DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
Open accessAbstract
Although the majority of patients with acute myeloid leukemia (AML) initially respond to chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML persistence following chemotherapy has not been determined. Recurrent somatic mutations in DNA methyltransferase 3A (DNMT3A), most frequently at arginine 882 (DNMT3A R882), have been observed in AML and in individuals with clonal hematopoiesis in the absence of leukemic transformation. Patients with DNMT3A R882 AML have an inferior outcome when treated with standard-dose daunorubicin-based induction chemotherapy, suggesting that DNMT3A R882 cells persist and drive relapse. We found that Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 gene (Flt3 ITD) and the nucleophosmin gene (Npm1 c) to induce AML in vivo, and promoted resistance to anthracycline chemotherapy. In patients with AML, the presence of DNMT3A R882 mutations predicts minimal residual disease, underscoring their role in AML chemoresistance. DNMT3A R882 cells showed impaired nucleosome eviction and chromatin remodeling in response to anthracycline treatment, which resulted from attenuated recruitment of histone chaperone SPT-16 following anthracycline exposure. This defect led to an inability to sense and repair DNA torsional stress, which resulted in increased mutagenesis. Our findings identify a crucial role for DNMT3A R882 mutations in driving AML chemoresistance and highlight the importance of chromatin remodeling in response to cytotoxic chemotherapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mouse models carrying loss-of-function mutations in either TET2 or DNMT3A show an HSC competitive advantage in vivo as well as a propensity for leukemia when cooperating mutations are present.
“Mouse models carrying loss-of-function mutations in either of these genes clearly show an HSC competitive advantage in vivo as well as a propensity for leukemia when cooperating mutations are present 50–53.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Self-citationSTAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078 · see citing works
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
Genomic classification and prognosis in acute myeloid leukemia
Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., Potter, N. E., Heuser, M., Thol, F., Bolli, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516192 · Cited by 4,350 · see citing works
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617 · see citing works
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
Akalin, A., Kormáksson, M., Li, S., Garrett-Bakelman, F. E., Figueroa, M. E., Melnick, A. M., & Mason, C. E. (2012) · Genome biology · doi:10.1186/gb-2012-13-10-r87 · Cited by 2,205 · see citing works
Self-citationMemorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)
Cheng, D. T., Mitchell, T. N., Zehir, A., Shah, R. H., Benayed, R., Syed, A., Chandramohan, R., Liu, Z. Y., Won, H. H., Scott, S. N., et al. (2015) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.12.006 · Cited by 2,119 · see citing works
Self-citation<i>DNMT3A</i> Mutations in Acute Myeloid Leukemia
Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983 · see citing works
Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
Patel, J. P., Gönen, M., Figueroa, M. E., Fernandez, H. F., Sun, Z., Racevskis, J., Vlierberghe, P. V., Dolgalev, I., Thomas, S., Aminova, O., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112304 · Cited by 1,936 · see citing works
Self-citationThe origin and evolution of mutations in acute myeloid leukemia
Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575 · see citing works
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527 · see citing works
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443 · see citing works
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339 · see citing works
Self-citationDnmt3a is essential for hematopoietic stem cell differentiation
Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122 · see citing works
The comet assay: topical issues
Collins, A. R., Oscoz, A. A., Brunborg, G., Gaivão, I., Giovannelli, L., Kruszewski, M. K., Smith, C. C., & Štětina, R. (2008) · Mutagenesis · doi:10.1093/mutage/gem051 · Cited by 991 · see citing works
