Cited by 155Spinal Cord Injury ResearchNerve injury and regenerationNeuroinflammation and Neurodegeneration Mechanisms

Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Bomstein, Yonit, Marder, Jonathan B., Vitner, Karen, Smirnov, Igor, Lisaey, Galit, Butovsky, Oleg, Fulga, Valentin, Yoles, Eti·2003·Journal of Neuroimmunology

Abstract

Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.

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Crossref · 10.1016/s0165-5728(03)00260-1

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Authors
Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E.
Affiliations
Weizmann Institute of Science (IL)
Corresponding author
Yoles, Eti
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2003-09
Volume
142
Issue
1-2
Pages
10-16
ISSN
0165-5728 (ISSN-L)
OpenAlex
W1986913334
Cited by
155
References
48
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 14
FWCI
6.80
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
spinal cord injury, macrophages, antigen-presenting cells, CD80, CD86, MHC class II, IL-1β, brain-derived neurotrophic factor, TNF-α, motor recovery, neuroprotection, axon regeneration
MeSH terms
Animals, Antigen-Presenting Cells, Behavior, Animal, Macrophage Activation, Macrophages, Male, Motor Activity, Skin, Spinal Cord Injuries, Injections, Intralesional, Cytokines, Rats, Sprague-Dawley, Rats

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