, B. A., Anjum, R., Gygi, S. P., & Blenis, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405659101 · Cited by 750 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Ye, J., Kumanova, M., Hart, L. S., Sloane, K. L., Zhang, H., Panis, D. N. D., Bobrovnikova-Marjon, E. V., Diehl, J. A., Ron, D., & Koumenis, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.81 · Cited by 709 · see citing works

Alkylating DNA damage stimulates a regulated form of necrotic cell deathPreprint

Zong, W., Ditsworth, D., Bauer, D. E., Wang, Z., & Thompson, C. B. (2004) · Genes & Development · doi:10.1101/gad.1199904 · Cited by 618 · see citing works

Gene Expression in the Urinary Bladder

Dyrskjøt, L., Kruhøffer, M., Thykjær, T., Marcussen, N., Jensen, J. L., Møller, K., & Orntoft, T. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3620 · Cited by 452 · see citing works

A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer

Bonome, T., Levine, D. A., Shih, J. H., Randonovich, M., Pise-Masison, C. A., Bogomolniy, F., Ozbun, L. L., Brady, J. N., Barrett, J. C., Boyd, J. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6595 · Cited by 440 · see citing works

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Yang, C., Sudderth, J., Dang, T. T., Bachoo, R. G., McDonald, J. G., & DeBerardinis, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2266 · Cited by 425 · see citing works

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375 · see citing works

Multitargeted therapy of cancer by green tea polyphenols

Khan, N., & Mukhtar, H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.014 · Cited by 365 · see citing works

Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer

Choi, Y., Lim, J. Y., Cheong, J., Park, Y., Yoon, S.-L., Kim, S. M., Kim, S.-B., Kim, H., Hong, S. W., Park, Y. N., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2180 · Cited by 350 · see citing works

Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants

L-C, H. C.-T. V. T. L. S.-Y. T. A. H. H.-M. P. (1993) · Lung Cancer · doi:10.1016/0169-5002(93)90327-t · Cited by 347 · see citing works

Common corruption of the mTOR signaling network in human tumors

Menon, S., & Manning, B. D. (2008) · Oncogene · doi:10.1038/onc.2009.352 · Cited by 328 · see citing works

Genomic Index of Sensitivity to Endocrine Therapy for Breast Cancer

Symmans, W. F., Hatzis, C., Sotiriou, C. P., André, F., Peintinger, F., Regitnig, P., Daxenbichler, G., Desmedt, C., Dômont, J., Marth, C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.4273 · Cited by 282 · see citing works

Accurate Assessment of Amino Acid Mass Isotopomer Distributions for Metabolic Flux Analysis

Antoniewicz, M. R., Kelleher, J. K., & Stephanopoulos, G. N. (2007) · Analytical Chemistry · doi:10.1021/ac0708893 · Cited by 257 · see citing works

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

Choo, A. Y., Kim, S. G., Heiden, M. G. V., Mahoney, S. J., Vu, H., Yoon, S.-O., Cantley, L. C., & Blenis, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.007 · Cited by 248 · see citing works

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

Yoshizawa, T., Hinoi, E., Jung, D. Y., Kajimura, D., Ferron, M., Seo, J. H., Graff, J. M., Kim, J. K., & Karsenty, G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39366 · Cited by 221 · see citing works

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.003 · Cited by 215 · see citing works

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

Yamaguchi, S., Ishihara, H., Yamada, T., Tamura, A., Usui, M., Tominaga, R., Munakata, Y., Satake, C., Katagiri, H., Tashiro, F., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.008 · Cited by 189 · see citing works

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

Whitney, M. L., Jefferson, L. S., & Kimball, S. R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.079 · Cited by 186 · see citing works

mTOR links oncogenic signaling to tumor cell metabolism

Yecies, J. L., & Manning, B. D. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0726-6 · Cited by 183 · see citing works

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

West, M. J., Stoneley, M., & Willis, A. E. (1998) · Oncogene · doi:10.1038/sj.onc.1201990 · Cited by 183 · see citing works

