Brain-derived neurotrophic factor is reduced in Alzheimer's disease
Abstract
Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has been observed in human post-mortem Alzheimer's disease hippocampi. To further investigate this observation, we examined whether the alteration in BDNF expression also occurred at the protein level in human post-mortem Alzheimer's disease hippocampi and temporal cortices using immunohistochemical techniques. We observed a reduction in the intensity and number of BDNF-immunoreactive cell bodies within both the Alzheimer's disease hippocampus and temporal cortex when compared to normal tissue. These results support and extend previous findings that BDNF mRNA is reduced in the human Alzheimer's disease hippocampus and temporal cortex, and suggest that a loss of BDNF may contribute to the progressive atrophy of neurons in Alzheimer's disease.
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Amounts of BDNF protein are reduced in the entorhinal cortex and hippocampus in Alzheimer's disease.
“Furthermore, amounts of BDNF protein are reduced in the entorhinal cortex and hippocampus in Alzheimer’s disease7–9.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [8]
Concentrations of BDNF decline in the entorhinal cortex and hippocampus in Alzheimer's disease.
“Notably, the concentrations of BDNF decline in the entorhinal cortex and hippocampus in Alzheimer’s disease7–9”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [8]
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- Authors
- Connor, B., Young, D., Yan, Q., Faull, R. L. M., Synek, B., & Dragunow, M.
- Affiliations
- University of Auckland (NZ)
- Amgen (United States) (US)
- Corresponding author
- Dragunow, M
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 49
- Issue
- 1-2
- Pages
- 71-81
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W2066110504
- Semantic Scholar
- a385238b46b7b02bb47d4a84981c14b8629f1782
- Cited by
- 581
- References
- 82
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 20 · 2023: 26 · 2022: 18 · 2021: 23 · 2020: 31 · 2019: 28 · 2018: 24 · 2017: 23 · 2016: 33 · 2015: 36 · 2014: 28 · 2013: 35 · 2012: 25
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- brain-derived neurotrophic factor, Alzheimer's disease, hippocampus, temporal cortex, neuronal atrophy, postmortem brain
- MeSH terms
- Adult, Aged, Alzheimer Disease, Brain, Down Syndrome, Female, Hippocampus, Humans, Immunohistochemistry, Male, Middle Aged, Postmortem Changes, Reference Values, RNA, Messenger, Temporal Lobe, Transcription, Genetic, Dentate Gyrus, Brain-Derived Neurotrophic Factor
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