Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

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A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

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p53 in senescence – it's a marathon, not a sprint

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Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies

Khalil, R., Diab‐Assaf, M., & Lemaı̂tre, J.-M. (2023) · Cells · doi:10.3390/cells12060915 · Cited by 66 · see citing works

Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

Chae, J., Jang, H., Son, C., Park, C., Choi, H., Jin, S., Lee, H., Lee, H., Ryu, J., Kim, N., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00457-4 · Cited by 63 · see citing works

p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload

Liu, X., Burke, R. M., Lighthouse, J. K., Baker, C. D., Dirkx, R. A., Kang, B., Chakraborty, Y., Mickelsen, D. M., Twardowski, J. J., Mello, S. S., et al. (2023) · Circulation Research · doi:10.1161/circresaha.121.320324 · Cited by 63 · see citing works

Rapamycin, proliferation and geroconversion to senescence

Blagosklonny, M. V. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1554781 · Cited by 61 · see citing works

Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

Thoppil, H., & Riabowol, K. T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00367 · Cited by 59 · see citing works

Senescence under appraisal: hopes and challenges revisited

Davan-Wetton, C. S. A., Pessolano, E., Perretti, M., & Montero‐Melendez, T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03746-x · Cited by 59 · see citing works

BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis

Bharti, V., Watkins, R., Kumar, A., Shattuck-Brandt, R. L., Mossing, A., Mittra, A., Shen, C., Tsung, A., Davies, A. E., Hanel, W. G., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111826 · Cited by 57 · see citing works

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Liu, Y., Dou, Y., Sun, X., & Yang, Q. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.02.003 · Cited by 57 · see citing works

Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells

Fan, X., He, Y., Wu, G., Chen, H., Cheng, X., Zhan, Y., An, C., Chen, T., & Wang, X. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119411 · Cited by 51 · see citing works

Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition

Scott, G. K., Yau, C. S. F., Becker, B. C., Khateeb, S. I., Mahoney, S. A., Jensen, M. B., Hann, B. C., Cowen, B. J., Pegan, S. D., & Benz, C. C. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-1323 · Cited by 47 · see citing works

Senescent cells limit p53 activity via multiple mechanisms to remain viable

Sturmlechner, I., Sine, C. C., Jeganathan, K. B., Zhang, C., Velasco, R. O. F., Baker, D. J., Li, H., & van Deursen, J. M. (2022) · Nature Communications · doi:10.1038/s41467-022-31239-x · Cited by 45 · see citing works

Cellular senescence in neuroinflammatory disease: new therapies for old cells?

Nelke, C., Schroeter, C. B., Pawlitzki, M., Meuth, S. G., & Ruck, T. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.07.003 · Cited by 45 · see citing works

A tale of the good and bad: Cell senescence in bone homeostasis and disease

Liu, X., & Wan, M. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.03.005 · Cited by 44 · see citing works

Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers

Karaayvaz, M., Silberman, R. E., Langenbucher, A., Saladi, S. V., Ross, K. N., Zarcaro, E., Desmond, A. J., Yıldırım, M., Vivekanandan, V., Ravichandran, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay2611 · Cited by 41 · see citing works

Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence

Ahumada-Castro, U., Puebla-Huerta, A., Cuevas-Espinoza, V., Lovy, A., & Cárdenas, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119099 · Cited by 43 · see citing works

Senescent cells: A therapeutic target for osteoporosis

Wang, T., Huang, S., & He, C. (2022) · Cell Proliferation · doi:10.1111/cpr.13323 · Cited by 43 · see citing works

Advances and challenges in geroscience research: An update

Yabluchanskiy, A., Ungvari, Z. I., Csiszár, A., & Tarantini, S. (2018) · Physiology International · doi:10.1556/2060.105.2018.4.32 · Cited by 42 · see citing works

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina, E., Shaposhnikov, M. V., & Moskalev, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124484 · Cited by 42 · see citing works

Senotherapeutics and Their Molecular Mechanism for Improving Aging

Park, J., & Shin, D. W. (2022) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2022.114 · Cited by 43 · see citing works

PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53

Rubin de Celis, M. F., Garcia-Martin, R., Syed, I., Lee, J., Aguayo-Mazzucato, C., Bonner-Weir, S., & Kahn, B. B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2206923119 · Cited by 39 · see citing works