Quivoron, C., Couronné, L., Della Valle, V., Lopez, C. K., Plo, I., Wagner-Ballon, O., Do Cruzeiro, M., Delhommeau, F., Arnulf, B., Stern, M.-H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.003 · Cited by 924 · see citing works
Leiserson, M. D. M., Vandin, F., Wu, H.-T., Dobson, J. R., Eldridge, J. V., Thomas, J. L., Papoutsaki, A., Kim, Y., Niu, B., McLellan, M. D., et al. (2014) · Nature Genetics · doi:10.1038/ng.3168 · Cited by 908 · see citing works
FACT Facilitates Transcription-Dependent Nucleosome Alteration
Belotserkovskaya, R., Oh, S., Bondarenko, V. A., Orphanides, G., Studitsky, V. M., & Reinberg, D. (2003) · Science · doi:10.1126/science.1085703 · Cited by 869 · see citing works
Assessment of Minimal Residual Disease in Standard-Risk AML
Ivey, A., Hills, R. K., Simpson, M. A., Jovanovic, J. V., Gilkes, A., Grech, A., Patel, Y., Bhudia, N., Farah, H., Mason, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1507471 · Cited by 848 · see citing works
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830 · see citing works
Self-citationYan, X., Xu, J., Gu, Z., Pan, C., Lü, G., Shen, Y., Shi, J., Zhu, Y., Tang, L., Zhang, X., et al. (2011) · Nature Genetics · doi:10.1038/ng.788 · Cited by 806 · see citing works
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004315 · Cited by 721 · see citing works
Doxorubicin, DNA torsion, and chromatin dynamics
Yang, F., Teves, S. S., Kemp, C. J., & Henikoff, S. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.12.002 · Cited by 713 · see citing works
Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts
Socolovsky, M., Nam, H.-S., Fleming, M. D., Haase, V. H., Brugnara, C., & Lodish, H. F. (2001) · Blood · doi:10.1182/blood.v98.12.3261 · Cited by 674 · see citing works
Li, Z., Cai, X., Cai, C.-L., Wang, J., Zhang, W., Petersen, B. E., Yang, F.-C., & Xu, M. (2011) · Blood · doi:10.1182/blood-2010-12-325241 · Cited by 671 · see citing works
Chen, K., Liu, J., Heck, S., Chasis, J. A., An, X., & Mohandas, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909296106 · Cited by 516 · see citing works
DNMT3A in haematological malignancies
Yang, L., Rau, R. E., & Goodell, M. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3895 · Cited by 509 · see citing works
Russler-Germain, D. A., Spencer, D. H., Young, M. A., Lamprecht, T. L., Miller, C. A., Fulton, R., Meyer, M. R., Erdmann-Gilmore, P., Townsend, R. R., Wilson, R. K., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.010 · Cited by 452 · see citing works
Pang, B., Qiao, X., Janssen, L., Velds, A., Groothuis, T. A., Kerkhoven, R. M., Nieuwland, M., Ovaa, H., Rottenberg, S., van Tellingen, O., et al. (2013) · Nature Communications · doi:10.1038/ncomms2921 · Cited by 417 · see citing works
Chaperoning Histones during DNA Replication and Repair
Ransom, M., Dennehey, B. K., & Tyler, J. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.004 · Cited by 345 · see citing works
Akalin, A., Garrett-Bakelman, F. E., Kormaksson, M., Busuttil, J., Zhang, L., Khrebtukova, I., Milne, T. A., Huang, Y., Biswas, D., Hess, J. L., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002781 · Cited by 296 · see citing works
Self-citationMutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia
Ribeiro, A. F. T., Pratcorona, M., Erpelinck-Verschueren, C. A. J., Ročková, V., Sanders, M. A., Abbas, S., Figueroa, M. E., Zeilemaker, A., Melnick, A. M., Löwenberg, B., et al. (2012) · Blood · doi:10.1182/blood-2011-07-367961 · Cited by 261 · see citing works
Self-citationChen, X., Xie, H., Wood, B. L., Walter, R. B., Pagel, J. M., Becker, P. S., Sandhu, V. K., Abkowitz, J. L., Appelbaum, F. R., & Estey, E. H. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3518 · Cited by 257 · see citing works
Stracker, T. H., Usui, T., & Petrini, J. H. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.012 · Cited by 245 · see citing works
Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.009 · Cited by 236 · see citing works
Self-citationWalter, R. B., Gyurkocza, B., Storer, B. E., Godwin, C. D., Pagel, J. M., Buckley, S. A., Sorror, M. L., Wood, B. L., Storb, R. F., Appelbaum, F. R., et al. (2014) · Leukemia · doi:10.1038/leu.2014.173 · Cited by 217 · see citing works
Nguyen, S. P., Meletis, K., Fu, D., Jhaveri, S., & Jaenisch, R. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21176 · Cited by 195 · see citing works
p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.