PET Imaging of Glutaminolysis in Tumors by 18 F-( 2S,4R )4-Fluoroglutamine

Lieberman, B. P., Plöessl, K., Wang, L., Qü, W., Zha, Z., Wise, D. R., Chodosh, L. A., Belka, G. K., Thompson, C. B., & Kung, H. F. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.093815 · Cited by 176 · see citing works

Glutamine: pleiotropic roles in tumor growth and stress resistance

Shanware, N. P., Mullen, A. R., DeBerardinis, R. J., & Abraham, R. T. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0731-9 · Cited by 176 · see citing works

ATF4 regulates lipid metabolism and thermogenesis

Wang, C., Huang, Z., Du, Y., Cheng, Y., Chen, S., & Guo, F. (2010) · Cell Research · doi:10.1038/cr.2010.4 · Cited by 165 · see citing works

Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase

Li, C., Allen, A., Kwagh, J., Doliba, N. M., Qin, W. D., Najafi, H., Collins, H. W., Matschinsky, F. M., Stanley, C. A., & Smith, T. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512792200 · Cited by 163 · see citing works

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

Fendt, S., Buescher, J. M., Rudroff, F., Picotti, P., Zamboni, N., & Sauer, U. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.11 · Cited by 159 · see citing works

Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice

Zhang, D., Al-Hendy, M., Richard-Davis, G., Montgomery‐Rice, V., Sharan, C., Rajaratnam, V. S., Khurana, A., & Al-Hendy, A. A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.10.885 · Cited by 100 · see citing works

Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*

Frank, C. L., Ge, X., Xie, Z., Zhou, Y., & Tsai, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.140699 · Cited by 93 · see citing works

The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP

Chérasse, Y., Maurin, A., Chaveroux, C., Jousse, C., Carraro, V., Parry, L., Deval, C., Chambon, C., Fafournoux, P., & Bruhat, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm642 · Cited by 85 · see citing works

Utility of [ 18 F]2-Fluoro-2-Deoxyglucose-PET in Sporadic and Tuberous Sclerosis-Associated Lymphangioleiomyomatosis

Young, L. R., Franz, D. N., Nagarkatte, P., Fletcher, C. D. �., Wikenheiser‐Brokamp, K. A., Galsky, M. D., Corbridge, T. C., Lam, A. P., Gelfand, M. J., & McCormack, F. X. (2009) · CHEST Journal · doi:10.1378/chest.09-0336 · Cited by 37 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Mitochondria and cancer

Vyas, S., Zaganjor, E., & Haigis, M. C. (2016) · Cell · doi:10.1016/j.cell.2016.07.002 · Cited by 1,735 · see citing works

Rapamycin: one drug, many effects

Li, J., Kim, S. G., & Blenis, J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.001 · Cited by 1,287 · see citing works

mTOR signalling and cellular metabolism are mutual determinants in cancer

Mossmann, D., Park, S., & Hall, M. N. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0074-8 · Cited by 1,088 · see citing works

P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Glutaminolysis: A Hallmark of Cancer Metabolism

Yang, L., Venneti, S., & Nagrath, D. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044546 · Cited by 859 · see citing works

The sirtuin family in health and disease

Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 891 · see citing works

Regulation and metabolic functions of mTORC1 and mTORC2.

Szwed, A., Kim, E., & Jacinto, E. (2021) · Physiological Reviews · doi:10.1152/physrev.00026.2020 · Cited by 723 · see citing works

Metabolic targets for cancer therapy

Galluzzi, L., Kepp, O., Heiden, M. G. V., & Kroemer, G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4145 · Cited by 705 · see citing works

Metabolic Reprogramming: the Emerging Concept and Associated Therapeutic Strategies

Yoshida, G. J. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0221-y · Cited by 716 · see citing works

KRAS: feeding pancreatic cancer proliferation

Bryant, K. L., Mancias, J. D., Kimmelman, A. C., & Der, C. J. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.004 · Cited by 675 · see citing works

Metabolites and the Tumour Microenvironment: From Cellular Mechanisms to Systemic Metabolism

Elia, I., & Haigis, M. C. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00317-z · Cited by 651 · see citing works

mTORC1 signaling and the metabolic control of cell growth

Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Park, J. H., Pyun, W. Y., & Park, H. W. (2020) · Cells · doi:10.3390/cells9102308 · Cited by 558 · see citing works