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

Miller, K. N., Li, B., Pierce-Hoffman, H. R., Patel, S., Lei, X., Rajesh, A., Teneche, M. G., Havas, A. P., Gandhi, A., Macip, C. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57229-3 · Cited by 41 · see citing works

Anti-aging: senolytics or gerostatics (unconventional view)

Blagosklonny, M. V. (2021) · Oncotarget · doi:10.18632/oncotarget.28049 · Cited by 38 · see citing works

P53 in the impaired lungs

Uddin, M. A., & Barabutis, N. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102952 · Cited by 35 · see citing works

p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)

Milani, D., Caruso, L., Zauli, E., Owaifeer, A. M. A., Secchiero, P., Zauli, G., Gemmati, D., & Tisato, V. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.871583 · Cited by 34 · see citing works

Liver osteopontin is required to prevent the progression of age‐related nonalcoholic fatty liver disease

Gómez‐Santos, B., de Urturi, D. S., Núñez-García, M., González‐Romero, F., Buqué, X., Aurrekoetxea, I., de Juan, V. G., Gonzalez-Rellan, M. J., García‐Monzón, C., González‐Rodríguez, Á., et al. (2020) · Aging Cell · doi:10.1111/acel.13183 · Cited by 32 · see citing works

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade

Ghosh, A., Michels, J., Mezzadra, R., Venkatesh, D., Dong, L., Gomez, R., Samaan, F., Ho, Y.-J., Campesato, L. F., Mangarin, L. M. B., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148141 · Cited by 30 · see citing works

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

Nolt, G. L., Keeble, A. R., Wen, Y., Strong, A. C., Thomas, N. T., Valentino, T. R., Brightwell, C. R., Murach, K. A., Patrizia, S., Weinstabl, H., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00976-2 · Cited by 27 · see citing works

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)

Rolt, A., Nair, A., & Cox, L. S. (2019) · Biogerontology · doi:10.1007/s10522-019-09796-4 · Cited by 28 · see citing works

MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present)

Rusiecki, R., Witkowski, J., & Jaszczewska‐Adamczak, J. A. (2019) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892814666191022163540 · Cited by 27 · see citing works

A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells

Patel, R. S., Romero, R., Watson, E. V., Liang, A. C. T., Burger, M. L., Westcott, P. M. K., Mercer, K. L., Bronson, R. T., Wooten, E. C., Bhutkar, A. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27731-5 · Cited by 25 · see citing works

Senescent neutrophils: a hidden role in cancer progression

Rys, R. N., & Calcinotto, A. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.09.001 · Cited by 25 · see citing works

Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease

Pedroza-Díaz, J., Arroyave-Ospina, J. C., Salas, S. S., & Moshage, H. J. (2022) · Antioxidants · doi:10.3390/antiox11050975 · Cited by 23 · see citing works

p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance

Souza, L. C. D. M. E., Faletti, A., Veríssimo, C. P., Stelling, M. P., & Borges, H. L. (2022) · Membranes · doi:10.3390/membranes12020202 · Cited by 20 · see citing works

Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer

Weigel, C., Maczis, M. A., Palladino, E. N. D., Green, C. D., Maceyka, M. W., Guo, C., Wang, X., Dozmorov, M. G., Milstien, S., & Spiegel, S. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1638 · Cited by 20 · see citing works

Rationale for Considering Oral Idasanutlin as a Therapeutic Option for COVID-19 Patients

Zauli, G., Tisato, V., & Secchiero, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01156 · Cited by 18 · see citing works

Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury

Budeus, B., Kroepel, C., Stasch, L. M., & Klein, D. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04106-3 · Cited by 23 · see citing works

Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents

Koppula, S., Akther, M., Haque, M. E., & Kopalli, S. R. (2021) · Nutrients · doi:10.3390/nu13114058 · Cited by 18 · see citing works

The ageing immune system as a potential target of senolytics

Du, P. Y., Gandhi, A., Bawa, M., & Gromala, J. (2023) · Oxford Open Immunology · doi:10.1093/oxfimm/iqad004 · Cited by 18 · see citing works

p53‐mediated regulation of mitochondrial dynamics plays a pivotal role in the senescence of various normal cells as well as cancer cells