Havre, P. A., Yuan, J., Hedrick, L., Cho, K. R., & Glazer, P. M. (1995) · PubMed · Cited by 189 · see citing works
p Value Adjustments for Multiple Tests in Multivariate Binomial Models
Westfall, P. H., & Young, S. S. (1989) · Journal of the American Statistical Association · doi:10.1080/01621459.1989.10478837 · Cited by 187 · see citing works
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Kim, S. J., Zhao, H., Hardikar, S., Singh, A. K., Goodell, M. A., & Chen, T. (2013) · Blood · doi:10.1182/blood-2013-02-483487 · Cited by 180 · see citing works
Gaidzik, V. I., Schlenk, R. F., Paschka, P., Stölzle, A., Späth, D., Kuendgen, A., von Lilienfeld‐Toal, M., Brugger, W., Derigs, H. G., Kremers, S., et al. (2013) · Blood · doi:10.1182/blood-2012-10-461624 · Cited by 176 · see citing works
AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes
Deshpande, A., Deshpande, A., Sinha, A., Chen, L., Chang, J., Cihan, A., Fazio, M., Chen, C., Zhu, N., Koche, R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.009 · Cited by 172 · see citing works
Self-citationAn optimized algorithm for detecting and annotating regional differential methylation
Li, S., Garrett-Bakelman, F. E., Akalin, A., Zumbo, P., Levine, R. L., To, B. L., Lewis, I. D., Brown, A. L., D’Andrea, R. J., Melnick, A. M., et al. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-s5-s10 · Cited by 146 · see citing works
Self-citationEnhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage
Dinant, C., Ampatziadis-Michailidis, G., Lans, H., Tresini, M., Lagarou, A., Grosbart, M., Theil, A. F., van Cappellen, W. A., Kimurâ, H., Bártek, J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.007 · Cited by 145 · see citing works
Holz-Schietinger, C., Matje, D. M., & Reich, N. O. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366625 · Cited by 140 · see citing works
Flow cytometry analysis of murine hematopoietic stem cells
Mayle, A., Luo, M., Jeong, M., & Goodell, M. A. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22093 · Cited by 118 · see citing works
Minimal residual disease in acute myeloid leukemia: coming of age
Paietta, E. M. (2012) · Hematology · doi:10.1182/asheducation.v2012.1.35.3797926 · Cited by 109 · see citing works
Self-citationGarrett-Bakelman, F. E., Sheridan, C. K., Kacmarczyk, T. J., Ishii, J. K., Betel, D., Alonso, A., Mason, C. E., Figueroa, M. E., & Melnick, A. M. (2015) · Journal of Visualized Experiments · doi:10.3791/52246 · Cited by 103 · see citing works
Self-citationIdentifying novel proteins recognizing histone modifications using peptide pull-down assay
Wysocka, J. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.028 · Cited by 88 · see citing works
Assessment of Minimal Residual Disease in Standard-Risk AML
Hills, R. K., Ivey, A., & Grimwade, D. J. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1603847 · Cited by 82 · see citing works
Othus, M. K. D., Wood, B. L., Stirewalt, D. L., et al. (2016) · Leukemia · doi:10.1038/leu.2016.120 · Cited by 80 · see citing works
p Value Adjustments for Multiple Tests in Multivariate Binomial Models
Westfall, P. H., & Young, S. S. (1989) · Journal of the American Statistical Association · doi:10.2307/2289666 · Cited by 74 · see citing works
Sehgal, A. R., Gimotty, P. A., Zhao, J., Hsu, J., Daber, R. D., Morrissette, J. D., Luger, S. M., Loren, A. W., & Carroll, M. P. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0327 · Cited by 57 · see citing works
Ostronoff, F., Othus, M. K. D., Ho, P. A., et al. (2012) · Leukemia · doi:10.1038/leu.2012.168 · Cited by 52 · see citing works
Tie, R., Zhang, T., Fu, H., Wang, L., Wang, Y., He, Y., Wang, B., Zhu, N., Fu, S., Lai, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093353 · Cited by 47 · see citing works
Should minimal residual disease guide therapy in AML?
Paietta, E. M. (2015) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2015.10.006 · Cited by 17 · see citing works
Self-citationGanzel, C., Sun, Z., Gönen, M., et al. (2014) · Blood · doi:10.1182/blood.v124.21.1016.1016 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340 · see citing works
Clonal hematopoiesis in human aging and disease
Jaiswal, S., & Ebert, B. L. (2019) · Science · doi:10.1126/science.aan4673 · Cited by 1,156 · see citing works
Coombs, C. C., Zehir, A., Devlin, S. M., Kishtagari, A., Syed, A., Jonsson, P., Hyman, D. M., Solit, D. B., Robson, M. E., Baselga, J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.010 · Cited by 866 · see citing works
Self-citationClonal Hematopoiesis and Evolution to Hematopoietic Malignancies
Bowman, R. L., Busque, L., & Levine, R. L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.011 · Cited by 448 · see citing works
Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion
Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1410-1 · Cited by 391 · see citing works
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
Jeong, M., Park, H. J., Celik, H., Ostrander, E. L., Reyes, J. M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.025 · Cited by 243 · see citing works
Self-citationHematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis
Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jäger, M., Yoshida, K., Seemann, R., Noerenberg, D., Waldhueter, N., Fleischer-Notter, H., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0047-7 · Cited by 194 · see citing works
Glass, J. L., Hassane, D., Wouters, B. J., Kunimoto, H., Avellino, R., Garrett-Bakelman, F. E., Guryanova, O. A., Bowman, R., Redlich, S., Intlekofer, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1032 · Cited by 142 · see citing works
Self-citationClonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones
Challen, G., & Goodell, M. A. (2020) · Blood · doi:10.1182/blood.2020006510 · Cited by 131 · see citing works
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129 · see citing works
Cole, C. B., Russler-Germain, D. A., Ketkar, S., Verdoni, A. M., Smith, A. M., Bangert, C. V., Helton, N. M., Guo, M., Klco, J. M., O’Laughlin, S., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93041 · Cited by 84 · see citing works
Rodenhizer, D., Dean, T., D'Arcangelo, E., & McGuigan, A. P. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701174 · Cited by 80 · see citing works
Tovy, A., Reyes, J. M., Gundry, M. C., Brunetti, L., Lee-Six, H., Petljak, M., Park, H. J., Guzman, A. G., Rosas, C., Jeffries, A. R., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.06.018 · Cited by 30 · see citing works
- Authors
- Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., Rivera, S. A., Chramiec, A. G., Pronier, E., Bastian, L., Keller, M. D., Tovbin, D., Loizou, E., Weinstein, A. R., Gonzalez, A. R., Lieu, Y. K., Rowe, J. M., Pastore, F., McKenney, A. S., Krivtsov, A. V., Sperr, W. R., Cross, J. R., Mason, C. E., Tallman, M. S., Arcila, M. E., Abdel-Wahab, O., Armstrong, S. A., Kubicek, S., Staber, P. B., Gönen, M., Paietta, E. M., Melnick, A. M., Nimer, S. D., Mukherjee, S., & Levine, R. L.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- University of Miami (US)
- Weill Cornell Medicine (US)
- Shaare Zedek Medical Center (IL)
- Medical University of Vienna (AT)
- Columbia University (US)
- Comprehensive Cancer Center Vienna (AT)
- Cornell University (US)
- Austrian Academy of Sciences (AT)
- Montefiore Medical Center (US)
- Corresponding author
- Mukherjee, Siddhartha
- Levine, Ross L
- ORCID
- Guryanova, Olga A
- Spitzer, Barbara
- Koche, Richard P
- Garrett-Bakelman, Francine E
- Ganzel, Chezi
- Durham, Benjamin H
- Mohanty, Abhinita
- Hoermann, Gregor
- Chramiec, Alan G
- Rowe, Jacob M
- Pastore, Friederike
- McKenney, Anna Sophia
- Krivtsov, Andrei V
- Sperr, Wolfgang R
- Cross, Justin R
- Mason, Christopher E
- Tallman, Martin S
- Arcila, Maria E
- Abdel-Wahab, Omar
- Armstrong, Scott A
- Kubicek, Stefan
- Staber, Philipp B
- Gönen, Mithat
- Paietta, Elisabeth M
- Melnick, Ari M
- Nimer, Stephen D
- Mukherjee, Siddhartha
- Levine, Ross L
- Venue
- Nature Medicine
- Published
- 2016-11-14
- Volume
- 22
- Issue
- 12
- Pages
- 1488-1495
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC5359771
- OpenAlex
- W2551286426
- Cited by
- 256
- References
- 62
- Citations by year
- 2026: 9 · 2025: 25 · 2024: 19 · 2023: 23 · 2022: 26 · 2021: 33 · 2020: 40 · 2019: 32 · 2018: 20 · 2017: 28 · 2016: 1
- FWCI
- 25.55
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- European Hematology Association (TRTH89)
- National Cancer Institute (U10CA180820, U10CA180791, UG1CA189859, R00CA178191, K08CA169055, K99CA178191, U10CA180794, R01CA169784, U10CA180827, P30CA008748, U24CA196172, K12CA184746)
- National Institute of General Medical Sciences (T32GM007739)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- acute myeloid leukemia, anthracycline resistance, nucleosome remodeling, chromatin remodeling, DNA repair, DNA torsional stress, histone chaperone, hematopoietic stem cell expansion, FLT3-ITD, NPM1, minimal residual disease, relapse
- MeSH terms
- DNA Methyltransferase 3A, Nucleophosmin, Animals, Antineoplastic Agents, Cell Survival, Daunorubicin, DNA (Cytosine-5-)-Methyltransferases, Hematopoietic Stem Cells, Humans, Mutation, Nuclear Proteins, Nucleosomes, Mass Spectrometry, Immunoblotting, Leukemia, Myeloid, Acute, Anthracyclines, Drug Resistance, Neoplasm, Chromatin Assembly and Disassembly, Cell Line, Tumor, Immunoprecipitation, Cell Proliferation, Mice, fms-Like Tyrosine Kinase 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
