Young, Deborah

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

Tomac, A., Lindqvist, E., Lin, L.-F. H., Ögren, S. O., Young, D., Hoffer, B. J., & Olson, L. (1995) · Nature

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 1,079

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet

Deep Brain Stimulation and Movement DisordersVirus-based gene therapy research

Cited by 1,067

VEGF links hippocampal activity with neurogenesis, learning and memory

Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics

Neurogenesis and neuroplasticity mechanismsAngiogenesis and VEGF in Cancer

Cited by 850

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

Connor, B., Young, D., Yan, Q., Faull, R. L. M., Synek, B., & Dragunow, M. (1997) · Molecular Brain Research

Alzheimer's disease research and treatmentsNerve injury and regeneration

Cited by 581

Long-term follow-up after gene therapy for canavan disease

Leone, P., Shera, D., McPhee, S. W. J., Francis, J. S., Kolodny, E. H., Bilaniuk, L. T., Wang, D.-J., Assadi, M., Goldfarb, O., Goldman, H. W., et al. (2012) · Science Translational Medicine

Virus-based gene therapy researchLysosomal Storage Disorders Research

Cited by 307

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes

Xu, R., Janson, C., Mastakov, M., Lawlor, P., Young, D., Mouravlev, A., Fitzsimons, H., Choi, K.-L., Ma, H., Dragunow, M., et al. (2001) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 174

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates

Lawlor, P. A., Bland, R. J., Mouravlev, A., Young, D., & During, M. J. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 161

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

Griffin, J. M., Fackelmeier, B., Fong, D. M., Mouravlev, A., Young, D., & O’Carroll, S. J. (2019) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 90

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

Lawlor, P. A., Bland, R. J., Das, P., Price, R. W., Holloway, V., Smithson, L., Dicker, B. L., During, M. J., Young, D., & Golde, T. E. (2007) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease

Klugmann, M., Leichtlein, C. B., Symes, C. W., Serikawa, T., Young, D., & During, M. J. (2005) · Molecular Therapy

Metabolism and Genetic DisordersVirus-based gene therapy research

Cited by 55

CCAAT-enhancer binding proteinα is expressed in activated microglial cells after brain injury

Walton, M., Saura, J., Young, D., MacGibbon, G., Hansen, W., Lawlor, P., Sirimanne, E., Gluckman, P., & Dragunow, M. (1998) · Molecular Brain Research

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 28