Kim, Y. Y., Um, J., Shin, D. J., Jeong, D. J., Hong, Y. B., & Yun, J. (2021) · The FASEB Journal · doi:10.1096/fj.202002007r · Cited by 17 · see citing works

Recent Advances in the Aging Microenvironment of Breast Cancer

Jiang, X., Shen, H., Xi, S., Fang, J., Lu, Y., Lu, Y., Zheng, J., & Fu, P. (2022) · Cancers · doi:10.3390/cancers14204990 · Cited by 16 · see citing works

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Kuehnemann, C., Hu, K., Butera, K., Patel, S. K., Bons, J., Schilling, B., Aguayo‐Mazzucato, C., & Wiley, C. D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.935106 · Cited by 15 · see citing works

p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer

Tonnessen-Murray, C. A., Ungerleider, N., Rao, S. G., Wasylishen, A. R., Frey, W. D., & Jackson, J. G. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.05.003 · Cited by 15 · see citing works

Senescence-related genes as prognostic indicators in breast cancer survival

Ungvari, Z. I., Ungvari, A., Fekete, M., Kiss, C., & Győrffy, B. (2024) · GeroScience · doi:10.1007/s11357-024-01384-w · Cited by 14 · see citing works

New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases

Wu, J., Liu, X., Liu, Y., Su, W., & Zhuo, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12060563 · Cited by 13 · see citing works

MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1

Xiang, H., Qian, Y., Zeng, J., Xu, Z.-Y., Zhang, H.-Z., Huang, J., Song, A., Xiong, J., & Zhang, C. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01294-9 · Cited by 12 · see citing works

Anti-fibrotic effects of p53 activation induced by RNA polymerase I inhibitor in primary cardiac fibroblasts

Pang, S., Chen, Y., Dai, C., Liu, T., Zhang, W., Wang, J., Cui, X., Guo, X., & Jiang, F. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174303 · Cited by 12 · see citing works

Therapeutic potential of the MDM2 inhibitor Nutlin-3 in counteracting SARS-CoV-2 infection of the eye through p53 activation

Zauli, G., Alhilali, S. M., Al-Swailem, S. A., Secchiero, P., & Voltan, R. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.902713 · Cited by 12 · see citing works

Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies

Ernst, P., & Heidel, F. H. (2021) · Cancers · doi:10.3390/cancers13040612 · Cited by 9 · see citing works

Divergent regulation of long non-coding RNAs H19 and PURPL affects cell senescence in human dermal fibroblasts

Frediani, E., Anceschi, C., Ruzzolini, J., Ristori, S., Nerini, A., Laurenzana, A., Chillà, A., Germiniani, C. E. Z., Fibbi, G., Rosso, M. D., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01399-3 · Cited by 10 · see citing works

Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines

Ullah, A., Singla, R. K., Cao, D., Chen, B., & Shen, B. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101606 · Cited by 9 · see citing works

Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence

Burnaevskiy, N., Oshima, J., & Mendenhall, A. (2022) · GeroScience · doi:10.1007/s11357-022-00709-x · Cited by 10 · see citing works

Alangium longiflorum Merr. Leaf Extract Induces Apoptosis in A549 Lung Cancer Cells with Minimal NFκB Transcriptional Activation

Marquez, C. M., Garcia, J. G., Antonio, J. G., Jacinto, S. D., & Velarde, M. C. (2020) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2020.21.8.2453 · Cited by 7 · see citing works

Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19

Bortot, B., Romani, A., Ricci, G., & Biffi, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.877422 · Cited by 6 · see citing works

Design principles of gene circuits for longevity

Godoy, P., & Hao, N. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2025.02.006 · Cited by 5 · see citing works

Role of MicroRNAs in acceleration of vascular endothelial senescence

Toyama, K., Spin, J. M., Deng, A. C., Abe, Y., Tsao, P. S., & Mogi, M. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101281 · Cited by 5 · see citing works

Upregulated microRNA‐450b‐5p represses the development of acute liver failure via modulation of liver function, inflammatory response, and hepatocyte apoptosis

