LaRusso, Nicholas F.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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An aged immune system drives senescence and ageing of solid organs

Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., LaRusso, N. F., & Gores, G. J. (2019) · Nature Reviews Gastroenterology & Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

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The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

Levy, C., Lymp, J., Angulo, P., Gores, G. J., Larusso, N., & Lindor, K. D. (2005) · Digestive Diseases and Sciences

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver Diseases and Immunity

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Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Marsee, A., Roos, F. J. M., Verstegen, M. M. A., Marsee, A., Roos, F., Verstegen, M., Clevers, H., Vallier, L., Takebe, T., Huch, M., et al. (2021) · Cell Stem Cell

3D Printing in Biomedical ResearchPancreatic function and diabetes

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Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis

Jaiswal, M., LaRusso, N. F., & Gores, G. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Nitric Oxide and Endothelin EffectsInflammatory mediators and NSAID effects

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Up-regulation of microRNA 506 leads to decreased Cl−/HCO3 − anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis

Banales, J. M., Sáez, E., Úriz, M., Sarvide, S., Urribarri, A. D., Splinter, P., Tietz Bogert, P. S., Bujanda, L., Prieto, J., Medina, J. F., et al. (2012) · Hepatology

Liver Diseases and ImmunityMicroRNA in disease regulation

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High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

Harnois, D. M., Angulo, P., Jorgensen, R. A., LaRusso, N. F., & Lindor, K. D. (2001) · American Journal of Gastroenterology

Liver Diseases and ImmunityInflammatory Bowel Disease

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Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Splinter, P. L., Trussoni, C. E., & LaRusso, N. F. (2014) · Hepatology

Liver Diseases and ImmunityTelomeres, Telomerase, and Senescence

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Extracellular Vesicles in Liver Pathobiology: Small Particles With Big Impact

Hirsova, P., Ibrahim, S. H., Verma, V. K., Morton, L. A., Shah, V. H., LaRusso, N. F., Gores, G. J., & Malhi, H. (2016) · Hepatology

Extracellular vesicles in diseaseCellular transport and secretion

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Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Trussoni, C. E., Tietz, P. S., Splinter, P. L., Mounajjed, T., Hagey, L. R., & LaRusso, N. F. (2016) · Hepatology

Liver Diseases and ImmunityGut microbiota and health

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Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F., & Rosen, A. (2001) · Journal of Clinical Investigation

Liver Diseases and ImmunityCell death mechanisms and regulation

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In primary sclerosing cholangitis, gallbladder polyps are frequently malignant

Buckles, D. C., Lindor, K. D., LaRusso, N. F., Petrovic, L. M., & Gores, G. J. (2002) · The American Journal of Gastroenterology

Cholangiocarcinoma and Gallbladder Cancer StudiesLiver Diseases and Immunity

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Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., et al. (2018) · Journal of Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

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Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y 12 purinergic receptors

Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S.-O., Splinter, P. L., Stroope, A. J., & LaRusso, N. F. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Genetic and Kidney Cyst DiseasesAdenosine and Purinergic Signaling

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis

Wiesner, R. H., LaRusso, N. F., Dozois, R. R., & Beaver, S. J. (1986) · Gastroenterology

Liver Diseases and ImmunityLiver Disease and Transplantation

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Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

Masyuk, A. I., Huang, B. Q., Radtke, B. N., Gajdos, G. B., Splinter, P. L., Masyuk, T. V., Gradilone, S. A., & LaRusso, N. F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Drug Transport and Resistance MechanismsGenetic and Kidney Cyst Diseases

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Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

Moncsek, A., Al‐Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., et al. (2018) · Hepatology

Liver Diseases and ImmunityLiver physiology and pathology

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Milder disease stage in patients with primary biliary cholangitis over a 44‐year period: A changing natural history

Murillo Perez, C. F., Goet, J. C., Lammers, W. J., Gulamhusein, A., van Buuren, H. R., Ponsioen, C. Y., Carbone, M., Mason, A., Corpechot, C., Invernizzi, P., et al. (2018) · Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

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Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: ileal pouch-anal anastomosis versus Brooke ileostomy

Kartheuser, A. H., Dozois, R. R., Larusso, N. F., Wiesner, R. H., Lstrup, D. M., & Schleck, C. D. (1996) · Mayo Clinic Proceedings

Inflammatory Bowel DiseaseColorectal Cancer Surgical Treatments

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Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis

Osman, K. T., Maselli, D. B., Idilman, I. S., Rowan, D. J., Viehman, J. K., Harmsen, W. S., Harnois, D. M., Carey, E. J., Gossard, A. A., LaRusso, N. F., et al. (2021) · Journal of Clinical Gastroenterology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

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Early cholangiocarcinoma detection with magnetic resonance imaging versus ultrasound in primary sclerosing cholangitis

Eaton, J. E., Welle, C. L., Bakhshi, Z., Sheedy, S. P., Idilman, I. S., Gores, G. J., Rosen, C. B., Heimbach, J. K., Taner, T., Harnois, D. M., et al. (2021) · Hepatology

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