Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
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Fibroblast growth factors (FGFs) 15/19 and 21 belong to a subfamily of FGFs that function as hormones. Produced in response to specific nutritional cues, they act on overlapping sets of cell surface receptors composed of classic FGF receptors in complex with βKlotho, and regulate metabolism and related processes during periods of fluctuating energy availability. Pharmacologically, both FGF15/19 and FGF21 cause weight loss and improve both insulin-sensitivity and lipid parameters in rodent and primate models of metabolic disease. Recently, FGF21 was shown to have similar effects in obese patients with type 2 diabetes. We discuss here emerging concepts in FGF15/19 and FGF21 tissue-specific actions and critically assess their putative role as candidate targets for treating metabolic disease.
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The expression levels and metabolic functions of FGF21 are dynamically impacted by nutritional status.
“The expression levels and metabolic functions of FGF21 are dynamically impacted by nutritional status (37, 102).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [102]
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- Authors
- Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Mangelsdorf, David J.
- Kliewer, Steven A.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 26
- Issue
- 1
- Pages
- 22-29
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4277911
- OpenAlex
- W2095244962
- Cited by
- 286
- References
- 97
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 17 · 2023: 21 · 2022: 34 · 2021: 29 · 2020: 18 · 2019: 21 · 2018: 35 · 2017: 40 · 2016: 32 · 2015: 22
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067158)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Keywords
- FGF15/19, FGF21, fibroblast growth factor, metabolic hormones, β-Klotho, fibroblast growth factor receptor, tissue-specific signaling, insulin sensitivity, obesity, type 2 diabetes, weight loss, metabolic disease treatment, energy homeostasis
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Fibroblast Growth Factors, Humans, Liver, Metabolic Diseases, Obesity, Organ Specificity
About these checks
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