Manalis, Scott R.

Weighing of biomolecules, single cells and single nanoparticles in fluid

Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature

Mechanical and Optical ResonatorsAcoustic Wave Resonator Technologies

Cited by 1,213

Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

Hosios, A. M., Hecht, V. C., Danai, L. V., Johnson, M. O., Rathmell, J. C., Steinhauser, M. L., Manalis, S. R., & Vander Heiden, M. G. (2016) · Developmental Cell

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 641

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Raghavan, S., Winter, P. S., Navia, A. W., Williams, H. L., DenAdel, A., Lowder, K. E., Galvez-Reyes, J., Kalekar, R. L., Mulugeta, N., Kapner, K. S., et al. (2021) · Cell

Pancreatic and Hepatic Oncology ResearchSingle-cell and spatial transcriptomics

Cited by 592

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Neurohr, G. E., Terry, R. L., Lengefeld, J., Bonney, M., Brittingham, G. P., Moretto, F., Miettinen, T. P., Vaites, L. P., Soares, L. M., Paulo, J. A., et al. (2019) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 518

Using buoyant mass to measure the growth of single cells

Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods

Microfluidic and Bio-sensing TechnologiesAcoustic Wave Resonator Technologies

Cited by 394

Measurement of mass, density, and volume during the cell cycle of yeast

Bryan, A. K., Goranov, A., Amon, A., & Manalis, S. R. (2010) · Proceedings of the National Academy of Sciences

Microfluidic and Bio-sensing TechnologiesFungal and yeast genetics research

Cited by 278

High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays

Cermak, N., Olcum, S., Delgado, F. F., Wasserman, S. C., Payer, K. R., A Murakami, M., Knudsen, S. M., Kimmerling, R. J., Stevens, M. M., Kikuchi, Y., et al. (2016) · Nature Biotechnology

Microfluidic and Bio-sensing TechnologiesMicrofluidic and Capillary Electrophoresis Applications

Cited by 227

Direct observation of mammalian cell growth and size regulation

Son, S., Tzur, A., Weng, Y., Jorgensen, P., Kim, J., Kirschner, M. W., & Manalis, S. R. (2012) · Nature Methods

Gene Regulatory Network AnalysisCell Image Analysis Techniques

Cited by 220

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

Gimpel, A. L., Katsikis, G., Sha, S., Maloney, A. J., Hong, M. S., Nguyen, T. N. T., Wolfrum, J., Springs, S. L., Sinskey, A. J., Manalis, S. R., et al. (2021) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchProtein purification and stability

Cited by 185

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate

Stevens, M. M., Maire, C. L., Chou, N., Murakami, M. A., Knoff, D. S., Kikuchi, Y., Kimmerling, R. J., Liu, H., Haidar, S., Calistri, N. L., et al. (2016) · Nature Biotechnology

Microfluidic and Bio-sensing TechnologiesCancer Cells and Metastasis

Cited by 106

Cellular pathways of recombinant adeno-associated virus production for gene therapy

Sha, S., Maloney, A. J., Katsikis, G., Nguyen, T. N. T., Neufeld, C., Wolfrum, J., Barone, P. W., Springs, S. L., Manalis, S. R., Sinskey, A. J., et al. (2021) · Biotechnology Advances

Virus-based gene therapy researchViral Infectious Diseases and Gene Expression in Insects

Cited by 67

Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size

Byun, S., Hecht, V. C., & Manalis, S. R. (2015) · Biophysical Journal

Cellular Mechanics and InteractionsMicrofluidic and Bio-sensing Technologies

Cited by 34

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

Wu, W., Lam, A. R., Suarez, K., Smith, G. N., Duquette, S. M., Yu, J., Mankus, D., Bisher, M., Lytton-Jean, A., Manalis, S. R., et al. (2025) · Current Biology

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 9

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

Wu, W., Lam, A. R., Suarez, K., Smith, G. N., Duquette, S. M., Yu, J., Mankus, D., Bisher, M., Lytton-Jean, A., Manalis, S. R., et al. (2024) · Current Biology

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 9