Mangelsdorf, David J.

Bile Acids as Hormones: The FXR-FGF15/19 Pathway

Kliewer, S. A., & Mangelsdorf, D. J. (2015) · Digestive Diseases

Drug Transport and Resistance MechanismsFibroblast Growth Factor Research

Cited by 424

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife

Fibroblast Growth Factor ResearchGenetics, Aging, and Longevity in Model Organisms

Cited by 420

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

Inagaki, T., Lin, V. Y., Goetz, R., Mohammadi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2008) · Cell Metabolism

Fibroblast Growth Factor ResearchGrowth Hormone and Insulin-like Growth Factors

Cited by 409

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism

Fibroblast Growth Factor ResearchParathyroid Disorders and Treatments

Cited by 403

FGF21 Regulates Sweet and Alcohol Preference

Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., et al. (2016) · Cell Metabolism

Fibroblast Growth Factor ResearchRegulation of Appetite and Obesity

Cited by 342

The energy balance model of obesity: beyond calories in, calories out

Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J., Mangelsdorf, D. J., O’Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., et al. (2022) · The American Journal of Clinical Nutrition

Regulation of Appetite and ObesityObesity, Physical Activity, Diet

Cited by 315

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism

Fibroblast Growth Factor ResearchParathyroid Disorders and Treatments

Cited by 286

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism

Fibroblast Growth Factor ResearchRegulation of Appetite and Obesity

Cited by 261

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Schumann, G., Liu, C., O’Reilly, P., Gao, H., Song, P., Xu, B., Ruggeri, B., Amin, N., Jia, T., Preis, S., et al. (2016) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 241

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine

Hypothalamic control of reproductive hormonesFibroblast Growth Factor Research

Cited by 230

Fibroblast growth factor 21: from pharmacology to physiology

Kliewer, S. A., & Mangelsdorf, D. J. (2010) · The American Journal of Clinical Nutrition

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 219

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H. (2002) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsRegulation of Appetite and Obesity

Cited by 181

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

Youm, Y.-H., Horvath, T. L., Mangelsdorf, D. J., Kliewer, S. A., & Dixit, V. D. (2016) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyFibroblast Growth Factor Research

Cited by 129

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D., & Koldamova, R. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 89