Armstrong, Scott A.

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell

FOXO transcription factor regulationHematopoietic Stem Cell Transplantation

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

Krivtsov, A. V., Twomey, D., Feng, Z., Stubbs, M. C., Wang, Y., Faber, J., Levine, J. E., Wang, J., Hahn, W. C., Gilliland, D. G., et al. (2006) · Nature

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

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The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

Stein, E. M., Garcia-Manero, G., Rizzieri, D. A., Tibes, R., Berdeja, J. G., Savona, M. R., Jongen-Lavrenic, M., Altman, J. K., Thomson, B., Blakemore, S. J., et al. (2018) · Blood

Acute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research

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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science

Cancer-related Molecular PathwaysAcute Myeloid Leukemia Research

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Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche

Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

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Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Rampal, R., Ahn, J., Abdel-Wahab, O., Nahas, M., Wang, K., Lipson, D., Otto, G. A., Yelensky, R., Hricik, T., McKenney, A. S., et al. (2014) · Proceedings of the National Academy of Sciences

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

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DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., et al. (2016) · Nature Medicine

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

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Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

Krivtsov, A. V., Figueroa, M. E., Sinha, A. U., Stubbs, M. C., Feng, Z., Valk, P. J. M., Delwel, R., Döhner, K., Bullinger, L., Kung, A. L., et al. (2013) · Leukemia

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Placke, T., Faber, K., Nonami, A., Putwain, S. L., Salih, H. R., Heidel, F. H., Krämer, A., Root, D. E., Barbie, D. A., Krivtsov, A. V., et al. (2014) · Blood

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

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HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

Sun, Y., Zhou, B., Mao, F., Xu, J., Miao, H., Zou, Z., Phuc Khoa, L. T., Jang, Y., Cai, S., Witkin, M., et al. (2018) · Cancer Cell

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

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Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

Trowbridge, J. J., Sinha, A. U., Zhu, N., Li, M., Armstrong, S. A., & Orkin, S. H. (2012) · Genes & Development

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

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IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation

Park, S.-M., Cho, H., Thornton, A. M., Barlowe, T. S., Chou, T., Chhangawala, S., Fairchild, L., Taggart, J., Chow, A., Schurer, A., et al. (2019) · Cell Stem Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Tsai, J. M., Aguirre, J. D., Li, Y.-D., Brown, J., Focht, V., Kater, L., Kempf, G., Sandoval, B., Schmitt, S., Rutter, J. C., et al. (2023) · Molecular Cell

Estrogen and related hormone effectsUbiquitin and proteasome pathways

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High-resolution characterization of gene function using single-cell CRISPR tiling screen

Yang, L., Chan, A. K. N., Miyashita, K., Delaney, C. D., Wang, X., Li, H., Pokharel, S. P., Li, S., Li, M., Xu, X., et al. (2021) · Nature Communications

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

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Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues

Ojeda, S., Wang, M., Baek, K., Bourgeois, W., Sommerschield, A., Yue, H., Metivier, R. J., Karagiannis, P., Levitz, T. S., Xiong, Y., et al. (2026) · Science

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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