Cited by 286Fibroblast Growth Factor ResearchParathyroid Disorders and TreatmentsGDF15 and Related Biomarkers

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

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Owen, Bryn M., Mangelsdorf, David J., Kliewer, Steven A.·2015·Trends in Endocrinology & Metabolism

Abstract

Fibroblast growth factors (FGFs) 15/19 and 21 belong to a subfamily of FGFs that function as hormones. Produced in response to specific nutritional cues, they act on overlapping sets of cell surface receptors composed of classic FGF receptors in complex with βKlotho, and regulate metabolism and related processes during periods of fluctuating energy availability. Pharmacologically, both FGF15/19 and FGF21 cause weight loss and improve both insulin-sensitivity and lipid parameters in rodent and primate models of metabolic disease. Recently, FGF21 was shown to have similar effects in obese patients with type 2 diabetes. We discuss here emerging concepts in FGF15/19 and FGF21 tissue-specific actions and critically assess their putative role as candidate targets for treating metabolic disease.

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Authors
Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Mangelsdorf, David J.
  • Kliewer, Steven A.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2015-01
Volume
26
Issue
1
Pages
22-29
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2095244962
Cited by
286
References
97
Citations by year
2026: 6 · 2025: 11 · 2024: 17 · 2023: 21 · 2022: 34 · 2021: 29 · 2020: 18 · 2019: 21 · 2018: 35 · 2017: 40 · 2016: 32 · 2015: 22
FWCI
2.95
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067158)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
Keywords
FGF15/19, FGF21, fibroblast growth factor, metabolic hormones, β-Klotho, fibroblast growth factor receptor, tissue-specific signaling, insulin sensitivity, obesity, type 2 diabetes, weight loss, metabolic disease treatment, energy homeostasis
MeSH terms
Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Fibroblast Growth Factors, Humans, Liver, Metabolic Diseases, Obesity, Organ Specificity

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