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“What's in a structure?” The story of biguanides

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Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2

Tian, R., Li, R., Liu, Y., Liu, J., Pan, T., Zhang, R., Liu, B., Chen, E., Tang, Y.-Q., & Qu, H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.009 · Cited by 67 · see citing works

Cardiovascular impact of drugs used in the treatment of diabetes

Triggle, C. R., & Ding, H. (2014) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622314546125 · Cited by 66 · see citing works

Traumatic brain injury decreases AMP ‐activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome

Hill, J. L., Kobori, N., Zhao, J., Rozas, N. S., Hylin, M. J., Moore, A. N., & Dash, P. K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13726 · Cited by 67 · see citing works

In vitro and in vivo hypoglycemic effects of cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside, an anthocyanin isolated from purple-fleshed sweet potato

Jang, H., Kim, H., Kim, S., Kim, S., Kim, J.-B., & Lee, Y. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.08.010 · Cited by 67 · see citing works

Use of metformin and risk of kidney cancer in patients with type 2 diabetes

Tseng, C. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.09.027 · Cited by 66 · see citing works

Metformin reduces saturated fatty acid-induced lipid accumulation and inflammatory response by restoration of autophagic flux in endothelial cells

Kim, H.-S., Ren, G., Kim, T., Bhatnagar, S., Yang, Q., Bahk, Y. Y., & Kim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70347-w · Cited by 66 · see citing works

Common medications used by patients with type 2 diabetes mellitus: what are their effects on the lipid profile?

Rosenblit, P. D. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0412-7 · Cited by 66 · see citing works

Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool?

Florez, J. C. (2017) · Diabetologia · doi:10.1007/s00125-017-4227-1 · Cited by 70 · see citing works

Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes

Rotroff, D. M., Yee, S. W., Zhou, K., Marvel, S. W., Shah, H., Jack, J. R., Havener, T. M., Hedderson, M. M., Kubo, M., Herman, M. A., et al. (2018) · Diabetes · doi:10.2337/db17-1164 · Cited by 62 · see citing works

Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring

Salomäki, H., Heinäniemi, M., Vähätalo, L. H., Ailanen, L., Eerola, K., Ruohonen, S. T., Pesonen, U., & Koulu, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115778 · Cited by 63 · see citing works

Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury

Dai, J., Liu, M., Ai, Q., Lin, L., Wu, K., Deng, X., Jing, Y., Jia, M., Wan, J., & Zhang, L. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.03.013 · Cited by 63 · see citing works

Isorhamnetin Reduces Glucose Level, Inflammation, and Oxidative Stress in High-Fat Diet/Streptozotocin Diabetic Mice Model

Alqudah, A. M., Qnais, E. Y., Wedyan, M. A., Altaber, S., Bseiso, Y., Oqal, M. K., Abudalo, R. A., Alrosan, K., Alrosan, A. Z., Melhim, S. B., et al. (2023) · Molecules · doi:10.3390/molecules28020502 · Cited by 62 · see citing works

Neuropharmacological Actions of Metformin in Stroke

Jia, J., Cheng, J. G., Ni, J., & Zhen, X. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150205143555 · Cited by 62 · see citing works

Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice

Xiao, N., Lou, M., Lu, Y., Yang, L., Liu, Q., Liu, B., Qi, L., & Li, P. (2017) · Diabetologia · doi:10.1007/s00125-017-4238-y · Cited by 62 · see citing works

NK Cell Metabolism and TGFβ – Implications for Immunotherapy

Slattery, K., & Gardiner, C. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02915 · Cited by 59 · see citing works

Pharmacology of metformin – An update

Glossmann, H. H., & Lutz, O. M. D. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172782 · Cited by 61 · see citing works

Serendipity in Cancer Drug Discovery: Rational or Coincidence?

Prasad, S., Gupta, S. C., & Aggarwal, B. B. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.03.004 · Cited by 59 · see citing works

Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats

Ghasemnejad‐Berenji, M., Ghazi‐Khansari, M., Yazdani, I., Nobakht, M., Abdollahi, M. R., Ghasemnejad‐Berenji, H., Ansari, J. M., Pashapour, S., & Dehpour, A. R. (2017) · Andrologia · doi:10.1111/and.12846 · Cited by 59 · see citing works

Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advancedin vitrotesting

Koepsell, H. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1915284 · Cited by 58 · see citing works

Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response

He, B., Zhang, Z., Huang, Z., Duan, X., Wang, Y., Cao, J., Li, L., He, K., Nice, E. C., He, W., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115444 · Cited by 58 · see citing works

The role of fibroblast growth factor 21 in diabetes and its complications: A review from clinical perspective

Liu, J., Foo, J. P., Liu, S., & Lim, S. C. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.02.032 · Cited by 58 · see citing works

Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer’s Disease

Ahmad, W., & Ebert, P. R. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0085-y · Cited by 57 · see citing works

New Insight into the Mechanisms of the Anti-hyperglycemic Action of Metformin

Gruszka, A. (2015) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2016/23354 · Cited by 7 · see citing works

Moleculair werkingsmechanisme van metformine: oude of nieuwe inzichten?

Rena, G., Pearson, E. R., & Sakamoto, K. (2013) · Nederlands Tijdschrift voor Diabetologie · doi:10.1007/s12467-013-0061-3

Metformin as an activator of AMP-activated protein kinase. Known and new mechanisms of action

Mkrtumyan, A. M., Маркова, Т. Н., Ovchinnikova, M. A., Ivanova, I. A., & Kuzmenko, K. V. (2023) · Diabetes Mellitus · doi:10.14341/dm13044 · Cited by 6 · see citing works

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287 · see citing works

AMP-kinase is the Main Target of Metformin in Regulating Type 2 Diabetes

Haque, R., & Rajia, S. (2023) · Book Publisher International (a part of SCIENCEDOMAIN International) · doi:10.9734/bpi/rhdhr/v2/9366f