Roma, Guglielmo

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

Plasschaert, L. W., Žilionis, R., Choo-Wing, R., Savova, V., Knehr, J., Roma, G., Klein, A. M., & Jaffe, A. B. (2018) · Nature

Cystic Fibrosis Research AdvancesSingle-cell and spatial transcriptomics

Cited by 1,047

The genome of melon ( Cucumis melo L.)

Garcia-Mas, J., Benjak, A., Sanseverino, W., Bourgeois, M., Mir, G., González, V. M., Hénaff, E., Câmara, F., Cozzuto, L., Lowy, E., et al. (2012) · Proceedings of the National Academy of Sciences

Advances in Cucurbitaceae ResearchGenomics and Phylogenetic Studies

Cited by 744

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Cowan, C. S., Renner, M., De Gennaro, M., Gross-Scherf, B., Goldblum, D., Hou, Y., Munz, M., Rodrigues, T. M., Krol, J., Szikra, T., et al. (2020) · Cell

Retinal Development and DisordersSingle-cell and spatial transcriptomics

Cited by 654

Self-organization and symmetry breaking in intestinal organoid development

Serra, D., Mayr, U., Boni, A., Lukonin, I., Rempfler, M., Challet Meylan, L., Stadler, M. B., Strnad, P., Papasaikas, P., Vischi, D., et al. (2019) · Nature

Hippo pathway signaling and YAP/TAZDevelopmental Biology and Gene Regulation

Cited by 561

TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine

PI3K/AKT/mTOR signaling in cancerGenetics, Aging, and Longevity in Model Organisms

Cited by 496

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

Palacino, J., Swalley, S. E., Song, C., Cheung, A. K., Shu, L., Zhang, X., Van Hoosear, M., Shin, Y., Chin, D. N., Keller, C. G., et al. (2015) · Nature Chemical Biology

Neurogenetic and Muscular Disorders ResearchRNA Research and Splicing

Cited by 432

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics

Hippo pathway signaling and YAP/TAZGenomics and Chromatin Dynamics

Cited by 414

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 359

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 216

Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues

Shavlakadze, T., Morris, M., Fang, J., Wang, S. X., Zhu, J., Zhou, W., Tse, H. W., Mondragon-Gonzalez, R., Roma, G., & Glass, D. J. (2019) · Cell Reports

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 170

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 166

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

Bidinosti, M., Botta, P., Krüttner, S., Proenca, C. C., Stoehr, N., Bernhard, M., Fruh, I., Mueller, M., Bonenfant, D., Voshol, H., et al. (2016) · Science

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 151

Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4

Luis, N. M., Morey, L., Mejetta, S., Pascual, G., Janich, P., Kuebler, B., Roma, G., Nascimento, E., Frye, M., Di Croce, L., et al. (2011) · Cell stem cell

Epigenetics and DNA MethylationHair Growth and Disorders

Cited by 142

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

Wang, Z.-Y., Keogh, A., Waldt, A., Cuttat, R., Neri, M., Zhu, S., Schuierer, S., Ruchti, A., Crochemore, C., Knehr, J., et al. (2021) · Scientific Reports

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 103

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

Potting, C., Crochemore, C., Moretti, F., Nigsch, F., Schmidt, I., Manneville, C., Carbone, W., Knehr, J., DeJesus, R., Lindeman, A., et al. (2018) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 93

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 84

Decatransin, a novel natural product inhibiting protein translocation at the Sec61/SecY translocon

Junne, T., Wong, J., Studer, C., Aust, T., Bauer, B. W., Beibel, M., Bhullar, B., Bruccoleri, R., Eichenberger, J., Estoppey, D., et al. (2015) · Journal of Cell Science

Microbial Natural Products and BiosynthesisBacterial Genetics and Biotechnology

Cited by 67

Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

Dhandapani, R., Neri, M., Bernhard, M., Brzak, I., Schweizer, T., Rudin, S., Joller, S., Berth, R., Kernen, J., Neuhaus, A., et al. (2022) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 60

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

Saponara, E., Penno, C., Orsini, V., Wang, Z.-Y., Fischer, A., Aebi, A., Matadamas-Guzman, M. L., Brun, V., Fischer, B., Brousseau, M., et al. (2023) · The American Journal of Pathology

Liver Disease Diagnosis and TreatmentWnt/β-catenin signaling in development and cancer

Cited by 22