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

Morita, M., Gravel, S.-P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991572 · Cited by 552 · see citing works

NAD+ metabolism, stemness, the immune response, and cancer

Navas, L. E., & Carnero, A. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00354-w · Cited by 529 · see citing works

The role of ubiquitination and deubiquitination in cancer metabolism

Sun, T., Liu, Z., & Yang, Q. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01262-x · Cited by 518 · see citing works

The multifaceted functions of sirtuins in cancer

Chalkiadaki, A., & Guarente, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3985 · Cited by 501 · see citing works

Glutaminolysis as a target for cancer therapy

Jin, L., Alesi, G. N., & Kang, S. (2016) · Oncogene · doi:10.1038/onc.2015.447 · Cited by 459 · see citing works

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works

Tumor glycolysis, an essential sweet tooth of tumor cells

Paul, S., Ghosh, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.007 · Cited by 449 · see citing works

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

Mathias, R. A., Greco, T. M., Oberstein, A., Budayeva, H. G., Chakrabarti, R., Rowland, E. A., Kang, Y., Shenk, T., & Cristea, I. M. (2014) · Cell · doi:10.1016/j.cell.2014.11.046 · Cited by 430 · see citing works

Metabolism of Amino Acids in Cancer

Wei, Z. C., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 439 · see citing works

Mitochondria as biosynthetic factories for cancer proliferation

Ahn, C. S., & Metallo, C. M. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0128-2 · Cited by 399 · see citing works

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 366 · see citing works

Oncogenic Roles of the PI3K/AKT/mTOR axis

Aoki, M., & Fujishita, T. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_6 · Cited by 355 · see citing works

SIRT5 regulation of ammonia-induced autophagy and mitophagy

Polletta, L., Vernucci, E., Carnevale, I., Arcangeli, T., Rotili, D., Palmerio, S., Steegborn, C., Nowak, T., Schutkowski, M., Pellegrini, L., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1009778 · Cited by 350 · see citing works

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

Yang, L., Moss, T., Mangala, L. S., Marini, J., Zhao, H., Wahlig, S., Armaiz‐Pena, G., Jiang, D., Achreja, A., Win, J., et al. (2014) · Molecular Systems Biology · doi:10.1002/msb.20134892 · Cited by 326 · see citing works

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

Yang, W., Nagasawa, K., Münch, C., Xu, Y., Satterstrom, F. K., Jeong, S., Hayes, S., Jedrychowski, M. P., Vyas, F. S., Zaganjor, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.016 · Cited by 341 · see citing works

Targeting <scp>ASCT2</scp>‐mediated glutamine uptake blocks prostate cancer growth and tumour development

Wang, Q., Hardie, R., Hoy, A. J., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M. C., Balaban, S., Schreuder, M., Nagarajah, R., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4518 · Cited by 338 · see citing works

SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion

Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.003 · Cited by 326 · see citing works

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

Carrico, C., Meyer, J. G., He, W., Gibson, B. W., & Verdin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.016 · Cited by 331 · see citing works

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

Salabei, J. K., Gibb, A., & Hill, B. G. (2014) · Nature Protocols · doi:10.1038/nprot.2014.018 · Cited by 326 · see citing works

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells

Coloff, J. L., Murphy, J. P., Braun, C. R., Harris, I. S., Shelton, L. M., Kami, K., Gygi, S. P., Selfors, L. M., & Brugge, J. S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.016 · Cited by 288 · see citing works

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

van de Ven, R. A. H., Santos, D., & Haigis, M. C. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.005 · Cited by 309 · see citing works

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Hao, Y., Samuels, Y., Li, Q., Krokowski, D., Guan, B.-J., Wang, C., Jin, Z., Dong, B., Cao, B., Feng, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms11971 · Cited by 290 · see citing works

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity

Chavez-Dominguez, R., Perez-Medina, M., López-González, J. S., Galicia-Velasco, M., & Aguilar‐Cázares, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.578418 · Cited by 309 · see citing works

