Gurkar, Aditi U.

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,584

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., et al. (2020) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 331

Nuclear genomic instability and aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 275

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 155

Spatial mapping of cellular senescence: emerging challenges and opportunities

Gurkar, A. U., Gerencser, A. A., Mora, A. L., Nelson, A. C., Zhang, A. R., Lagnado, A. B., Enninful, A., Benz, C., Furman, D., Beaulieu, D., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 141

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., et al. (2020) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

Hiraki, M., Hwang, S.-Y., Cao, S., Ramadhar, T. R., Byun, S., Yoon, K. W., Lee, J. H., Chu, K., Gurkar, A. U., Kolev, V., et al. (2015) · Chemistry & Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 81

Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Hamsanathan, S., Anthonymuthu, T., Han, S., Shinglot, H., Siefken, E., Sims, A., Sen, P., Pepper, H. L., Snyder, N. W., Bayir, H., et al. (2022) · Science Advances

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 30

Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60

Hamsanathan, S., Anthonymuthu, T., Mullett, S. J., Wendell, S. G., Han, S., Shinglot, H., Siefken, E., Sims, A., Sen, P., Pepper, H. L., et al. (2021) · Science Advances

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 30

Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease

Cuevas, R. A., Hortells, L., Chu, C. C., Wong, R., Crane, A., Boufford, C. K., Regan, C., Moorhead, W. J., Bashline, M. J., Parwal, A., et al. (2025) · Circulation Research

Cardiac Valve Diseases and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 11