Mangelsdorf, David J.

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell

Estrogen and related hormone effectsNuclear Receptors and Signaling

Cited by 6,964

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 2,714

Nuclear Receptors and Lipid Physiology: Opening the X-Files

Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 2,085

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism

Drug Transport and Resistance MechanismsFibroblast Growth Factor Research

Cited by 1,865

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M., & Thaller, C. (1992) · Cell

Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated Receptors

Cited by 1,780

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 1,504

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 1,487

Nuclear Receptors, RXR, and the Big Bang

Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell

Nuclear Receptors and SignalingRetinoids in leukemia and cellular processes

Cited by 1,200

Vitamin D Receptor As an Intestinal Bile Acid Sensor

Makishima, M., Lu, T. T., Xie, W., Whitfield, G. K., Domoto, H., Evans, R. M., Haussler, M. R., & Mangelsdorf, D. J. (2002) · Science

Vitamin D Research StudiesDrug Transport and Resistance Mechanisms

Cited by 1,176

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences

Drug Transport and Resistance MechanismsGut microbiota and health

Cited by 1,164

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 1,158

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell

Nuclear Receptors and SignalingEstrogen and related hormone effects

Cited by 1,015

FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 704

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology

Fibroblast Growth Factor ResearchParathyroid Disorders and Treatments

Cited by 700

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 683

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

Kir, S., Beddow, S. A., Samuel, V. T., Miller, P., Previs, S. F., Suino-Powell, K., Xu, H. E., Shulman, G. I., Kliewer, S. A., & Mangelsdorf, D. J. (2011) · Science

Fibroblast Growth Factor ResearchMetabolism, Diabetes, and Cancer

Cited by 637

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Markan, K. R., Naber, M. C., Ameka, M. K., Anderegg, M. D., Mangelsdorf, D. J., Kliewer, S. A., Mohammadi, M., & Potthoff, M. J. (2014) · Diabetes

Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic Diseases

Cited by 590

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine

Fibroblast Growth Factor ResearchCircadian rhythm and melatonin

Cited by 545

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 537

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism

Fibroblast Growth Factor ResearchRegulation of Appetite and Obesity

Cited by 523

International Union of Pharmacology. LXIII. Retinoid X receptors

Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews

Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated Receptors

Cited by 496

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development

Fibroblast Growth Factor ResearchGDF15 and Related Biomarkers

Cited by 442

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism

Fibroblast Growth Factor ResearchMetabolism, Diabetes, and Cancer

Cited by 431

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchBone Metabolism and Diseases

Cited by 426