Saito, Takashi

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition

Latif-Hernandez, A., Shah, D., Craessaerts, K., Saido, T., Saito, T., De Strooper, B., Van der Linden, A., & D’Hooge, R. (2019) · Behavioural Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 92

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2018) · BMC Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 90

Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease

Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J., & Sargeant, T. J. (2018) · Behavioural Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 88

Istradefylline reduces memory deficits in aging mice with amyloid pathology

Orr, A. G., Lo, I., Schumacher, H., Ho, K., Gill, M., Guo, W., Kim, D. H., Knox, A., Saito, T., Saido, T. C., et al. (2018) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice

Kundu, P., Torres, E. R. S., Stagaman, K., Kasschau, K., Okhovat, M., Holden, S., Ward, S., Nevonen, K. A., Davis, B. A., Saito, T., et al. (2021) · Scientific Reports

Gut microbiota and healthAlzheimer's disease research and treatments

Cited by 75

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2019) · BMC Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 65

PLD3 gene and processing of APP

Fazzari, P., Horre, K., Arranz, A. M., Frigerio, C. S., Saito, T., Saido, T. C., & De Strooper, B. (2017) · Nature

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 54

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and social and anxiety-related behaviours

Pervolaraki, E., Hall, S. P., Foresteire, D., Saito, T., Saido, T. C., Whittington, M. A., Lever, C., & Dachtler, J. (2018) · Disease Models & Mechanisms

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 43

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Iguchi, A., Takatori, S., Kimura, S., Muneto, H., Wang, K., Etani, H., Ito, G., Sato, H., Hori, Y., Sasaki, J., et al. (2023) · iScience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 37

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice

Sos, K. E., Mayer, M. I., Takács, V. T., Major, A., Bardóczi, Z., Beres, B. M., Szeles, T., Saito, T., Saido, T. C., Mody, I., et al. (2020) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 37

Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

Miller, S. R., Luxem, K., Lauderdale, K., Nambiar, P., Honma, P. S., Ly, K. K., Bangera, S., Bullock, M., Shin, J., Kaliss, N., et al. (2024) · Cell Reports

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 24

Age-Dependent Behavioral and Metabolic Assessment of AppNL−G−F/NL−G−F Knock-in (KI) Mice

Wang, S., Ichinomiya, T., Savchenko, P., Devulapalli, S., Wang, D., Beltz, G., Saito, T., Saido, T. C., Wagner, S. L., Patel, H. H., et al. (2022) · Frontiers in Molecular Neuroscience

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 23

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Mumford, P., Tosh, J., Anderle, S., Gkanatsiou Wikberg, E., Lau, G., Noy, S., Cleverley, K., Saito, T., Saido, T. C., Yu, E., et al. (2022) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 22

Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer’s disease

Kobayashi, Y., Kohbuchi, S., Koganezawa, N., Sekino, Y., Shirao, T., Saido, T. C., Saito, T., & Saito, Y. (2022) · Biochemical and Biophysical Research Communications

Genetic and Kidney Cyst DiseasesAlzheimer's disease research and treatments

Cited by 18

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease

Islam, A., Saito, T., Saido, T., & Ali, A. B. (2023) · Seminars in Cell & Developmental Biology

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 17

β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Libera, J., Wang, Z., Kilci, A., Jenkins, M., Ortiz, A. R., et al. (2024) · Frontiers in Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 15