Intraoperative use of microscope-integrated optical coherence tomography for subretinal gene therapy delivery
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Gregori, Ninel Z. MD; Lam, Byron L. MD; Davis, Janet L. MDEditor(s): Williams, George A. Author Information
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Despite intraoperative OCT, practical limitations include restricted OCT fields, shadowing of the operative site by intravitreal instruments, and inability for surgeons to operate and observe the iOCT image in real time.
“there are still practical limitations in iOCT systems including restricted OCT fields, shadowing of the operative site by intravitreal instruments and the inability for surgeons to operate and observe the iOCT image in real time.”
From Subretinal therapy: technological solutions to surgical and immunological challenges (2022) · cites this paper as [16]
Cites
MacLaren, R. E., Groppe, M., Barnard, A. R., Cottriall, C. L., Tolmachova, T., Seymour, L., Clark, K. R., During, M. J., Cremers, F. P. M., Black, G. C. M., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62117-0 · Cited by 796 · see citing works
Ehlers, J. P., Dupps, W. J., Kaiser, P. K., Goshe, J. M., Singh, R. P., Petkovsek, D. S., & Srivastava, S. K. (2014) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2014.07.034 · Cited by 226 · see citing works
Weleber, R. G., Pennesi, M. E., Wilson, D. J., Kaushal, S., Erker, L. R., Jensen, L., McBride, M. T., Flotte, T. R., Humphries, M., Calcedo, R., et al. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.03.003 · Cited by 218 · see citing works
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Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier
MacLaren, R. E., Bennett, J., & Schwartz, S. D. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.06.041 · Cited by 79 · see citing works
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Guo, S., & Kang, J. U. (2022) · Optics Express · doi:10.1364/oe.462980 · Cited by 6 · see citing works
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- Authors
- Gregori, N. Z., Lam, B. L., & Davis, J. L.
- Affiliations
- University of Miami (US)
- Corresponding author
- Gregori, Ninel Z.
- Lam, Byron L.
- Davis, Janet L.
- Venue
- Retina
- Published
- 2019-10
- Volume
- 39
- Issue
- 1
- Pages
- S9-S12
- ISSN
- 0275-004X (ISSN-L)
- OpenAlex
- W2605752008
- Cited by
- 54
- References
- 5
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Retina (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Keywords
- optical coherence tomography, subretinal gene therapy, gene delivery, intraoperative imaging, retinal gene therapy
- MeSH terms
- Female, Genetic Vectors, Humans, Male, Microscopy, Retinal Degeneration, Genetic Therapy, Monitoring, Intraoperative, Tomography, Optical Coherence
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