Sakamoto, Kei

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 1,181

Anti-inflammatory effects of metformin irrespective of diabetes status

Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., et al. (2016) · Circulation Research

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 704

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

McManus, E. J., Sakamoto, K., Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R., & Alessi, D. R. (2005) · The EMBO Journal

Wnt/β-catenin signaling in development and cancerMetabolism, Diabetes, and Cancer

Cited by 594

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

Sakamoto, K., & Holman, G. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism

Cellular transport and secretionMetabolism, Diabetes, and Cancer

Cited by 481

Molecular mechanism of action of metformin: old or new insights?

Rena, G., Pearson, E. R., & Sakamoto, K. (2013) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 479

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Huang, X., Wullschleger, S., Shpiro, N., McGuire, V. A., Sakamoto, K., Woods, Y. L., Mcburnie, W., Fleming, S., & Alessi, D. R. (2008) · Biochemical Journal

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 396

Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F., & Goodyear, L. J. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 315

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H., & Sakamoto, K. (2018) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 313

Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects with Type 2 Diabetes

Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., et al. (2007) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 304

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 299

Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

Dimopoulos, N., Watson, M., Sakamoto, K., & Hundal, H. S. (2006) · Biochemical Journal

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 247

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., & Kahn, C. R. (2002) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 207

Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., van Diepen, J. A., Voshol, P. J., Jensen, J., & Sakamoto, K. (2010) · Cell Metabolism

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 196

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., et al. (2018) · Nature Cell Biology

Pancreatic and Hepatic Oncology ResearchCancer, Lipids, and Metabolism

Cited by 192

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., et al. (2015) · Cellular Signalling

Metabolism, Diabetes, and CancerAdvanced Proteomics Techniques and Applications

Cited by 167

Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle

Hunter, R. W., Treebak, J. T., Wojtaszewski, J. F. P., & Sakamoto, K. (2011) · Diabetes

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 151

Important role for AMPKαl in limiting skeletal muscle cell hypertrophy

Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, K., Foretz, M., & Viollet, B. (2009) · The FASEB Journal

Muscle Physiology and DisordersMetabolism, Diabetes, and Cancer

Cited by 133

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., et al. (2012) · Biochemical Journal

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 131

The Muscle-specific Protein Phosphatase PP1G/RGL(GM) Is Essential for Activation of Glycogen Synthase by Exercise

Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats, C., Hirshman, M. F., Dufresne, S. D., Sakamoto, K., Vilardo, P. G., Steele, M., Kim, J.-H., et al. (2001) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 106

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase

Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., et al. (2011) · Hepatology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 86

Beyond AICA riboside: In search of new specific AMP‐activated protein kinase activators

Guigas, B., Sakamoto, K., Taleux, N., Reyna, S. M., Musi, N., Viollet, B., & Hue, L. (2009) · IUBMB Life

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 86

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K., & Hundal, H. S. (2011) · Biochemical Journal

NF-κB Signaling PathwaysMetabolism, Diabetes, and Cancer

Cited by 78

Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle

Sakamoto, K., Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F., & Goodyear, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 63

Structural basis for the recruitment of glycogen synthase by glycogenin

Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., et al. (2014) · Proceedings of the National Academy of Sciences

Glycogen Storage Diseases and MyoclonusMetabolism, Diabetes, and Cancer

Cited by 57