YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
Open accessAbstract
YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, as well as in non-transformed cells. We demonstrate that TEAD transcription factors mediate YAP1 chromatin-binding genome-wide, further explaining their dominant role as primary mediators of YAP1-transcriptional activity. Moreover, we show that YAP1 largely exerts its transcriptional control via distal enhancers that are marked by H3K27 acetylation and that YAP1 is necessary for this chromatin mark at bound enhancers and the activity of the associated genes. This work establishes YAP1-mediated transcriptional regulation at distal enhancers and provides an expanded set of target genes resulting in a fundamental source to study YAP1 function in a normal and cancer setting.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ChIP-seq and deepsequencing studies in cancer and normal cells showed that several YAP-binding regions also show a consensus motif for AP-1 transcriptional factors, suggesting that YAP/TEAD and AP-1 cooperatively regulate target genes.
“ChIP-seq and deepsequencing studies in cancer and normal cells showed that several YAP-binding regions also show a consensus motif for AP-1 transcriptional factors suggesting that YAP/TEAD and AP-1 cooperatively regulate target genes representing a cross-talk between YAP and JNK signalling (74,75).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in <i>Drosophila</i> by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [74]
In Results (‘The TEAD consensus motif is enriched in YAP1 binding sites’; page unavailable), the paper reports AP-1 motifs in YAP1-binding regions and proposes that YAP1/TEAD might cooperate with AP-1 under particular conditions. It does not establish cooperative regulation, and the Results on non-transformed IMR90 cells identify FOX—not AP-1—as the enriched secondary motif. The cited passages also do not establish the citing sentence’s proposed YAP–JNK cross-talk. (LLM, conf=0.86)
Experimental — accuracy not yet measuredYAP/TEAD bind distal regulatory elements to regulate transcription of target genes.
“Third, YAP/TEAD bind distal regulatory elements to regulate transcription of target genes (73-75).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in <i>Drosophila</i> by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [74]
Published ChIP-seq datasets reveal a similar phenomenon in human cancer cell lines.
“Consistently, published ChIP-seq datasets34,38,39 reveal a similar phenomenon in human cancer cell lines (Figure S7F).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 4,408 · cited 1× · see citing works
“We calculated the conservation rate of regions using the PhastCons 46 way placental mammals [94].”
MethodHistone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works
Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
Maurano, M. T., Humbert, R., Rynes, E., Thurman, R. E., Haugen, E., Wang, H., Reynolds, A. P., Sandstrom, R., Qu, H., Brody, J., et al. (2012) · Science · doi:10.1126/science.1222794 · Cited by 3,716 · see citing works
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662 · see citing works
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1× · see citing works
“To gain further mechanistic insight into how YAP1 affects H3K27ac we performed ChIP-qPCR for p300, the major histone acetyltransferase that has been linked to enhancers [61, 62].”
MethodROCR: visualizing classifier performance in R
Sing, T., Sander, O., Beerenwinkel, N., & Lengauer, T. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti623 · Cited by 3,205 · see citing works
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works
MEME: discovering and analyzing DNA and protein sequence motifs
Bailey, T. L., Williams, N., Misleh, C., & Li, W. W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl198 · Cited by 2,671 · see citing works
An atlas of active enhancers across human cell types and tissues
The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550 · see citing works
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533 · see citing works
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works
Weber, M., Hellmann, I., Stadler, M. B., Ramos, L., Pääbo, S., Rebhan, M., & Schübeler, D. (2007) · Nature Genetics · doi:10.1038/ng1990 · Cited by 2,267 · see citing works
Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233 · see citing works
Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227 · see citing works
Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,870 · see citing works
The Hippo pathway and human cancer
Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,852 · see citing works
JASPAR: an open-access database for eukaryotic transcription factor binding profiles
Sandelin, A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh012 · Cited by 1,763 · see citing works
ChIP-seq accurately predicts tissue-specific activity of enhancers
Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639 · see citing works
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works
DNA-Binding Specificities of Human Transcription Factors
Jolma, A., Yan, J., Whitington, T., Toivonen, J., Nitta, K. R., Rastas, P. M. A., Morgunova, E. Y., Enge, M., Taipale, M., Wei, G., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.009 · Cited by 1,228 · see citing works
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205 · see citing works
The Hippo–YAP pathway in organ size control and tumorigenesis: an updated versionPreprint
Zhao, B., Li, L., Lei, Q., & Guan, K. (2010) · Genes & Development · doi:10.1101/gad.1909210 · Cited by 1,140 · see citing works
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
Hawkins, R. D., Hon, G. C., Lee, L. K., Ngo, Q., Lister, R., Pelizzola, M., Edsall, L. E., Kuan, S., Luu, Y., Klugman, S., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.018 · Cited by 806 · see citing works
Functional and Mechanistic Diversity of Distal Transcription Enhancers
Bulger, M., & Groudine, M. (2011) · Cell · doi:10.1016/j.cell.2011.01.024 · Cited by 803 · see citing works
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 780 · see citing works
Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767 · see citing works
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Shao, D. D., Xue, W., Krall, E. B., Bhutkar, A., Piccioni, F., Wang, X., Schinzel, A. C., Sood, S., Rosenbluh, J., Kim, J. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.004 · Cited by 744 · see citing works
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint
Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 738 · see citing works
Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L. (2001) · Genes & Development · doi:10.1101/gad.888601 · Cited by 719 · see citing works
The Hippo signaling pathway in stem cell biology and cancer
Mo, J., Park, H. W., & Guan, K. (2014) · EMBO Reports · doi:10.15252/embr.201438638 · Cited by 682 · see citing works
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
Lamar, J. M., Stern, P., Liu, H., Schindler, J. W., Jiang, Z.-G., & Hynes, R. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212021109 · Cited by 656 · see citing works
Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · see citing works
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630 · see citing works
WikiPathways: building research communities on biological pathways
Kelder, T., van Iersel, M., Hanspers, K., Kutmon, M., Conklin, B. R., Evelo, C. T., & Pico, A. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1074 · Cited by 521 · see citing works
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Verfaillie, A., Imrichova, H., Atak, Z. K., Dewaele, M., Rambow, F., Hulselmans, G., Christiaens, V., Svetlichnyy, D., Luciani, F., Van den Mooter, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7683 · Cited by 489 · see citing works
Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 427 · see citing works
Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419 · see citing works
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1
Xiao, J. H., Davidson, I., Matthes, H. W. D., Garnier, J., & Chambon, P. (1991) · Cell · doi:10.1016/0092-8674(91)90088-g · Cited by 417 · see citing works
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402 · see citing works
Ota, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 391 · see citing works
Characterization of a New Human Diploid Cell Strain, IMR-90
Nichols, W. W., Murphy, D. G., Cristofalo, V. J., Toji, L. H., Greene, A. E., & Dwight, S. (1977) · Science · doi:10.1126/science.841339 · Cited by 368 · see citing works
Wang, Y., Dong, Q., Zhang, Q., Li, Z., Wang, E., & Qiu, X. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01511.x · Cited by 341 · see citing works
The Hippo-YAP signaling pathway and contact inhibition of growth
Gumbiner, B. M., & Kim, N. (2014) · Journal of Cell Science · doi:10.1242/jcs.140103 · Cited by 339 · see citing works
Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer
Akhtar‐Zaidi, B., Sallari, R. C., Corradin, O., Saiakhova, A., Bartels, C. F., Balasubramanian, D., Myeroff, L. L., Lutterbaugh, J., Jarrar, A., Kalady, M. F., et al. (2012) · Science · doi:10.1126/science.1217277 · Cited by 337 · see citing works
Animal Transcription Networks as Highly Connected, Quantitative Continua
Biggin, M. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.008 · Cited by 308 · see citing works
How to map billions of short reads onto genomes
Trapnell, C., & Salzberg, S. L. (2009) · Nature Biotechnology · doi:10.1038/nbt0509-455 · Cited by 307 · see citing works
Beyer, T. A., Weiss, A., Khomchuk, Y., Huang, K., Ogunjimi, A. A., Varelas, X., & Wrana, J. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.021 · Cited by 293 · see citing works