Fang, J., Kuang, J., Hu, S., Yang, X., Wan, W., Li, J., & Fan, X. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.767 · Cited by 5 · see citing works

Prediction of protein – peptide binding residues using classification algorithms

Shafiee, S., Fathi, A., & Abdali-Mohammadi, F. (2020) · IEEE International Conference on Bioinformatics and Bioengineering (BIBE) · doi:10.1109/bibe50027.2020.00013 · Cited by 5 · see citing works

Sénothérapies

Véret, D., & Brondello, J. (2020) · médecine/sciences · doi:10.1051/medsci/2020220 · Cited by 5 · see citing works

Mosaic Regulation of Stress Pathways Underlies Senescent Cell HeterogeneityPreprint

Avelar, R. A., Duffield, T., Lagger, C., Krstevska, N., Breuer, M., & de Magalhães, J. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.03.616489 · Cited by 5 · see citing works

Temporal regulation of gene expression and pathways in chemotherapy-induced senescence in HeLa cervical cancer cell line

Sucularlı, C., Demir, Y. D. Ş., Özdemir, A., & Ark, M. (2024) · Biosystems · doi:10.1016/j.biosystems.2024.105140 · Cited by 4 · see citing works

Cellular Senescence in Diffuse Gliomas: From Physiopathology to Possible Treatments

Ordóñez-Rubiano, E. G., Cómbita, A. L., Baldoncini, M., Payán‐Gómez, C., Gómez-Amarillo, D. F., Hakim, F., Camargo, J., Zorro-Sepúlveda, V., Luzzi, S., Zorro, Ó., et al. (2024) · World Neurosurgery · doi:10.1016/j.wneu.2024.08.060 · Cited by 5 · see citing works

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

Bar, S., Hilsabeck, T. A. U., Pattavina, B., López-Domínguez, J. A., Basisty, N., Bons, J., Watson, M., Schilling, B., Campisi, J., Kapahi, P., et al. (2025) · Aging · doi:10.18632/aging.206224 · Cited by 3 · see citing works

Artificial Intelligence for Predicting Lung Immune Responses to Viral Infections: From Mechanistic Insights to Clinical Applications

Tana, C., Soloperto, M., Giuliano, G., Erroi, G., Maggio, A. D., Tortorella, C., & Moffa, L. (2025) · Viruses · doi:10.3390/v17111482 · Cited by 3 · see citing works

Pharmacological CDK4/6 inhibition unravels a p53-induced secretory phenotype in senescent cellsPreprint

Wang, B., Brandenburg, S. M., Hernandez‐Segura, A., van Vliet, T., Jongbloed, E. M., Wilting, S. M., Ohtani, N., Jager, A., & Demaria, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.05.135715 · Cited by 4 · see citing works

Skeletal Aging and Osteoporosis: Cellular Senescence and BeyondPreprint

Chandra, A., & Rajawat, J. (2021) · Preprints.org · doi:10.20944/preprints202102.0127.v1 · Cited by 2 · see citing works

Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway

Kim, S. Y., Lee, B., Lee, J., Kwak, M. S., Rhee, W. J., Park, I. H., & Shin, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02708-1 · Cited by 2 · see citing works

Cellular senescence during aging and chronic liver diseases

Jurk, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00005-5 · Cited by 2 · see citing works

Abstract 4864: Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Schaum, N., Wiley, C. D., Almirah, F., Lopez-Dominguez, J. A., Scott, G. K., Benz, C. C., Campisi, J., & Davalos, A. R. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4864

Abstract 1271: MDM2 small molecule inhibitors synergize with chemotherapeutics to attenuate senescence-driven inflammatory secretion

Schaum, N., Almirah, F., Scott, G. K., Benz, C. C., Campisi, J., & Davalos, A. R. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-1271

Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells

Huang, B., Deo, D. D., Xia, M., & Vassilev, L. T. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0144 · Cited by 72 · see citing works

Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin

Efeyan, A., Ortega-Molina, A., Velasco-Miguel, S., Herranz, D., Vassilev, L. T., & Serrano, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0200 · Cited by 140 · see citing works

p53/MDM2 signaling pathway in aging, senescence and tumorigenesis

Huang, Y., Che, X., Wang, P., & Qu, X. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.05.001 · Cited by 92 · see citing works