Downward, Julian

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 7,774

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D. (1984) · Nature

HER2/EGFR in Cancer ResearchCancer-related Molecular Pathways

Cited by 2,516

Phosphatidylinositol-3-OH kinase direct target of Ras

Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 1,954

Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis

Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell

Hippo pathway signaling and YAP/TAZPI3K/AKT/mTOR signaling in cancer

Cited by 843

Lung adenocarcinoma promotion by air pollutants

Hill, W., Lim, E. L., Weeden, C. E., Lee, C., Augustine, M., Chen, K., Kuan, F.-C., Marongiu, F., Evans, E. J., Moore, D. A., et al. (2023) · Nature

Air Quality and Health ImpactsCarcinogens and Genotoxicity Assessment

Cited by 808

RAS Interaction with PI3K: More Than Just Another Effector Pathway

Castellano, E., & Downward, J. (2011) · Genes & Cancer

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 762

Autophosphorylation sites on the epidermal growth factor receptor

Downward, J., Parker, P., & Waterfield, M. D. (1984) · Nature

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 704

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D. S., Tabrizi, S. J., Wood, N. W., et al. (2009) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 682

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

Coelho, M. A., de Carné Trécesson, S., Rana, S., Zecchin, D., Moore, C., Molina-Arcas, M., East, P., Spencer-Dene, B., Nye, E., Barnouin, K., et al. (2017) · Immunity

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 653

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Miess, H., Dankworth, B., Gouw, A. M., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, D. W., et al. (2018) · Oncogene

Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism

Cited by 361

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A. S. Y., Miljan, E. A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E., et al. (2008) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 316

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

Marte, B. M., Rodriguez-Viciana, P., Wennström, S., Warne, P. H., & Downward, J. (1997) · Current Biology

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 223

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Molina-Arcas, M., Moore, C., Rana, S., van Maldegem, F., Mugarza, E., Romero-Clavijo, P., Herbert, E., Horswell, S., Li, L.-S., Janes, M. R., et al. (2019) · Science Translational Medicine

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 203

Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in KRAS -Mutant Lung Cancer

Molina-Arcas, M., Hancock, D. C., Sheridan, C., Kumar, M. S., & Downward, J. (2013) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 157

Exploiting the therapeutic implications of KRAS inhibition on tumor immunity

Molina-Arcas, M., & Downward, J. (2024) · Cancer Cell

Cancer Immunotherapy and BiomarkersProtein Kinase Regulation and GTPase Signaling

Cited by 152

Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., et al. (2005) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 108

Targeting RAS and PI3K in lung cancer

Downward, J. (2008) · Nature Medicine

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 80

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

Ocasio, C. A., Baggelaar, M. P., Sipthorp, J., Losada de la Lastra, A., Tavares, M., Volarić, J., Soudy, C., Storck, E. M., Houghton, J. W., Palma-Duran, S. A., et al. (2024) · Nature Biotechnology

Click Chemistry and ApplicationsLipid metabolism and biosynthesis

Cited by 56

SnapShot: Class I PI3K Isoform Signaling

Fritsch, R., & Downward, J. (2013) · Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 42

Mutant KRAS at the heart of tumor immune evasion

van Maldegem, F., & Downward, J. (2020) · Immunity

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 32

High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS

Ismail, M., Davies, G., Sproat, G., Monteverde, T., Tart, J., Acebrón-García-de-Eulate, M., Gohlke, A., Hancock, D., Adhikari, S., Stefanovic-Barrett, S., et al. (2024) · SLAS Discovery

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 6

Abstract 4029: Combination of KRASG12C(ON) and SHP2 inhibitors overcomes adaptive resistance and enhances anti-tumor immunity

Anastasiou, P., Mugarza, E., Boumelha, J., Rana, S., Moore, C., Molina-Arcas, M., & Downward, J. (2022) · Cancer Research

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 3

Targeting a KRAS neoantigen peptide vaccine to DNGR-1+ dendritic cells

Ambler, R., Von Karstedt, S., & Downward, J. (2020) · European Journal of Cancer

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 1