Davidson, I., Xiao, J. H., Rosales, R., Staub, A., & Chambon, P. (1988) · Cell · doi:10.1016/0092-8674(88)90108-0 · Cited by 287 · see citing works
Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
Song, S., Ajani, J. A., Honjo, S., Maru, D. M., Chen, Q., Scott, A. W., Heallen, T. R., Xiao, L., Hofstetter, W. L., Weston, B. R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3569 · Cited by 281 · see citing works
Mizuno, T., Murakami, H., Fujii, M., Ishiguro, F., Tanaka, I., Kondo, Y., Akatsuka, S., Toyokuni, S., Yokoi, K., Osada, H., et al. (2012) · Oncogene · doi:10.1038/onc.2012.5 · Cited by 279 · see citing works
LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260 · see citing works
Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436311 · Cited by 249 · see citing works
Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research · doi:10.1101/gr.104471.109 · Cited by 248 · see citing works
Zhang, J., Smolen, G. A., & Haber, D. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6205 · Cited by 243 · see citing works
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Xu, M. Z., Chan, S. W., Liu, A., Wong, K. F., Fan, S., Chen, J., Poon, R. T. P., Zender, L., Lowe, S. W., Hong, W., et al. (2010) · Oncogene · doi:10.1038/onc.2010.504 · Cited by 228 · see citing works
Morikawa, Y., Zhang, M., Heallen, T. R., Leach, J. P., Tao, G., Xiao, Y., Bai, Y., Li, W., Willerson, J. T., & Martin, J. F. (2015) · Science Signaling · doi:10.1126/scisignal.2005781 · Cited by 221 · see citing works
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216 · see citing works
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
Cebola, I., Rodríguez-Seguí, S., Cho, C. H., Bessa, J., Rovira, M., Luengo, M., Chhatriwala, M., Berry, A. A., Ponsa-Cobas, J., Maestro, M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3160 · Cited by 212 · see citing works
Methods and Statistics for Combining Motif Match Scores
Bailey, T. L., & Gribskov, M. (1998) · Journal of Computational Biology · doi:10.1089/cmb.1998.5.211 · Cited by 202 · see citing works
KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases
Xiao, L., Chen, Y., Ji, M., & Dong, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173468 · Cited by 190 · see citing works
Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.029 · Cited by 178 · see citing works
YAP/TEAD–Mediated Transcription Controls Cellular Senescence
Xie, Q., Chen, J., Han, F., Peng, S., Adams, U., Bai, Y., Huang, L., Li, J., Huang, J., Meng, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3793 · Cited by 172 · see citing works
Structural and functional analysis of the YAP-binding domain of human TEAD2
Tian, W., Yu, J., Tomchick, D. R., Pan, D., & Luo, X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000293107 · Cited by 171 · see citing works
Xia, Y., Chang, T., Wang, Y., Liu, Y., Li, W., Li, M., & Fan, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091770 · Cited by 167 · see citing works
Enhancers: Mechanisms of Action and Cell Specificity
Atchison, M. L. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.001015 · Cited by 157 · see citing works
Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq
Bottomly, D., Kyler, S. L., McWeeney, S. K., & Yochum, G. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq363 · Cited by 155 · see citing works
Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
Oh, H., Slattery, M., Ma, L., Crofts, A., White, K. P., Mann, R. S., & Irvine, K. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.008 · Cited by 145 · see citing works
Transcriptional enhancers in development and disease
Sakabe, N. J., Savic, D., & Nóbrega, M. A. (2012) · Genome biology · doi:10.1186/gb-2012-13-1-238 · Cited by 138 · see citing works
Jacquemin, P., Hwang, J.-J., MARTIAL, J. A., Dollé, P., & Davidson, I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21775 · Cited by 134 · see citing works
Anbanandam, A., Albarado, D. C., Nguyen, C. T. Y., Halder, G. A., Gao, X., & Veeraraghavan, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607171103 · Cited by 131 · see citing works
Integrating developmental signals: a Hippo in the (path)way
Mauviel, A., Nallet-Staub, F., & Varelas, X. (2011) · Oncogene · doi:10.1038/onc.2011.363 · Cited by 129 · see citing works
Liu, J.-Y., Li, Y.-H., Lin, H., Liao, Y.-J., Mai, S., Liu, Z.-W., Zhang, Z.-L., Jiang, L.-J., Zhang, J., Kung, H., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-349 · Cited by 117 · see citing works
A computational pipeline for comparative ChIP-seq analyses
Bardet, A. F., He, Q., Zeitlinger, J., & Stark, A. (2011) · Nature Protocols · doi:10.1038/nprot.2011.420 · Cited by 115 · see citing works
Self-citationThe mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 108 · see citing works
The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity
Michaloglou, C., Lehmann, W., Martin, T., Delaunay, C., Hueber, A., Barys, L., Niu, H., Billy, É., Wartmann, M., Ito, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061916 · Cited by 90 · see citing works
