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Methylxanthines and Neurodegenerative Diseases: An Update

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The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

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Pharmacological Management of Apathy in Dementia

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Association Between Adenosine A2A Receptors and Connexin 43 Regulates Hemichannels Activity and ATP Release in Astrocytes Exposed to Amyloid-β Peptides

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A2A Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer’s Disease

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Can adenosine A2A receptor antagonists be used to treat cognitive impairment, depression or excessive sleepiness in Parkinson's disease?

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Hippocampal astrocytes induce sex-dimorphic effects on memory

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Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease

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Upregulation of Cortical A 2A Adenosine Receptors Is Reflected in Platelets of Patients with Alzheimer’s Disease

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Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice

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Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

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Blockade of adenosine A2A receptor alleviates cognitive dysfunction after chronic exposure to intermittent hypoxia in mice

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The role of adenosine A2A receptors in Alzheimer's disease and tauopathies

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Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer’s Disease

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The role of non-neuronal cells in hypogonadotropic hypogonadism

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Alternative Targets to Fight Alzheimer’s Disease: Focus on Astrocytes

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Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

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Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

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Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer’s Disease

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An Open Question: Is the A2A Adenosine Receptor a Novel Target for Alzheimer’s Disease Treatment?

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The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines

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Astrocytes Lingering at a Crossroads: Neuroprotection and Neurodegeneration in Neurocognitive Dysfunction

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Design, Synthesis, and Biological Activity Studies of Istradefylline Derivatives Based on Adenine as A2A Receptor Antagonists

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Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer’s Disease

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Astrocytic A2A receptors silencing negatively impacts hippocampal synaptic plasticity and memory of adult mice

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Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors

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Adenosine Signaling and Clathrin-Mediated Endocytosis of Glutamate AMPA Receptors in Delayed Hypoxic Injury in Rat Hippocampus: Role of Casein Kinase 2

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Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ1–42 to Model Early Alzheimer’s Disease

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Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson’s Disease

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Phenotypic Differences between the Alzheimer’s Disease-Related hAPP-J20 Model and HeterozygousZbtb20Knock-Out Mice

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Upregulation of adenosine A2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits

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Role of Adenosine A 2A Receptors in the Central Fatigue of Neurodegenerative Diseases

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The Anti-Parkinsonian A2A Receptor Antagonist Istradefylline (KW-6002) Attenuates Behavioral Abnormalities, Neuroinflammation, and Neurodegeneration in Cerebral Ischemia: An Adenosinergic Signaling Link Between Stroke and Parkinson’s Disease

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Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity

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Effects of adenosine A2A receptors on cognitive function in health and disease

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Adenosine Receptors in Alzheimer’s Disease

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Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders

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Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A2A Receptor-Mediated Effects in the Central Nervous System

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A2A Adenosine Receptor: Structures, Modeling, and Medicinal Chemistry

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Rbm8a regulates neurogenesis and reduces Alzheimer’s disease-associated pathology in the dentate gyrus of 5×FAD mice

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Chemobrain: An accelerated aging process linking adenosine A2A receptor signaling in cancer survivors

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The Neuroprotective Role of A2A Adenosine Purinoceptor Modulation as a Strategy Against Glioblastoma

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Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy

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Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy

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Adenosine Receptors and Neuroinflammation

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Purinergic modulation in Parkinson’s disease: the dual role of istradefylline in motor and cognitive outcomes

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The Adenosine Receptor: A Homeostatic Neuromodulator for Fine-Tuning Control of Cognition

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GPCRs with genetic associations to Alzheimer’s disease traits: an underdeveloped target class for disease progression

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Chronic intermittent hypoxia impairs glymphatic function in male mice through equilibrative nucleoside transporter–dependent adenosine dysregulation

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G protein-coupled receptors in neurodegenerative diseases

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Entwicklung und Charakterisierung von neuen Liganden des nukleären Rezeptors TLX

Faudone, G. (2022) · doi:10.21248/gups.68817

Roles of Purinergic Receptors in Alzheimer’s Disease

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Applications of App and MAPT knock-in mice to understanding disease mechanisms

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Therapeutic targeting of neuroinflammation in sphingolipidosis

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Neurophysiological In Vitro Model of Amyloid-β-Induced Deficits of Hippocampal LTP Involving Neuronal Adenosine A2A Receptor Dysfunction Through CD73

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Unraveling the anti-neuroinflammatory mechanisms of Cervus cucumis polypeptide injection in Alzheimer’s disease: insights from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation

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Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction

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The emerging role of astrocytes in spatial cognition, action and Alzheimer’s disease

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Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer’s Disease

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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

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