CCAAT-enhancer binding proteinα is expressed in activated microglial cells after brain injury
Abstract
Microglial cells play important roles in brain injury and repair and are implicated in diseases such as Alzheimer's disease, Creutzfeldt-Jacob disease, multiple sclerosis, the Aids Dementia Complex and stroke. Despite their importance in neuropathology, the underlying molecular basis for the activation of microglia after brain injury is not understood. We show, using RT-PCR, in situ hybridisation, immunocytochemistry, and electrophoretic mobility shift assay, that the CCAAT-enhancer binding protein alpha (C/EBP alpha), a sequence specific DNA-binding protein, is induced in microglial cells, but not astrocytes or neurons, after hypoxic-ischemic brain injury. These results suggest that C/EBP alpha might regulate gene expression and consequentially have a role in the activation and/or proliferation of microglia following brain injury.
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Normal adult microglia do not express C/EBP-α, but this transcription factor can be induced during inflammation.
“Normal adult microglia do not express C/EBP-α, but this transcription factor can be induced during inflammation38.”
From MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2011) · cites this paper as [38]
Cites
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Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
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Self-citation<i>miR‐124</i> Contributes to the functional maturity of microglia
Svahn, A. J., Giacomotto, J., Graeber, M. B., Rinkwitz, S., & Becker, T. S. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22328 · Cited by 42 · see citing works
- Authors
- Walton, M., Saura, J., Young, D., MacGibbon, G., Hansen, W., Lawlor, P., Sirimanne, E., Gluckman, P., & Dragunow, M.
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 61
- Issue
- 1-2
- Pages
- 11-22
- ISSN
- 0169-328X
- Cited by
- 27
- References
- 8
- Language
- en
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