Self-citationHalder, G. A., & Carroll, S. B. (2001) · Development · doi:10.1242/dev.128.17.3295 · Cited by 85 · see citing works
Clinical and prognostic significance of Yes-associated protein in colorectal cancer
Wang, Y., Xie, C., Li, Q., Xu, K., & Wang, E. (2013) · Tumor Biology · doi:10.1007/s13277-013-0751-x · Cited by 79 · see citing works
Qing, Y., Yin, F., Wang, W., Zheng, Y., Guo, P., Schozer, F., Deng, H., & Pan, D. (2014) · eLife · doi:10.7554/elife.02564 · Cited by 72 · see citing works
YAP1acts as oncogenic target of 11q22 amplification in multiple cancer subtypes
Lorenzetto, E., Brenca, M., Boeri, M., Verri, C., Piccinin, E., Gasparini, P., Facchinetti, F., Rossi, S., Salvatore, G., Massimino, M., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1844 · Cited by 72 · see citing works
Song, M., Cheong, J., Kim, H., Noh, S. H., & Kim, H. (2012) · PubMed · Cited by 68 · see citing works
Hu, X., Xin, Y., Xiao, Y., & Zhao, J. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9757-y · Cited by 66 · see citing works
Mahajan, M., & Samuels, H. H. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06002 · Cited by 63 · see citing works
Transcription factor binding variation in the evolution of gene regulation
Dowell, R. D. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.08.005 · Cited by 61 · see citing works
Sikora-Wohlfeld, W., Ackermann, M., Christodoulou, E. G., Singaravelu, K., & Beyer, A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003342 · Cited by 60 · see citing works
Identification of transcription factor binding sites from ChIP-seq data at high resolution
Bardet, A. F., Steinmann, J., Bafna, S., Knoblich, J. A., Zeitlinger, J., & Stark, A. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt470 · Cited by 59 · see citing works
Self-citationSchwarzer, W., & Spitz, F. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.014 · Cited by 49 · see citing works
Jiang, S., Desai, D. S., Khan, S. R., & Eberhardt, N. L. (2000) · DNA and Cell Biology · doi:10.1089/10445490050128430 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206 · see citing works
YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works
Mechanisms of Hippo pathway regulation
Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667 · see citing works
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086 · see citing works
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
Moya, I. M., & Halder, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0086-y · Cited by 981 · see citing works
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
Kim, J., Piao, H.-L., Kim, B., Yao, F., Han, Z., Wang, Y., Xiao, Z., Siverly, A. N., Lawhon, S. E., Ton, B. N., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0252-3 · Cited by 772 · see citing works
Self-organization and symmetry breaking in intestinal organoid development
Serra, D., Mayr, U., Boni, A., Lukonin, I., Rempfler, M., Challet Meylan, L., Stadler, M. B., Strnad, P., Papasaikas, P., Vischi, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1146-y · Cited by 561 · see citing works
Self-citationComprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.001 · Cited by 500 · see citing works
The Hippo Signaling Network and Its Biological Functions
Misra, J. R., & Irvine, K. D. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031621 · Cited by 496 · see citing works
YAP/TAZ Signaling and Resistance to Cancer Therapy
Nguyen, C. D. K., & Yi, C. (2019) · Trends in Cancer · doi:10.1016/j.trecan.2019.02.010 · Cited by 437 · see citing works
The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
Yang, W., Ding, C. C., Sun, T., Rupprecht, G., Lin, C., Hsu, D. S., & Chi, J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.107 · Cited by 457 · see citing works
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction
Dupont, S. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.034 · Cited by 449 · see citing works
YAP and TAZ: a signalling hub of the tumour microenvironment
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0168-y · Cited by 379 · see citing works
YAP/TAZ functions and their regulation at a glance
Pocaterra, A., Romani, P., & Dupont, S. (2020) · Journal of Cell Science · doi:10.1242/jcs.230425 · Cited by 369 · see citing works
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
Sladitschek, H. L., Guarnieri, A., Brumana, G., Zanconato, F., Battilana, G., Xiccato, R. L., Panciera, T., Forcato, M., Bicciato, S., Guzzardo, V., et al. (2022) · Nature · doi:10.1038/s41586-022-04924-6 · Cited by 346 · see citing works
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
Chen, P., Zhao, D., Li, J., Liang, X., Li, J., Chang, A. H., Henry, V. K., Lan, Z., Spring, D. J., Rao, G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.003 · Cited by 338 · see citing works
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