Growing knowledge of the mTOR signaling network

Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 301 · see citing works

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 302 · see citing works

The Warburg Effect 97 Years after Its Discovery

Pascale, R. M., Calvisi, D. F., Simile, M. M., Feo, C. F., & Feo, F. (2020) · Cancers · doi:10.3390/cancers12102819 · Cited by 304 · see citing works

mTOR signaling in cellular and organismal energetics

Albert, V., & Hall, M. N. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.001 · Cited by 304 · see citing works

Integrative multi-omics approaches in cancer research: from biological networks to clinical subtypes

Heo, Y. J., Hwa, C., Lee, G.-H., Park, J.-M., & An, J.-Y. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0042 · Cited by 294 · see citing works

Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy

Yang, W., Qiu, Y., Stamatatos, O. T., Janowitz, T., & Lukey, M. J. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.04.003 · Cited by 300 · see citing works

Sirtuins: guardians of mammalian healthspan

Giblin, W., Skinner, M. E., & Lombard, D. B. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.007 · Cited by 280 · see citing works

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

Montal, E. D., Dewi, R. E., Bhalla, K., Ou, L., Hwang, B. J., Ropell, A. E., Gordon, C. R., Liu, W.-J., DeBerardinis, R. J., Sudderth, J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.025 · Cited by 261 · see citing works

ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease

Lüscher, B., Bütepage, M., Eckei, L., Krieg, S., Verheugd, P., & Shilton, B. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00122 · Cited by 258 · see citing works

Amino acid metabolism in tumor biology and therapy

Chen, J., Cui, L., Lu, S., & Xu, S. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06435-w · Cited by 268 · see citing works

The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

Xiao, D., Zeng, L., Kang, Y., Kong, X., Wu, G., & Yin, Y. (2016) · Amino Acids · doi:10.1007/s00726-016-2254-8 · Cited by 246 · see citing works

Mitochondrial sirtuins, metabolism, and aging

Ji, Z., Liu, G., & Qu, J. T. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.11.005 · Cited by 245 · see citing works

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

Tanaka, K., Sasayama, T., Irino, Y., Takata, K., Nagashima, H., Satoh, N., Kyotani, K., Mizowaki, T., Imahori, T., Ejima, Y., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78239 · Cited by 243 · see citing works

Sirtuin regulation in aging and injury

Poulose, N., & Raju, R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.017 · Cited by 236 · see citing works

The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease

Plaitakis, A., Kalef-Ezra, E., Kotzamani, D., Zaganas, I. V., & Spanaki, C. (2017) · Biology · doi:10.3390/biology6010011 · Cited by 233 · see citing works

Mitochondrial metabolism and cancer therapeutic innovation

Du, H., Xu, T., Yu, S., Wu, S., & Zhang, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02311-x · Cited by 233 · see citing works

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Magaway, C., Kim, E., & Jacinto, E. (2019) · Cells · doi:10.3390/cells8121584 · Cited by 225 · see citing works

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

de la Cruz-López, K. G., Toledo-Guzmán, M. E., Sánchez, E. O., & Carrancá, A. G. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01373 · Cited by 215 · see citing works

mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment

Mafi, S., Mansoori, B., Taeb, S., Sadeghi, H., Abbasi, R., Cho, W. C. S., & Rostamzadeh, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.774103 · Cited by 225 · see citing works

Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

Tomasetti, M., Lee, W., Santarelli, L., & Neužil, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.153 · Cited by 216 · see citing works

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

Lien, E. C., Lyssiotis, C. A., & Cantley, L. C. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_3 · Cited by 211 · see citing works

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Wang, Y., He, J., Liao, M., Hu, M., Li, W., Ouyang, H., Wang, X., Ye, T., Zhang, Y., & Ouyang, L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.10.028 · Cited by 206 · see citing works

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

Davis, O. B., Shin, H. R., Lim, C.-Y., Wu, E. Y., Kukurugya, M., Maher, C. F., Perera, R. M., Ordonez, M. P., & Zoncu, R. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.11.016 · Cited by 200 · see citing works

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Fendt, S., Bell, E. L., Keibler, M. A., Davidson, S. M., Wirth, G. J., Fiske, B. P., Mayers, J. R., Schwab, M. G., Bellinger, G., Csibi, A., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0080 · Cited by 196 · see citing works

