Butovsky, Oleg

Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis

Butovsky, O. (2006) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 261

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

Lund, H., Pieber, M., Parsa, R., Han, J., Grommisch, D., Ewing, E., Kular, L., Needhamsen, M., Espinosa, A., Nilsson, E., et al. (2018) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 249

Retinal microglia initiate neuroinflammation in ocular autoimmunity

Okunuki, Y., Mukai, R., Nakao, T., Tabor, S. J., Butovsky, O., Dana, R., Ksander, B. R., & Connor, K. M. (2019) · Proceedings of the National Academy of Sciences

Ocular Diseases and Behçet’s SyndromeNeuroinflammation and Neurodegeneration Mechanisms

Cited by 216

P2Y12 expression and function in alternatively activated human microglia

Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic Signaling

Cited by 212

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 202

Early life stress perturbs the maturation of microglia in the developing hippocampus

Delpech, J.-C., Wei, L., Hao, J., Yu, X., Madore, C., Butovsky, O., & Kaffman, A. (2016) · Brain Behavior and Immunity

Neuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cited by 193

Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E. (2003) · Journal of Neuroimmunology

Spinal Cord Injury ResearchNerve injury and regeneration

Cited by 155

Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Hartmann, K., Sepulveda-Falla, D., Rose, I. V. L., Madore, C., Muth, C., Matschke, J., Butovsky, O., Liddelow, S., Glatzel, M., & Krasemann, S. (2019) · Acta Neuropathologica Communications

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 141

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

Margeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., et al. (2022) · Immunity

Glaucoma and retinal disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 130

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Yin, Z., Herron, S., Silveira, S., Kleemann, K., Gauthier, C., Mallah, D., Cheng, Y., Margeta, M. A., Pitts, K. M., Barry, J.-L., et al. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 120

Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts

Zrzavy, T., Machado‐Santos, J., Christine, S., Baumgartner, C., Weiner, H. L., Butovsky, O., & Lassmann, H. (2018) · Brain Pathology

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 118

Acute microglia ablation induces neurodegeneration in the somatosensory system

Rubino, S. J., Mayo, L., Wimmer, I., Siedler, V., Brunner, F., Hametner, S., Madi, A., Lanser, A., Moreira, T., Donnelly, D., et al. (2018) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 91

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., et al. (2025) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. (2020) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 77

Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner

Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., et al. (2024) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 70

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

Cox, L. M., Calcagno, N., Gauthier, C., Madore, C., Butovsky, O., & Weiner, H. L. (2022) · Microbiome

Neuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Cited by 53

Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4

Margeta, M. A., Letcher, S. M., Igo, R. P., Cooke Bailey, J. N., Pasquale, L. R., Haines, J. L., Butovsky, O., Wiggs, J. L., & for the NEIGHBORHOOD consortium (2020) · Investigative Opthalmology & Visual Science

Glaucoma and retinal disordersGlutathione Transferases and Polymorphisms

Cited by 51

Identification of a chronic non‐neurodegenerative microglia activation state in a mouse model of peroxisomal β‐oxidation deficiency

Verheijden, S., Beckers, L., Casazza, A., Butovsky, O., Mazzone, M., & Baes, M. (2015) · Glia

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 40

Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time

Muth, C., Schröck, K., Madore, C., Hartmann, K., Fanek, Z., Butovsky, O., Glatzel, M., & Krasemann, S. (2017) · Brain Pathology

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 23

Erratum: Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTGF-β signaling in diseases

Cited by 19