Tanasa, M. P., Renna, M., Park, S. J., Menzies, F. M., Ricketts, T., Füllgrabe, J., Ashkenazi, A., Frake, R. A., Carnicer‐Lombarte, A., Bento, C. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05388-x · Cited by 318 · see citing works
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4
Zanconato, F., Battilana, G., Forcato, M., Filippi, L., Azzolin, L., Manfrin, A., Quaranta, E. G., Biagio, D. D., Sigismondo, G., Guzzardo, V., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0158-8 · Cited by 309 · see citing works
Yang, W., Huang, Z., Wu, J., Ding, C. C., Murphy, S. K., & Chi, J. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0691 · Cited by 302 · see citing works
Xu, M., Zhang, D., Luo, R., Wu, Y., Zhou, H., Kong, L., Bi, R., & Yao, Y. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.08.012 · Cited by 294 · see citing works
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
Totaro, A., Castellan, M., Battilana, G., Zanconato, F., Azzolin, L., Giulitti, S., Cordenonsi, M., & Piccolo, S. (2017) · Nature Communications · doi:10.1038/ncomms15206 · Cited by 295 · see citing works
YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo
Monroe, T. O., Hill, M. C., Morikawa, Y., Leach, J. P., Heallen, T., Cao, S., Krijger, P. H. L., de Laat, W., Wehrens, X. H. T., Rodney, G. G., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.01.017 · Cited by 289 · see citing works
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
Tao, G., Kahr, P. C., Morikawa, Y., Zhang, M., Rahmani, M., Heallen, T. R., Li, L., Sun, Z. Q., Olson, E. N., Amendt, B. A., et al. (2016) · Nature · doi:10.1038/nature17959 · Cited by 283 · see citing works
Pepe-Mooney, B. J., Dill, M. T., Alemany, A., Ordovas-Montanes, J., Matsushita, Y., Rao, A., Sen, A., Miyazaki, M., Anakk, S., Dawson, P. A., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.004 · Cited by 266 · see citing works
Fluid shear stress activates YAP1 to promote cancer cell motility
Lee, H. J., Diaz, M. F., Price, K. M., Ozuna, J. A., Zhang, S., Sevick-Muraca, E. M., Hagan, J. P., & Wenzel, P. L. (2017) · Nature Communications · doi:10.1038/ncomms14122 · Cited by 259 · see citing works
Regulation of TEAD Transcription Factors in Cancer Biology
Huh, H., Kim, D., Jeong, H.-S., & Park, H. (2019) · Cells · doi:10.3390/cells8060600 · Cited by 259 · see citing works
Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
Yu, M., Peng, Z., Qin, M., Liu, Y., Wang, J., Zhang, C., Lin, J., Dong, T., Wang, L., Li, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.010 · Cited by 250 · see citing works
Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Mamidi, A., Prawiro, C., Seymour, P. A., de Lichtenberg, K. H., Jackson, A. L., Serup, P., & Semb, H. (2018) · Nature · doi:10.1038/s41586-018-0762-2 · Cited by 230 · see citing works
A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy
Pobbati, A. V., & Hong, W. (2020) · Theranostics · doi:10.7150/thno.40889 · Cited by 223 · see citing works
Insights into recent findings and clinical application of YAP and TAZ in cancer
Franklin, J. M., Wu, Z., & Guan, K.-L. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00579-1 · Cited by 213 · see citing works
YAP/TAZ as therapeutic targets in cancer
Zanconato, F., Battilana, G., Cordenonsi, M., & Piccolo, S. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.05.002 · Cited by 216 · see citing works
Tang, Y., Feinberg, T. Y., Keller, E. T., Li, X.-Y., & Weiss, S. J. (2016) · Nature Cell Biology · doi:10.1038/ncb3394 · Cited by 212 · see citing works
Foster, C. T., Gualdrini, F., & Treisman, R. (2017) · Genes & Development · doi:10.1101/gad.304501.117 · Cited by 202 · see citing works
YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation
Hasegawa, K., Fujii, S., Matsumoto, S., Tajiri, Y., Kikuchi, A., & Kiyoshima, T. (2020) · The Journal of Pathology · doi:10.1002/path.5553 · Cited by 193 · see citing works
Pearson, J. D., Huang, K., Pacal, M., McCurdy, S. R., Lü, S., Aubry, A., Yu, T., Wadosky, K. M., Zhang, L., Wang, T., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.016 · Cited by 172 · see citing works
Chapeau, E. A., Sansregret, L., Galli, G. G., Chêne, P., Wartmann, M., Mourikis, T. P., Jaaks, P., Baltschukat, S., Barbosa, I. A. M., Bauer, D., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00754-9 · Cited by 163 · see citing works
Self-citationChen, Y.-A., Lu, C.-Y., Cheng, T., Pan, S., Chen, H., & Chang, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00060 · Cited by 155 · see citing works
YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
Szulzewsky, F., Holland, E. C., & Vasioukhin, V. I. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2020.12.018 · Cited by 154 · see citing works
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
Cogliati, B., Yashaswini, C. N., Wang, S., Sia, D., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00821-z · Cited by 157 · see citing works
