Desprez, Pierre-Yves

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 5,206

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,730

Inflammatory networks during cellular senescence: causes and consequences.

Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,354

Senescent cells as a source of inflammatory factors for tumor progression

Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 636

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 506

Role of immune cells in the removal of deleterious senescent cells

Kale, A., Sharma, A., Stolzing, A., Desprez, P.-Y., & Campisi, J. (2020) · Immunity & Ageing

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 351

Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts

Laberge, R.-M., Awad, P., Campisi, J., & Desprez, P.-Y. (2012) · Cancer Microenvironment

Telomeres, Telomerase, and SenescenceTGF-β signaling in diseases

Cited by 255

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 229

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

McAllister, S. D., Murase, R., Christian, R. T., Lau, D., Zielinski, A. J., Allison, J., Almanza, C., Pakdel, A., Lee, J., Limbad, C., et al. (2011) · Breast Cancer Research and Treatment

Cannabis and Cannabinoid ResearchCancer Cells and Metastasis

Cited by 229

Context-dependent effects of cellular senescence in cancer development.

Lecot, P., Alimirah, F., Desprez, P.-Y., Campisi, J., & Wiley, C. (2016) · British Journal of Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 183

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

Perrott, K. M., Wiley, C. D., Desprez, P.-Y., & Campisi, J. (2017) · GeroScience

Flavonoids in Medical ResearchTelomeres, Telomerase, and Senescence

Cited by 163

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

Wiley, C. D., Liu, S., Limbad, C., Zawadzka, A. M., Beck, J., Demaria, M., Artwood, R., Alimirah, F., Lopez-Dominguez, J.-A., Kuehnemann, C., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 137

Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling

Alimirah, F., Pulido, T., Valdovinos, A., Alptekin, S., Chang, E., Jones, E., Diaz, D. A., Flores, J., Velarde, M. C., Demaria, M., et al. (2020) · Cancer Research

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 128

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Wiley, C. D., Schaum, N., Alimirah, F., Lopez-Dominguez, J. A., Orjalo, A. V., Scott, G., Desprez, P.-Y., Benz, C., Davalos, A. R., & Campisi, J. (2018) · Scientific Reports

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 124

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells

Liu, S., Uppal, H., Demaria, M., Desprez, P.-Y., Campisi, J., & Kapahi, P. (2015) · Scientific Reports

Telomeres, Telomerase, and SenescenceCancer, Lipids, and Metabolism

Cited by 124

Systemic induction of senescence in young mice after single heterochronic blood exchange

Jeon, O. H., Mehdipour, M., Gil, T.-H., Kang, M., Aguirre, N. W., Robinson, Z. R., Kato, C., Etienne, J., Lee, H. G., Alimirah, F., et al. (2022) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence.

López-Domínguez, J. A., Rodríguez-López, S., Ahumada-Castro, U., Desprez, P.-Y., Konovalenko, M., Laberge, R.-M., Cárdenas, C., Villalba, J. M., & Campisi, J. (2021) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 83

Quantitative Proteomic Analysis of the Senescence-Associated Secretory Phenotype by Data-Independent Acquisition.

Neri, F., Basisty, N., Desprez, P., Campisi, J., & Schilling, B. (2021) · Current Protocols

Telomeres, Telomerase, and SenescenceAdvanced Proteomics Techniques and Applications

Cited by 48

Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

Zou, Y., Zhang, N., Ellerby, L. M., Davalos, A. R., Zeng, X., Campisi, J., & Desprez, P.-Y. (2012) · Biochemical and Biophysical Research Communications

Effects of Radiation ExposurePluripotent Stem Cells Research

Cited by 41

A Fully-Automated Senescence Test (FAST) for the high-throughput quantification of senescence-associated markers

Neri, F., Takajjart, S. N., Lerner, C. A., Desprez, P.-Y., Schilling, B., Campisi, J., & Gerencser, A. A. (2024) · GeroScience

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 17