Cited by 581Alzheimer's disease research and treatmentsNerve injury and regenerationDementia and Cognitive Impairment Research

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

Connor, B, Young, D, Yan, Q, Faull, R.L.M, Synek, B, Dragunow, M·1997·Molecular Brain Research

Abstract

Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has been observed in human post-mortem Alzheimer's disease hippocampi. To further investigate this observation, we examined whether the alteration in BDNF expression also occurred at the protein level in human post-mortem Alzheimer's disease hippocampi and temporal cortices using immunohistochemical techniques. We observed a reduction in the intensity and number of BDNF-immunoreactive cell bodies within both the Alzheimer's disease hippocampus and temporal cortex when compared to normal tissue. These results support and extend previous findings that BDNF mRNA is reduced in the human Alzheimer's disease hippocampus and temporal cortex, and suggest that a loss of BDNF may contribute to the progressive atrophy of neurons in Alzheimer's disease.

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Crossref · 10.1016/s0169-328x(97)00125-3

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Authors
Connor, B., Young, D., Yan, Q., Faull, R. L. M., Synek, B., & Dragunow, M.
Affiliations
  • University of Auckland (NZ)
  • Amgen (United States) (US)
Corresponding author
Dragunow, M
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
1997-10
Volume
49
Issue
1-2
Pages
71-81
ISSN
0169-328X (ISSN-L)
OpenAlex
W2066110504
Cited by
581
References
82
Citations by year
2026: 7 · 2025: 20 · 2024: 20 · 2023: 26 · 2022: 18 · 2021: 23 · 2020: 31 · 2019: 28 · 2018: 24 · 2017: 23 · 2016: 33 · 2015: 36 · 2014: 28 · 2013: 35 · 2012: 25
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
brain-derived neurotrophic factor, Alzheimer's disease, hippocampus, temporal cortex, neuronal atrophy, postmortem brain
MeSH terms
Adult, Aged, Alzheimer Disease, Brain, Down Syndrome, Female, Hippocampus, Humans, Immunohistochemistry, Male, Middle Aged, Postmortem Changes, Reference Values, RNA, Messenger, Temporal Lobe, Transcription, Genetic, Dentate Gyrus, Brain-Derived Neurotrophic Factor

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