Ma, S., Tang, T. T.-L., Probst, G. D., Konradi, A. W., Jin, C., Li, F., Gutkind, J. S., Fu, X., & Guan, K. (2022) · Nature Communications · doi:10.1038/s41467-022-28691-0 · Cited by 145 · see citing works
Moreno-Vicente, R., Pavón, D. M., Martín-Padura, I., Català-Montoro, M., Díez-Sánchez, A., Quílez-Álvarez, A., López, J. A., Sánchez‐Álvarez, M., Vázquez, J., Strippoli, R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.024 · Cited by 146 · see citing works
Pampari, A., Shcherbina, A., Kvon, E. Z., Kosicki, M., Nair, S., Kundu, S., Kathiria, A. S., Risca, V. I., Kuningas, K., Alasoo, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.25.630221 · Cited by 161 · see citing works
Vigneswaran, K., Boyd, N., Oh, S.-Y., Lallani, S. B., Boucher, A. B., Neill, S. G., Olson, J. J., & Read, R. D. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0018 · Cited by 132 · see citing works
NUAK2 is a critical YAP target in liver cancer
Yuan, W.-C., Pepe-Mooney, B. J., Galli, G. G., Dill, M. T., Huang, H., Hao, M., Wang, Y., Liang, H., Calogero, R., & Camargo, F. D. (2018) · Nature Communications · doi:10.1038/s41467-018-07394-5 · Cited by 127 · see citing works
Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
Chen, C., Hsu, S.-C., Chung, T.-Y., Chu, C.-Y., Wang, H.-J., Hsiao, P., Yeh, S.-D., Ann, D. K., Yen, Y., & Kung, H.-J. (2021) · Nature Communications · doi:10.1038/s41467-021-22652-9 · Cited by 119 · see citing works
Multidrug efflux transporter ABCG2: expression and regulation
Kukal, S., Guin, D., Rawat, C., Bora, S., Mishra, M., Sharma, P., Paul, P. R., Kanojia, N., Grewal, G. K., Kukreti, S., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03901-y · Cited by 119 · see citing works
YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer
Horie, M., Saito, A., Ohshima, M., Suzuki, H. I., & Nagase, T. (2016) · Cancer Science · doi:10.1111/cas.13078 · Cited by 117 · see citing works
The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
Lavado, A., Park, J. Y., Paré, J., Finkelstein, D., Pan, H., Xu, B., Fan, Y., Kumar, R. P., Neale, G. A. M., Kwak, Y. D., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.021 · Cited by 114 · see citing works
Tang, Y., & Weiss, S. J. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1280643 · Cited by 114 · see citing works
Najafova, Z., Tirado-Magallanes, R., Subramaniam, M., Hossan, T., Schmídt, G., Nagarajan, S., Baumgart, S. J., Mishra, V. K., Bedi, U., Hesse, E., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw826 · Cited by 114 · see citing works
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment
Xie, J., Si, X., Gu, S., Wang, M., Shen, J. H., Li, H., Shen, J. H., Li, D., Fang, Y., Liu, C., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01520 · Cited by 113 · see citing works
Wang, L., Zhang, Z., Yu, X., Huang, X., Liu, Z., Chai, Y., Yang, L., Wang, Q., Li, M., Zhao, J. H., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0476-9 · Cited by 110 · see citing works
Pajtler, K. W., Wei, Y., Okonechnikov, K., Silva, P. B. G., Vouri, M., Zhang, L., Brabetz, S., Sieber, L., Gulley, M., Mauermann, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11884-5 · Cited by 106 · see citing works
Walko, G., Woodhouse, S., Pisco, A. O., Rognoni, E., Liakath‐Ali, K., Lichtenberger, B. M., Mishra, A., Telerman, S. B., Viswanathan, P., Logtenberg, M. E. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms14744 · Cited by 105 · see citing works
Edwards, D. N., Ngwa, V. M., Wang, S., Shiuan, E., Brantley-Sieders, D. M., Kim, L. C., Reynolds, A. B., & Chen, J. (2017) · Science Signaling · doi:10.1126/scisignal.aan4667 · Cited by 44 · see citing works
Conserved NPPB + Border Zone Switches From MEF2- to AP-1–Driven Gene Program
van Duijvenboden, K., de Bakker, D. E. M., Man, J. C. K., Janssen, R., Günthel, M., Hill, M. C., Hooijkaas, I. B., van der Made, I., van der Kraak, P. H., Vink, A., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.038944 · Cited by 102 · see citing works
Chiara, G. D., Gervasoni, F., Fakiola, M., Godano, C., D’Oria, C., Azzolin, L., Bonnal, R. J. P., Moreni, G., Drufuca, L., Rossetti, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22544-y · Cited by 100 · see citing works
Ruivo, C. F., Bastos, N., Adem, B., Batista, I. A., Durães, C., Melo, C. A., Castaldo, S. A., Campos-Laborie, F. J., Moutinho-Ribeiro, P., Morão, B., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-324994 · Cited by 98 · see citing works
The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
Rognoni, E., & Walko, G. (2019) · Cells · doi:10.3390/cells8050411 · Cited by 100 · see citing works
Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies
Kim, M. H., & Kim, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2412-x · Cited by 98 · see citing works
A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations
