Lam, Byron L.

Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

Schwartz, S. D., Regillo, C. D., Lam, B. L., Eliott, D., Rosenfeld, P. J., Gregori, N. Z., Hubschman, J.-P., Davis, J. L., Heilwell, G., Spirn, M., et al. (2015) · The Lancet

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 1,327

Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR

Cehajic-Kapetanovic, J., Xue, K., Martinez-Fernandez de la Camara, C., Nanda, A., Davies, A., Wood, L. J., Salvetti, A. P., Fischer, M. D., Aylward, J. W., Barnard, A. R., et al. (2020) · Nature Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 368

Gene Editing for CEP290 -Associated Retinal Degeneration

Pierce, E. A., Aleman, T. S., Jayasundera, K. T., Ashimatey, B. S., Kim, K., Rashid, A., Jaskolka, M. C., Myers, R. L., Lam, B. L., Bailey, S. T., et al. (2024) · New England Journal of Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 237

Gene Therapy for Leber Hereditary Optic Neuropathy

Feuer, W. J., Schiffman, J. C., Davis, J. L., Porciatti, V., Gonzalez, P., Koilkonda, R. D., Yuan, H., Lalwani, A., Lam, B. L., & Guy, J. (2016) · Ophthalmology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 230

Gene Therapy for Leber Hereditary Optic Neuropathy

Guy, J., Feuer, W. J., Davis, J. L., Porciatti, V., Gonzalez, P. J., Koilkonda, R. D., Yuan, H., Hauswirth, W. W., & Lam, B. L. (2017) · Ophthalmology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 204

Choroideremia gene therapy phase 2 clinical trial: 24-month results

Lam, B. L., Davis, J. L., Gregori, N. Z., MacLaren, R. E., Girach, A., Verriotto, J. D., Rodriguez, B., Rosa, P. R., Zhang, X., & Feuer, W. J. (2019) · American Journal of Ophthalmology

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 161

Trial End Points and Natural History in Patients With G11778A Leber Hereditary Optic Neuropathy: Preparation for Gene Therapy Clinical Trial

Lam, B. L., Feuer, W. J., Schiffman, J. C., Porciatti, V., Vandenbroucke, R., Rosa, P. R., Gregori, G., & Guy, J. (2014) · JAMA Ophthalmology

Glaucoma and retinal disordersRetinal Development and Disorders

Cited by 96

Surgical technique for subretinal gene therapy in humans with inherited retinal degeneration

Davis, J. L., Gregori, N. Z., MacLaren, R. E., & Lam, B. L. (2019) · Retina

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 72

Pain in Anterior Ischemic Optic Neuropathy

Swartz, N. G., Beck, R. W., Savino, P. J., Sergott, R. C., Bosley, T. M., Lam, B. L., Drucker, M., & Katz, B. (1995) · Journal of Neuro-Ophthalmology

Multiple Sclerosis Research StudiesGlaucoma and retinal disorders

Cited by 70

Subretinal timrepigene emparvovec in adult men with choroideremia: a randomized phase 3 trial

MacLaren, R. E., Fischer, M. D., Gow, J. A., Lam, B. L., Sankila, E.-M. K., Girach, A., Panda, S., Yoon, D., Zhao, G., & Pennesi, M. E. (2023) · Nature Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 58

Stargardt macular dystrophy and evolving therapies

Hussain, R. M., Ciulla, T. A., Berrocal, A. M., Gregori, N. Z., Flynn, H. W., & Lam, B. L. (2018) · Expert Opinion on Biological Therapy

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 56

Intraoperative use of microscope-integrated optical coherence tomography for subretinal gene therapy delivery

Gregori, N. Z., Lam, B. L., & Davis, J. L. (2019) · Retina

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 54

Assessment of visual function with cotoretigene toliparvovec in X-linked retinitis pigmentosa in the randomized XIRIUS phase 2/3 study

Lam, B. L., Pennesi, M. E., Kay, C. N., Panda, S., Gow, J. A., Zhao, G., MacLaren, R. E., MacLaren, R., Aleman, T., Birch, D., et al. (2024) · Ophthalmology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 51

Leber hereditary optic neuropathy gene therapy: adverse events and visual acuity results of all patient groups

Lam, B. L., Feuer, W. J., Davis, J. L., Porciatti, V., Yu, H., Levy, R. B., Vanner, E., & Guy, J. (2022) · American Journal of Ophthalmology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 43

An open-label phase II study assessing the safety of bilateral, sequential administration of retinal gene therapy in participants with choroideremia: the GEMINI study

MacLaren, R. E., Audo, I., Fischer, M. D., Huckfeldt, R. M., Lam, B. L., Pennesi, M. E., Sisk, R., Gow, J. A., Li, J., Zhu, K., et al. (2024) · Human Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 15