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

Solloway, M. J., Madjidi, A., Gu, C., Eastham-Anderson, J., Clarke, H. J., Kljavin, N. M., Zavala‐Solorio, J., Kates, L., Friedman, B. A., Brauer, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.034 · Cited by 186 · see citing works

mTOR signaling in stem and progenitor cells

Meng, D.-L., Frank, A., & Jewell, J. L. (2018) · Development · doi:10.1242/dev.152595 · Cited by 176 · see citing works

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

Meijer, A., Lorin, S., Blommaart, E., & Codogno, P. (2014) · Amino Acids · doi:10.1007/s00726-014-1765-4 · Cited by 175 · see citing works

Sirtuins in metabolism, DNA repair and cancer

Mei, Z., Zhang, X., Yi, J., Huang, J., He, J., & Tao, Y. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0461-5 · Cited by 191 · see citing works

Roles of Aldolase Family Genes in Human Cancers and Diseases

Chang, Y., Yang, Y., Tien, C., Yang, C., & Hsiao, M. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.003 · Cited by 186 · see citing works

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Carbonneau, M., M. Gagné, L., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., Secco, B., Vincent, E. E., Tumber, A., Hulea, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12700 · Cited by 180 · see citing works

The role of mitochondrial sirtuins in health and disease

Osborne, B., Bentley, N. L., Montgomery, M. K., & Turner, N. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.197 · Cited by 179 · see citing works

Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK

Moldogazieva, N. T., Mokhosoev, I. M., & Terentiev, A. A. (2020) · Cancers · doi:10.3390/cancers12040862 · Cited by 176 · see citing works

Cancer Systems Biology: a peek into the future of patient care?

Werner, H. M. J., Mills, G. B., & Ram, P. T. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.6 · Cited by 175 · see citing works

Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate–mediated mTOR Activation and Proline Hydroxylation

Ge, J., Cui, H., Xie, N., Banerjee, S., Guo, S., Dubey, S., Barnes, S., & Liu, G. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0238oc · Cited by 166 · see citing works

Altered cancer metabolism in mechanisms of immunotherapy resistance

Ramapriyan, R., Caetano, M. S., Barsoumian, H. B., Mafra, A. C. P., Zambalde, É. P., Menon, H., Tsouko, E., Welsh, J. W., & Cortez, M. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.004 · Cited by 171 · see citing works

Sirtuin Inhibitors as Anticancer Agents

Hu, J., Jing, H., & Lin, H. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.44 · Cited by 168 · see citing works

Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues

Varone, A., Xylas, J. F., Quinn, K. P., Pouli, D., Sridharan, G. V., McLaughlin-Drubin, M. E., Alonzo, C., Lee, K., Münger, K., & Georgakoudi, I. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2713 · Cited by 163 · see citing works

The emerging and diverse roles of sirtuins in cancer: a clinical perspective

Chen, W., Yuan, H., & Su, L. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s37750 · Cited by 163 · see citing works

Oncogenic regulation of tumor metabolic reprogramming

Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 159 · see citing works

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

Ho, L., Titus, A. S., Banerjee, K. K., George, S., Lin, W., Deota, S., Saha, A. K., Nakamura, K., Gut, P., Verdin, E. M., et al. (2013) · Aging · doi:10.18632/aging.100616 · Cited by 160 · see citing works

Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer

Kumar, S., & Lombard, D. B. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6213 · Cited by 158 · see citing works

Regulation of Glucose Metabolism – A Perspective From Cell Bioprocessing

Mulukutla, B. C., Yongky, A., Le, T. S., Mashek, D. G., & Hu, W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.04.012 · Cited by 160 · see citing works

Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

Dar, S. A., Chhina, J., Mert, İ., Chitale, D. A., Buekers, T., Kaur, H., Giri, S., Munkarah, A. R., & Rattan, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-09206-0 · Cited by 156 · see citing works

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer

Hu, Q., Qin, Y., Ji, S., Xu, W., Liu, W., Sun, Q., Zhang, Z., Liu, M., Ni, Q., Yu, X., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.024 · Cited by 158 · see citing works