Yamaguchi, H., & Taouk, G. M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00928 · Cited by 100 · see citing works
The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2
Yang, W., Lin, C., Wu, J., Chao, P.-Y., Chen, K., Chen, P., & Chi, J. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0534 · Cited by 99 · see citing works
A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma
Ilyas, S. I., Yamada, D., Hirsova, P., Bronk, S. F., Werneburg, N. W., Krishnan, A., Salim, W., Zhang, L. N., Trushina, E. V., Truty, M. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698472 · Cited by 94 · see citing works
Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma
Tomé-García, J., Erfani, P., Nudelman, G., Tsankov, A. M., Katsyv, I., Tejero, R., Zhang, B., Walsh, M. J., Friedel, R. H., Zaslavsky, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06258-2 · Cited by 93 · see citing works
Greuter, T., Yaqoob, U., Gan, C., Jalan-Sakrikar, N., Kostallari, E., Lu, J., Gao, J., Sun, L., Liu, M., Sehrawat, T. S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.029 · Cited by 92 · see citing works
Wu, B.-K., Mei, S.-C., Chen, E. H., Zheng, Y., & Pan, D. (2022) · Nature Genetics · doi:10.1038/s41588-022-01119-7 · Cited by 90 · see citing works
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism
Sun, L., Suo, C., Zhang, T., Shen, S., Gu, X., Qiu, S., Zhang, P., Wei, H., Ma, W., Yan, R., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01391-6 · Cited by 90 · see citing works
Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82 · see citing works
Ma, F., Tsou, P., Gharaee‐Kermani, M., Plazyo, O., Xing, X., Kirma, J., Wasikowski, R., Hile, G. A., Harms, P. W., Jiang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44645-6 · Cited by 84 · see citing works
Transcriptional integration of mitogenic and mechanical signals by Myc and YAPPreprint
Croci, O., Fazio, S., Biagioni, F., Donato, E., Cagánová, M., Curti, L., Doni, M., Sberna, S., Aldeghi, D., Biancotto, C., et al. (2017) · Genes & Development · doi:10.1101/gad.301184.117 · Cited by 86 · see citing works
Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
García-García, M., Sánchez-Perales, S., Jarabo, P., Calvo, E., Huyton, T., Fu, L., Ng, S. C., Sotodosos-Alonso, L., Vázquez, J., Casas‐Tintó, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28693-y · Cited by 87 · see citing works
TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
Elster, D., Tollot, M., Schlegelmilch, K., Ori, A., Rosenwald, A., Sahai, E. A., & von Eyß, B. (2018) · Nature Communications · doi:10.1038/s41467-018-05370-7 · Cited by 85 · see citing works
Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy
Juan, W. C., & Hong, W. (2016) · Genes · doi:10.3390/genes7090055 · Cited by 84 · see citing works
Deng, Y., Wu, L. M. N., Bai, S., Zhao, C., Wang, H., Wang, J., Xu, L., Sakabe, M., Zhou, W., Xin, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15161 · Cited by 86 · see citing works
The Hippo Pathway in Prostate Cancer
Salem, O., & Hansen, C. G. (2019) · Cells · doi:10.3390/cells8040370 · Cited by 85 · see citing works
Co-occurring Mutations of Tumor Suppressor Genes, LATS2 and NF2 , in Malignant Pleural Mesothelioma
Tranchant, R., Quetel, L., Tallet, A., Meiller, C., Renier, A., de Koning, L., de Reyniès, A., Pimpec‐Barthes, F. L., Zucman‐Rossi, J., Jaurand, M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1971 · Cited by 83 · see citing works
miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression
Chen, M., Wu, L., Tu, J., Zhao, Z., Fan, X., Mao, J., Weng, Q., Wu, X., Huang, L., Xu, M., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.010 · Cited by 83 · see citing works
Nie, M., Chen, N., Pang, H., Jiang, T., Jiang, W., Tian, P., Yao, L., Chen, Y., DeBerardinis, R. J., Li, W., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci160152 · Cited by 81 · see citing works
CellOracle: Dissecting cell identity via network inference and in silico gene perturbation
Kamimoto, K., Hoffmann, C. M., & Morris, S. A. (2020) · doi:10.1101/2020.02.17.947416 · Cited by 81 · see citing works
Szulzewsky, F., Arora, S., Hoellerbauer, P., King, C., Nathan, E., Chan, M., Cimino, P. J., Ozawa, T., Kawauchi, D., Pajtler, K. W., et al. (2020) · Genes & Development · doi:10.1101/gad.338681.120 · Cited by 81 · see citing works
Tsuji, T., Ozasa, H., Aoki, W., Aburaya, S., Funazo, T. Y., Furugaki, K., Yoshimura, Y., Yamazoe, M., Ajimizu, H., Yasuda, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13771-5 · Cited by 78 · see citing works
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
Anerillas, C., Mazan-Mamczarz, K., Herman, A. B., Munk, R., Lam, K.-W. G., Calvo-Rubio, M., Garrido, A., Tsitsipatis, D., Martindale, J. L., Altés, G., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00480-4 · Cited by 76 · see citing works
The Hippo Pathway as a Driver of Select Human Cancers
