Santagata, Sandro

Copper induces cell death by targeting lipoylated TCA cycle proteins

Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., et al. (2022) · Science

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 4,932

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Tsvetkov, P., Detappe, A., Cai, K., Keys, H. R., Brune, Z., Ying, W., Thiru, P., Reidy, M., Kugener, G., Rossen, J., et al. (2019) · Nature Chemical Biology

Ubiquitin and proteasome pathwaysCell death mechanisms and regulation

Cited by 645

A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

Dahia, P. L. M., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., et al. (2005) · PLoS Genetics

Adrenal and Paraganglionic TumorsCancer, Hypoxia, and Metabolism

Cited by 443

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Scherz-Shouval, R., Santagata, S., Mendillo, M. L., Sholl, L. M., Ben-Aharon, I., Beck, A. H., Dias-Santagata, D., Koeva, M., Stemmer, S. M., Whitesell, L., et al. (2014) · Cell

Heat shock proteins researchTGF-β signaling in diseases

Cited by 386

The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination

Spanopoulou, E., Zaitseva, F., Wang, F.-H., Santagata, S., Baltimore, D., & Panayotou, G. (1996) · Cell

DNA Repair MechanismsT-cell and B-cell Immunology

Cited by 225

BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas

Brastianos, P. K., Twohy, E., Geyer, S., Gerstner, E. R., Kaufmann, T. J., Tabrizi, S., Kabat, B., Thierauf, J., Ruff, M. W., Bota, D. A., et al. (2023) · New England Journal of Medicine

Pituitary Gland Disorders and TreatmentsNeuroendocrine Tumor Research Advances

Cited by 146

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Tsvetkov, P., Mendillo, M. L., Zhao, J., Carette, J. E., Merrill, P. H., Cikes, D., Varadarajan, M., van Diemen, F. R., Penninger, J. M., Goldberg, A. L., et al. (2015) · eLife

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 83

Inhibiting HSP90 to treat cancer: a strategy in evolution

Whitesell, L., Santagata, S., & Lin, N. U. (2012) · Current Molecular Medicine

Heat shock proteins researchCancer Mechanisms and Therapy

Cited by 67

Definition of Minimal Domains of Interaction Within the Recombination-Activating Genes 1 and 2 Recombinase Complex

Aidinis, V., Dias, D. C., Gomez, C. A., Bhattacharyya, D., Spanopoulou, E., & Santagata, S. (2000) · The Journal of Immunology

DNA Repair MechanismsT-cell and B-cell Immunology

Cited by 47

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma

Rendo, V., Lee, E. Q., Bossi, C., Khuu, N., Rudek, M. A., Pal, S., Azazmeh, N., Rashid, R., Lin, J.-R., Cusick, M., et al. (2025) · Science Translational Medicine

Glioma Diagnosis and TreatmentCancer-related Molecular Pathways

Cited by 19