Role of Metabolic Reprogramming in Epithelial–Mesenchymal Transition (EMT)

Kang, H., Kim, H., Lee, S., Youn, H., & Youn, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20082042 · Cited by 153 · see citing works

ATF4 and N‐Myc coordinate glutamine metabolism in MYCN ‐amplified neuroblastoma cells through ASCT2 activation

Ren, P., Yue, M., Xiao, D., Xiu, R., Gan, L., Liu, H., & Qing, G. (2014) · The Journal of Pathology · doi:10.1002/path.4429 · Cited by 156 · see citing works

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L., & Hall, M. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412047111 · Cited by 148 · see citing works

Increased glutamine catabolism mediates bone anabolism in response to WNT signaling

Karner, C. M., Esen, E., Okunade, A. L., Patterson, B. W., & Long, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci78470 · Cited by 153 · see citing works

Tumour-suppressive function of SIRT4 in human colorectal cancer

Miyo, M., Yamamoto, H., Konno, M., Colvin, H. S., Nishida, N., Koseki, J., Kawamoto, K., Ogawa, H., Hamabe, A., Uemura, M., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.226 · Cited by 151 · see citing works

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143 · see citing works

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

Yeo, H., Lyssiotis, C. A., Zhang, Y., Ying, H., Asara, J. M., Cantley, L. C., & Paik, J.-H. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.186 · Cited by 145 · see citing works

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

Ganesan, R., Hos, N. J., Gutiérrez, S., Fischer, J., Stepek, J. M., Daglidu, E., Krönke, M., & Robinson, N. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006227 · Cited by 142 · see citing works

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

Greene, K. S., Lukey, M. J., Wang, X., Blank, B. S., Druso, J. E., Lin, M.-C. J., Stalnecker, C. A., Zhang, C., Abril, Y. L. N., Erickson, J. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911954116 · Cited by 138 · see citing works

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Lang, A., Grether‐Beck, S., Singh, M., Kuck, F., Jakob, S., Kefalas, A., Altinoluk-Hambüchen, S., Graffmann, N., Schneider, M., Lindecke, A., et al. (2016) · Aging · doi:10.18632/aging.100905 · Cited by 138 · see citing works

Renal disease in tuberous sclerosis complex: pathogenesis and therapy

Lam, H. C., Siroky, B. J., & Henske, E. P. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0059-6 · Cited by 132 · see citing works

Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity

Dechant, R. C., Saad, S., Ibáñez, A. J., & Peter, M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.002 · Cited by 135 · see citing works

SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway

Fu, L., Dong, Q., He, J., Wang, X., Xing, J., Wang, E.-H., Qiu, X., & Li, Q. (2016) · Oncogene · doi:10.1038/onc.2016.425 · Cited by 135 · see citing works

The Roles of Mitochondrial SIRT4 in Cellular Metabolism

Min, Z., Gao, J., & Yu, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00783 · Cited by 135 · see citing works

Metabolic Characterization of a Sirt5 deficient mouse model

Yu, J., Sadhukhan, S., Noriega, L. G., Moullan, N., He, B., Weiss, R. S., Lin, H., Schoonjans, K., & Auwerx, J. H. (2013) · Scientific Reports · doi:10.1038/srep02806 · Cited by 130 · see citing works

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133 · see citing works

mTORC1 Stimulates Glutamine Metabolism

Foley, J. F. (2013) · Science Signaling · doi:10.1126/scisignal.2004338

Mechanistic target of rapamycin complex (mTORC)-glutamine axis in cancer: Mechanistic crosstalk, therapeutic resistance, and clinical opportunities

Das, S. R., Koman, I. E., & Nesher, E. (2026) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2026.08.003

mTORC1 Regulates Glutamine Metabolism

(2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2013-106 · Cited by 1 · see citing works

Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels

Jacinto, E., Moloughney, J. G., Kim, P. K., Vega-Cotto, N. M., Wu, C., Lynch, T. P., Zhang, S., Adlam, M. J., Guntaka, S., Chou, P., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-21

Biochemical characterization of mTORC1 regulation by glutamine metabolism

Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0