Kulkarni, A., Chang, M. T., Vissers, J. H. A., Dey, A., & Harvey, K. F. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.04.004 · Cited by 77 · see citing works
YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators
Hoxha, S., Shepard, A., Troutman, S. A., Diao, H., Doherty, J. R., Janiszewska, M., Witwicki, R. M., Pipkin, M. E., Ja, W. W., Kareta, M. S., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2415 · Cited by 76 · see citing works
Mechanical cue‐induced YAP instructs Skp2‐dependent cell cycle exit and oncogenic signaling
Jang, W., Kim, T., Koo, J. S., Kim, S. K., & Lim, D. (2017) · The EMBO Journal · doi:10.15252/embj.201696089 · Cited by 76 · see citing works
YAP‐TEAD signaling promotes basal cell carcinoma development via a c‐JUN/AP1 axis
Maglic, D., Schlegelmilch, K., Dost, A. F. M., Panero, R., Dill, M. T., Calogero, R., & Camargo, F. D. (2018) · The EMBO Journal · doi:10.15252/embj.201798642 · Cited by 76 · see citing works
The Hippo pathway modulates resistance to BET proteins inhibitors in lung cancer cells
Gobbi, G., Donati, B., Do Valle, I. F., Reggiani, F., Torricelli, F., Remondini, D., Castellani, G., Ambrosetti, D. C., Ciarrocchi, A., & Sancisi, V. (2019) · Oncogene · doi:10.1038/s41388-019-0924-1 · Cited by 69 · see citing works
Dedifferentiation and neuronal repression define familial Alzheimer’s disease
Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. (2020) · Science Advances · doi:10.1126/sciadv.aba5933 · Cited by 69 · see citing works
Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury
DiGiovanni, G. T., Han, W., Sherrill, T. P., Taylor, C. J., Nichols, D. S., Geis, N. M., Singha, U. K., Calvi, C. L., McCall, A. S., Dixon, M. M., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.173374 · Cited by 69 · see citing works
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor
Mori, S., Takeuchi, T., Ishii, Y., Yugawa, T., Kiyono, T., Nishina, H., & Kukimoto, I. (2017) · Journal of Virology · doi:10.1128/jvi.02413-16 · Cited by 69 · see citing works
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., et al. (2022) · eLife · doi:10.7554/elife.78810 · Cited by 68 · see citing works
Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells
Meli, V. S., Veerasubramanian, P. K., Downing, T. L., Wang, W., & Liu, W. F. (2023) · Science Signaling · doi:10.1126/scisignal.adc9656 · Cited by 72 · see citing works
The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
Pattschull, G., Walz, S., Gründl, M., Schwab, M., Rühl, E., Baluapuri, A., Vranesic, A. C., Kneitz, S., Wolf, E., Ade, C. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.071 · Cited by 66 · see citing works
Zhou, Y., Shan, T., Ding, W., Hua, Z., Shen, Y., Lu, Z., Chen, B., & Dai, T. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26357 · Cited by 65 · see citing works
Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond
Chakraborty, S., & Hong, W. (2018) · Cancers · doi:10.3390/cancers10020045 · Cited by 65 · see citing works
Sun, X., Ren, Z., Cun, Y., Zhao, C., Huang, X., Zhou, J., Hu, R., Su, X., Ji, L., Li, P., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa482 · Cited by 62 · see citing works
Targeting the Hippo pathway in cancer
Harvey, K. F., & Tang, T. T.-L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01234-0 · Cited by 64 · see citing works
A Novel Notch–YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma
Slemmons, K. K., Crose, L. E. S., Riedel, S., Sushnitha, M., Belyea, B., & Linardic, C. M. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0004 · Cited by 62 · see citing works
- Authors
- Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., & Bauer, A.
- Affiliations
- Novartis (Switzerland) (CH)
- Friedrich Miescher Institute (CH)
- University of Basel (CH)
- Corresponding author
- Schübeler, Dirk
- Bauer, Andreas
- ORCID
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-08-21
- Volume
- 11
- Issue
- 8
- Pages
- e1005465
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC4546604
- OpenAlex
- W1539804860
- Cited by
- 414
- References
- 98
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 53 · 2023: 52 · 2022: 42 · 2021: 52 · 2020: 42 · 2019: 38 · 2018: 33 · 2017: 29 · 2016: 17 · 2015: 2
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- European Commission (282510, 257082)
- SystemsX.ch
- FP7 Health (HEALTH-2010-257082, 282510)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- YAP, TEAD transcription factors, Hippo signaling pathway, enhancer activation, distal enhancers, H3K27 acetylation, chromatin binding, transcriptional regulation, oncogenes, cancer
- MeSH terms
- YAP-Signaling Proteins, TEA Domain Transcription Factors, Acetylation, Base Sequence, Binding Sites, DNA-Binding Proteins, Enhancer Elements, Genetic, Histones, Humans, Nuclear Proteins, Phosphoproteins, Protein Binding, Protein Processing, Post-Translational, Transcription Factors, Transcriptional Activation, Consensus Sequence, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
